Navigation Links
Are cancers newly evolved species?
Date:7/26/2011

oes change as a cancer cell divides, because the chromosomes are disrupted and thus don't copy perfectly. But the karyotype is "only flexible within a certain margin," Duesberg said. "Within these margins it remains stable, despite its flexibility."

Karyographs display karyotype variability

Duesberg and his colleagues developed karyographs as a way to display the aneuploid nature of a cell's karyotype and its stability across numerous cell cultures. Using these karyographs, he and his colleagues analyzed several cancers, clearly demonstrating that the karyotype is amazingly similar in all cells of a specific cancer line, yet totally different from the karyotypes of other cancers and even the same type of cancer from a different patient.

HeLa cells are a perfect example. Perhaps the most famous cancer cell line in history, HeLa cells were obtained in 1951 from a cervical cancer that eventually killed a young black woman named Henrietta Lacks. The 60-year-old cell line derived from her cancer has a relatively stable karyotype that keeps it alive through division after division.

"Once a cell has crossed that barrier of autonomy, it's a new species," Duesberg said. "HeLa cells have evolved in the laboratory and are now even more stable than they probably were when they first arose."

The individualized karyotypes of cancers resemble the distinct karyotypes of different species,, Duesberg said. While biologists have not characterized the karyotypes of most species, no two species are known that have the same number and arrangement of chromosomes, including those of, for example, gorillas and humans, who share 99 percent of their genes.

Duesberg argues that his speciation theory explains cancer's autonomy, immortality and flexible, but relatively stable, karyotype. It also explains the long latency period between initial aneuploidization and full blown cancer, because there is such a low probability of evolving
'/>"/>

Contact: Robert Sanders
rsanders@berkeley.edu
510-643-6998
University of California - Berkeley
Source:Eurekalert

Page: 1 2 3 4 5

Related biology news :

1. 2 genetic variations predict second cancers after radiation for children with Hodgkin lymphoma
2. Novel pathway regulating angiogenesis may fight retinal disease, cancers
3. Sandia and UNM lead effort to destroy cancers
4. Study shows new treatment strategy effective for certain lung cancers
5. Blocking rogue gene could stop the spread of most cancers
6. An earlier start on diagnosing breast, prostate cancers
7. Researchers discover genetic predisposition for breast, kidney cancers
8. Combination therapy reduced HER2-positive breast cancers
9. Discovery of a mechanism that controls the expression of a protein involved in numerous cancers
10. Clue to unusual drug-resistant breast cancers found
11. Fighting cancers by tagging their triggers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/18/2014)... , Nov. 18, 2014  The Secure Identity ... Association today jointly announce the formation of The ... of its Identity and Biometric Entry and ... Framework received official support from BORDERPOL, the international ... improve and provide expertise regarding border security, traveler ...
(Date:11/18/2014)... BETHESDA, Md. , Nov. 17, 2014 The ... European and U.S. regulatory agencies will speak and at least ... Quality Metrics Conference at the Omni Shoreham Hotel in ... is pleased once again to have significant support from the ... and Europe in our effort to ...
(Date:11/15/2014)... , Nov. 13, 2014  While we may still be ... McCoy used in "Star Trek" to gain instant access to ... to work with smartphones and tablets for monitoring and measuring ... healthcare world. This may seem a tad Orwellian to some, ... adopt some of these technological opportunities into their healthcare regime. ...
Breaking Biology News(10 mins):Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 3FDA's Janet Woodcock, EMA's Emer Cooke Headline PDA Quality Metrics Conference 2Americans May Be Ready for a Brave New World of Healthcare 2Americans May Be Ready for a Brave New World of Healthcare 3Americans May Be Ready for a Brave New World of Healthcare 4
... available in French . , Dopamine replacement ... with Parkinson,s disease, can, at times, adversely affect cognition. ... Head of the Neurophysiological and Neuroimaging Research theme at ... de Montral (IUGM), which is affiliated with the Universit ...
... , Birds with high levels of stress hormones have ... to their brood, according to new biology research at ... stress hormone is often thought to indicate an individual ... mating success. However, our research indicates that tree swallows ...
... and new research by University of California, Berkeley, neuroscientists ... and other highly emotional experiences lead to incredibly strong ... 14) in advance of publication in the journal ... report a new way for emotions to affect memory: ...
Cached Biology News:Researchers identify why dopamine replacement therapy has a paradoxical effect on cognition 2Stress may lead to better bird parenting 2Fear boosts activation of young, immature brain cells 2Fear boosts activation of young, immature brain cells 3
(Date:12/17/2014)... Achim Noack has been named global ... In this position, Noack will assist Jerry Stoller, CEO ... marketing strategy and supervise global marketing management and implementation ... tremendous knowledge and experience in the crop protection industry,” ... and innovative thinking will be a great asset for ...
(Date:12/17/2014)... (PRWEB) December 17, 2014 Once more, ... provide a larger packaged waste water treatment plant to ... Abdullah Economic City (KAEC). Two years ago Bioshaft successfully ... Gate Development, serving two residential towers with an occupancy ... over a quarter million gallons per day and was ...
(Date:12/17/2014)... IN (PRWEB) December 17, 2014 ... Laboratory Excellence following its most recent COLA inspection. ... by COLA, a national healthcare accreditation organization. Accreditation ... standards of quality in day-to-day operations, demonstrate continued ... pass a rigorous on-site laboratory survey. ...
(Date:12/17/2014)... Diego, CA (PRWEB) December 17, 2014 ... and activation agency and member of the Huntsworth Health ... Gonzales to its executive team. In her role, Gonzales ... , “We are incredibly honored to welcome a ... Agency Chief and CEO, Gaëtan Fraikin. “She is a ...
Breaking Biology Technology:Achim Noack Joins Stoller Group as Global Vice President of Marketing and Administration 2Xeno Diagnostics Receives 3rd Award for Laboratory Excellence 2Audacity Welcomes Healthcare Communications Expert Jamie Gonzales as Senior Vice President of Client Services 2
... CARLSBAD, Calif., Jan. 6 AutoGenomics, a leader in ... company has been invited and has accepted to present ... January 12-15, 2009 at the Westin St. Francis Hotel ... President & CEO will provide an overview of the ...
... Jan. 6 /PRNewswire-FirstCall/ - SemBioSys Genetics Inc. (TSX:SBS), ... plants, today announced it has received US$2,500,000 from ... for the option agreement and issuance of 2,400,000 ... 2008. The transaction provides MannKind with the option ...
... ST. LOUIS, Mo., Jan. 6 Sigma-Aldrich,(Nasdaq: ... with the acquisition of,Seppro(R) affinity depletion technology and ... Inc. Seppro depletion products enable,scientists to measure ... range of mammalian and plant biological samples. ...
Cached Biology Technology:SemBioSys receives US$2.5 million from option agreement with MannKind for plant-produced insulin 2SemBioSys receives US$2.5 million from option agreement with MannKind for plant-produced insulin 3Sigma-Aldrich Acquires Seppro(R) Depletion Technology From GenWay Biotech 2Sigma-Aldrich Acquires Seppro(R) Depletion Technology From GenWay Biotech 3