HOUSTON, April 15, 2008 -- An investigation of the genes that govern spore formation in the bacteria B. subtilis shows that chance plays a significant role in determining which of the microbes sacrifice themselves for the colony and which go on to form spores.
B. subtilis, a common soil bacteria, is a well-known survivor. When running short of food, it can alternatively band together in colonies or encase itself in a tough, protective spore to wait for better times. In fact, B. subtilis is so good at making spores that it's often used as a model organism by biologists who study bacterial spore formation.
"It's too early to say whether B. subtilis is truly altruistic," said co-author Oleg Igoshin, assistant professor of bioengineering at Rice University. "What is clear from this is that not all bacteria are going to look and act the same, and that's something that can be overlooked when people either study or attempt to control bacteria with population-wide approaches."
For example, Igoshin said doctors and food safety engineers might need to amend general approaches aimed at controlling bacteria with more targeted methods that also account for the uncharacteristic individual.
The new results appear in the April 15 issue of Molecular Systems Biology. The experimental work, which was done by Jan-Willem Veening, currently at Newcastle University, and by other members of Oscar Kuipers' research group at the University of Groningen in the Netherlands, focused on the B. subtilis genes that regulate both spore formation and the production cycles of two proteins -- subtilisin and bacillopeptidase. These two proteins help break apart dead cells and convert them into food. They are produced and released into the surrounding environment by B. subtilis cells that are running low on food.
From previous studies, scientists know there is some overlap between genes that control the production of the two proteins and those that contr
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