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Are the monoamines involved in shaping conduct disorders?
Date:9/13/2009

MAO gene variants are highly dependent on psychosocial environment for behaviour.

  • Another clinically important result is the finding of dramatic sex differences with regard to the direction of behaviour related to the interaction between MAO gene variants and environment.

    Conclusion

    Apart from psychosocial influences, biological factors have a major influence on personality traits and behaviour.

    The aggregation of certain risk factors in the same individual has been shown to contribute to the development of antisocial behaviour. Research findings suggest that both the molecular and the psychosocial mechanisms underlying emotional response and antisocial behaviour may differ between males and females.

    Based on gene-environment interactions, the brain monoamine systems play a crucial role in shaping personality traits and conduct disorder. The MAO genes appear to be the first genes strongly linked with either antisocial behaviour or conduct disorder.

    Individuals with one set of MAO gene variants seem to be virtually independent of environment for the risk of e.g. antisocial behaviour, and in this way could explain resilience towards an unfavourable environment. In contrast, those with another set of MAO gene variants are highly dependent on psychosocial environment and have considerable vulnerability for antisocial behaviour.


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    • Contact: Sonja Mak
    s.mak@update.europe.at
    431-405-5734
    European College of Neuropsychopharmacology
    Source:Eurekalert

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