Navigation Links
Arbor Vita and WRAIR sign CRADA for traumatic brain injury collaboration

Sunnyvale, CA September 8, 2008 The U.S. Department of Applied Neurobiology at the Walter Reed Army Institute of Research (WRAIR) and Arbor Vita Corporation (AVC) have signed a Cooperative Research and Development Agreement (CRADA) for research and development of treatments for traumatic brain injury (TBI). The alliance is based on discoveries made from a collaborative effort between AVC and NoNO Inc., of Toronto, Canada, and will explore the use of the companies' NA-1 compound as a novel neuroprotective agent for severe brain injury of soldiers and civilians injured in explosions such as roadside bombs. NA-1 is an investigational compound that targets a PDZ protein and is in clinical trials for the treatment of stroke.

Arbor Vita Corporation has a novel drug development strategy targeting the PDZ family of proteins critical elements that organize and regulate many signaling pathways in cells. The disruption of PDZ interactions provides a means to control specific signaling cascades in complex diseases, including that which controls the death of neurons in the brain following a stroke. The combined research approach of WRAIR brain trauma scientists and neuroprotection experts and the neuroscience research teams of AVC and NoNO Inc. will provide a unique opportunity for conducting advanced preclinical neuroprotection research in a model of brain injury that mimics some types of battlefield injuries. The ultimate goal of the program is the advanced development of a novel therapy for the acute treatment of brain injury.

Traumatic brain injuries from bombs and other explosions are troubling consequences of modern urban and terrorist warfare for both military personnel and civilians. Every year, approximately 1,400,000 individuals in the U.S. and upwards of 2,000,000 worldwide experience traumatic brain injuries. To date, despite very encouraging preclinical results, almost all Phase II/III neuroprotection clinical trials for stroke and TBI have failed to show any consistent improvement in outcome for TBI patients. Only therapies that ameliorate blood flow or target secondary effects are in clinical use. There is a clear unmet medical need for such a drug.

The CRADA between the WRAIR and Arbor Vita represents a collaborative effort employing state-of-the-art preclinical research platforms and drug development strategies that may yield a therapeutic agent ready for human clinical trial assessment. Under the terms of the CRADA, Arbor Vita will supply the clinical materials of NA-1 along with supporting preclinical and human clinical research data. WRAIR will conduct a dose-response study to establish proof of efficacy in a variety of brain injury models and, if successful, conduct additional studies in support of Phase II human clinical trials.


Contact: Debra Bannister
Arbor Vita Corporation

Related biology news :

1. Heavy metal link to mutations, low growth and fertility among crustaceans in Sydney Harbor tributary
2. Shipwrecks on coral reefs harbor unwanted species
3. Cold Spring Harbor Protocols highlights gene silencing, cancer cell biology methods
4. A field guide to the landscape of Cold Spring Harbor Laboratory
5. Watson-inspired innovation in research at Cold Spring Harbor Laboratory
6. Cold Spring Harbor Protocols features methods for analyzing genomes and plant cells
7. Cold Spring Harbor Protocols features classic approaches for analyzing chromosomes
8. Ugandan monkeys harbor evidence of infection with unknown poxvirus
9. Sydney harbors deadly diet for sea creatures
10. Cold Spring Harbor Laboratory scientists devise potential approach to treat spinal muscular atrophy
11. Cold Spring Harbor Protocols features methods to screen genomes and analyze evolution
Post Your Comments:
(Date:11/10/2015)... 10, 2015  In this report, the ... of product, type, application, disease indication, and ... report are consumables, services, software. The type ... biomarkers, efficacy biomarkers, and validation biomarkers. The ... diagnostics development, drug discovery and development, personalized ...
(Date:11/2/2015)... Calif. , Nov. 2, 2015  SRI International ... million to provide preclinical development services to the National ... contract, SRI will provide scientific expertise, modern testing and ... variety of preclinical pharmacology and toxicology studies to evaluate ... --> The PREVENT Cancer Drug Development Program ...
(Date:10/29/2015)... , Oct. 29, 2015  Connected health pioneer, ... driving the explosion of technology-enabled health and wellness, and ... new book, The Internet of Healthy Things ... sensors or smartphones even existed, Dr. Kvedar, vice president, ... of health care delivery, moving care from the hospital ...
Breaking Biology News(10 mins):
(Date:11/27/2015)... November 27, 2015 ... popularity of companion diagnostics is one of ... market with pharmaceutical companies and diagnostic manufacturers ... tests. . --> ... report on global cancer biomarkers market spread ...
(Date:11/25/2015)... , Nov. 25, 2015  PharmAthene, Inc. (NYSE MKT: ... adopted a stockholder rights plan (Rights Plan) in an ... loss carryforwards (NOLs) under Section 382 of the Internal ... --> PharmAthene,s use of its NOLs could be ... as defined in Section 382 of the Code. In ...
(Date:11/25/2015)... , Nov. 25, 2015  Neurocrine Biosciences, Inc. ... Gorman , President and CEO of Neurocrine Biosciences, will ... Conference in New York . ... visit the website approximately 5 minutes prior to the ... replay of the presentation will be available on the ...
(Date:11/25/2015)... PORTLAND, Oregon , November 25, 2015 /PRNewswire/ ... Deep Market Research Report is a professional and ... Genomics industry.      (Logo: ... basic overview of the industry including definitions, classifications, ... analysis is provided for the international markets including ...
Breaking Biology Technology: