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Arctic ground squirrels muscle up to hunker down
Date:9/15/2011

When Arctic ground squirrels are getting ready to hibernate they don't just get fat they pack on muscle at a rate that would make a bodybuilder jealous. And they do it without suffering the harmful effects that high levels of testosterone and other anabolic steroids usually cause. University of Toronto Scarborough (UTSC) researchers have started to untangle how the squirrels manage it, and their results could someday have implications for human health.

Arctic ground squirrels, it turns out, ramp up their anabolic steroid levels and keep them high not just during the spring mating season, but during the summer and fall. To avoid the damaging effects of these high levels, they seem to suppress androgen receptors in all tissues except muscle, according to Rudy Boonstra, professor of biological sciences at UTSC.

Boonstra's research will appear in an upcoming issue of Functional Ecology. It is co-authored by Brendan Delehanty, also of UTSC, and Adrian J. Bradley of the University of Queensland.

Like many other hibernators, Arctic ground squirrels go underground in winter and burn the fat they stored up during the summer and fall. But Arctic ground squirrels have a problem faced by almost no other hibernator. Other animals dig below the frost line and hibernate in a relatively warm 0 C. Because Arctic ground squirrels can't get below the permafrost, they have to spend their eight-month hibernation at temperatures as low as -23 C.

Thus to stay alive their metabolisms have to run at a higher rate than other hibernators. Stored fat provides much of the energy they need, but it can't give them the levels of glucose required by vital tissues such as the brain and heart. Only burning protein stored in muscles will provide the needed glucose.

To see what was going on, Boonstra and colleagues examined the blood of Arctic ground squirrels in Canada's northern Yukon territory over an entire active season, and compared it with blood
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Contact: Rudy Boonstra
boonstra@utsc.utoronto.ca
416-287-7419
University of Toronto Scarborough
Source:Eurekalert

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