Navigation Links
Are we closer to understanding the cause of deadly sepsis?
Date:11/16/2012

New Rochelle, NY, November 13, 2012Following an infection, dysregulation of the immune system can result in a systemic inflammatory response and an often fatal condition called severe sepsis or septic shock. Sepsis is not uncommon, yet its cause and underlying immune dysfunction remain poorly understood. Regulatory T cells (Tregs), a component of the immune system, now appear to have an important role in suppressing the immune response in advance of sepsis, and understanding this role may lead to new therapeutic strategies for improving patient outcomes, as described in a review article in Journal of Interferon & Cytokine Research, a peer-reviewed publication from Mary Ann Liebert, Inc., publishers. The article is available free online on the Journal of Interferon & Cytokine Research website.

Li-Na Jiang, Yong-Ming Yao, and Zhi-Yong Sheng, Chinese PLA General Hospital, Beijing, and Hebei North University, Zhyangjiakou, China, review the growing body of literature supporting a link between alterations in Treg function and the development of sepsis, based on animal studies and preliminary human studies. In the article "The Role of Regulatory T Cells in the Pathogenesis of Sepsis and Its Clinical Implications (http://online.liebertpub.com/doi/full/10.1089/jir.2011.0080)," the authors suggest that accumulating experimental and clinical evidence indicates that manipulating Tregs may offer a promising strategy for treating patients with septic shock.

"Regulatory T cells are receiving much attention as important determinants of both beneficial and detrimental immune responses," says Co-Editor-in-Chief Thomas A. Hamilton, PhD, Chairman, Department of Immunology, Cleveland Clinic Foundation. "This review brings focus to the function of this important cell population in the context of sepsis, a condition more frequently associated with innate immunity."


'/>"/>

Contact: Vicki Cohn
vcohn@liebertpub.com
914-740-2100
Mary Ann Liebert, Inc./Genetic Engineering News
Source:Eurekalert  

Related biology news :

1. Oil from algae closer to reality through studies by unique collaboration of scientists
2. Pilot Results Move GHX Closer to Delivery of Healthcare Industrys First Implantable Device Supply Chain Solution
3. Synthetic diamond steps closer to next generation of high performance electrochemical applications
4. U of Alberta researcher steps closer to understand autoimmune diseases
5. Scientists deepen genetic understanding of MS
6. Major advances in understanding the regulation and organization of the human genome
7. Study of fruit fly chromosomes improves understanding of evolution and fertility
8. Understanding the biological and ecological implications of safe nanotechnology
9. Joslin researchers gain new understanding of diabetes and kidney disease
10. Stem cell research aids understanding of cancer
11. Discovery increases understanding how bacteria spread: U of A study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Are we closer to understanding the cause of deadly sepsis?
(Date:4/3/2017)... April 3, 2017  Data captured by ... platform, detected a statistically significant association between ... to treatment and objective response of cancer ... to predict whether cancer patients will respond ... as well as to improve both pre-infusion potency ...
(Date:3/28/2017)... The report "Video Surveillance Market ... Storage Devices), Software (Video Analytics, VMS), and Service (VSaaS, ... to 2022", published by MarketsandMarkets, the market was valued ... to reach USD 75.64 Billion by 2022, at a ... year considered for the study is 2016 and the ...
(Date:3/23/2017)... , Mar. 23, 2017 Research and ... System Market Analysis & Trends - Industry Forecast to 2025" ... ... grow at a CAGR of around 8.8% over the next decade ... industry report analyzes the market estimates and forecasts for all the ...
Breaking Biology News(10 mins):
(Date:6/19/2017)... ... 19, 2017 , ... Tunnell Consulting has been solving the most ... biggest challenges faced by life sciences, biotech and pharmaceuticals companies today is in interpreting ... Abraham , who is well known in the industry and brings significant high-level expertise ...
(Date:6/16/2017)... Rocky Hill, CT (PRWEB) , ... June 16, 2017 , ... ... of last night’s Entrepreneur Innovation Awards (EIA), held at The LOFT at Chelsea Piers ... their innovative project ideas to a panel of judges for an opportunity to secure ...
(Date:6/15/2017)... ... June 15, 2017 , ... angelMD announced the closure ... Dan Parsley, angelMD’s SVP of Corporate Development, served as the syndicate leader for ... part of Saranas’ recently announced $4 million Series B financing round. , Saranas ...
(Date:6/14/2017)... Bangkok, Thailand (PRWEB) , ... June 14, 2017 ... ... Thailand Center of Excellence for Life Sciences (TCELS) announces that they’re co-hosting a ... 19-22, 2017. , BIO, the largest biotech industry gathering in the world, ...
Breaking Biology Technology: