Navigation Links
Argonne scientists develop techniques for creating molecular movies
Date:4/15/2008

ARGONNE, Ill. (April 15, 2008) They may never win an Oscar, but scientists at the U.S. Department of Energys (DOE) Argonne National Laboratory have developed techniques for creating accurate movies of biological and chemical molecules, a feat only theorized up until now.

Biological and organic molecules in solution are far more complex than the standard crystalline structures of salt or metals since they are constantly moving and changing over time. These motions have not yet been seen directly, but scientists using the high intensity x-rays at the Advanced Photon Source have measured images that are blurred by these motions and have used them to create more accurate movies of molecular motions.

Computer simulations are currently the only way to visualize molecular motions in solution, but researchers have not had a means to check the accuracy of these simulations for complex molecules. For the first time, scientists can see the movements first hand and compare them to their theoretical counterparts.

The blurring that we see in our solution x-ray patterns are remarkably sensitive to the type of the molecular motion, senior chemist David Tiede said. For the first time, we are able to test the accuracy of the simulation and change it to fit data better. Without it, we had no way of knowing how accurate the models were.

Tiede hopes an improved accuracy in molecular modeling will give insights into the structure and behavior of the molecules. Collaborators at the National Institutes of Health have used this approach to help determine structures of important biological molecules.

Tiede and his collaborators also plan to examine how a structure reacts to an outside stimulus. By using a laser to excite the atoms, he will create a movie that shows how the molecule reacts to the initial laser pulse and also how it returns to a stable condition.

We hope to establish between good and bad molecular actors in important chemical processes like photosynthesis, solar energy and catalysts, Tiede said. Once we see that, we can make these processes work better.


'/>"/>

Contact: Brock Cooper
bcooper@anl.gov
630-252-5565
DOE/Argonne National Laboratory
Source:Eurekalert

Related biology news :

1. Bioinformatics technology developed at Argonne provides new insight into microbial activities
2. Research at Argonnes Advanced Photon Source reveals structure and behavior of collagen
3. New Argonne study may shed light on protein-drug interactions
4. Argonne National Lab acquires first SiCortex SC5832
5. Argonne helps China create cleaner Beijing for 2008 Olympics
6. Scientists debate the accuracy of Al Gores documentary An Inconvenient Truth
7. Scientists compiled 20th century temperature data in Spain as evidence of climatic change
8. Atmospheric scientists gear up for collaborative airborne campaigns
9. AMNH scientists grace Science & Nature covers
10. Scientists uncover the potential to control adult stem cells
11. Scientists ask whether microscaffolding can help stem cells rebuild brain after stroke damage
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/6/2017)... Forecasts by Product Type (EAC), ... End-Use (Transportation & Logistics, Government & Public Sector, Utilities ... Generation Facility, Nuclear Power), Industrial, Retail, Business Organisation (BFSI), ... you looking for a definitive report on the $27.9bn ... ...
(Date:4/4/2017)... 4, 2017   EyeLock LLC , a leader ... United States Patent and Trademark Office (USPTO) has issued ... linking of an iris image with a face image ... the company,s 45 th issued patent. ... timely given the multi-modal biometric capabilities that have recently ...
(Date:3/30/2017)... YORK , March 30, 2017 Trends, ... type (physiological and behavioral), by technology (fingerprint, AFIS, iris ... voice recognition, and others), by end use industry (government ... and immigration, financial and banking, and others), and by ... Europe , Asia Pacific , ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... YORBA LINDA, CA (PRWEB) , ... October 11, ... ... adapted to upregulate any gene in its endogenous context, enabling overexpression experiments and ... activation (CRISPRa) system with small RNA guides is transformative for performing systematic gain-of-function ...
(Date:10/11/2017)... , Oct. 11, 2017  VMS BioMarketing, a leading ... a nationwide oncology Clinical Nurse Educator (CNE) network, which will ... need for communication among health care professionals to enhance the ... nurses, office staff, and other health care professionals to help ... breast cancer. ...
(Date:10/11/2017)... ... October 11, 2017 , ... Singh Biotechnology today announced that ... SBT-100, its novel anti-STAT3 (Signal Transducer and Activator of Transcription 3) B VHH13 ... cross the cell membrane and bind intracellular STAT3 and inhibit its function. Dysregulation ...
(Date:10/10/2017)... ... October 10, 2017 , ... Dr. Bob Harman, founder and ... San Diego Rotary Club. The event entitled “Stem Cells and Their ... 300+ attendees. Dr. Harman, DVM, MPVM was joined by two human doctors: Peter ...
Breaking Biology Technology: