Navigation Links
Arbor Vita and WRAIR sign CRADA for traumatic brain injury collaboration

Sunnyvale, CA September 8, 2008 The U.S. Department of Applied Neurobiology at the Walter Reed Army Institute of Research (WRAIR) and Arbor Vita Corporation (AVC) have signed a Cooperative Research and Development Agreement (CRADA) for research and development of treatments for traumatic brain injury (TBI). The alliance is based on discoveries made from a collaborative effort between AVC and NoNO Inc., of Toronto, Canada, and will explore the use of the companies' NA-1 compound as a novel neuroprotective agent for severe brain injury of soldiers and civilians injured in explosions such as roadside bombs. NA-1 is an investigational compound that targets a PDZ protein and is in clinical trials for the treatment of stroke.

Arbor Vita Corporation has a novel drug development strategy targeting the PDZ family of proteins critical elements that organize and regulate many signaling pathways in cells. The disruption of PDZ interactions provides a means to control specific signaling cascades in complex diseases, including that which controls the death of neurons in the brain following a stroke. The combined research approach of WRAIR brain trauma scientists and neuroprotection experts and the neuroscience research teams of AVC and NoNO Inc. will provide a unique opportunity for conducting advanced preclinical neuroprotection research in a model of brain injury that mimics some types of battlefield injuries. The ultimate goal of the program is the advanced development of a novel therapy for the acute treatment of brain injury.

Traumatic brain injuries from bombs and other explosions are troubling consequences of modern urban and terrorist warfare for both military personnel and civilians. Every year, approximately 1,400,000 individuals in the U.S. and upwards of 2,000,000 worldwide experience traumatic brain injuries. To date, despite very encouraging preclinical results, almost all Phase II/III neuroprotection clinical trials for stroke and TBI have failed to show any consistent improvement in outcome for TBI patients. Only therapies that ameliorate blood flow or target secondary effects are in clinical use. There is a clear unmet medical need for such a drug.

The CRADA between the WRAIR and Arbor Vita represents a collaborative effort employing state-of-the-art preclinical research platforms and drug development strategies that may yield a therapeutic agent ready for human clinical trial assessment. Under the terms of the CRADA, Arbor Vita will supply the clinical materials of NA-1 along with supporting preclinical and human clinical research data. WRAIR will conduct a dose-response study to establish proof of efficacy in a variety of brain injury models and, if successful, conduct additional studies in support of Phase II human clinical trials.


Contact: Debra Bannister
Arbor Vita Corporation

Related biology news :

1. Heavy metal link to mutations, low growth and fertility among crustaceans in Sydney Harbor tributary
2. Shipwrecks on coral reefs harbor unwanted species
3. Cold Spring Harbor Protocols highlights gene silencing, cancer cell biology methods
4. A field guide to the landscape of Cold Spring Harbor Laboratory
5. Watson-inspired innovation in research at Cold Spring Harbor Laboratory
6. Cold Spring Harbor Protocols features methods for analyzing genomes and plant cells
7. Cold Spring Harbor Protocols features classic approaches for analyzing chromosomes
8. Ugandan monkeys harbor evidence of infection with unknown poxvirus
9. Sydney harbors deadly diet for sea creatures
10. Cold Spring Harbor Laboratory scientists devise potential approach to treat spinal muscular atrophy
11. Cold Spring Harbor Protocols features methods to screen genomes and analyze evolution
Post Your Comments:
(Date:11/19/2015)... , Nov. 19, 2015  Although some 350 ... is dominated by a few companies, according to Kalorama ... own 51% of the market share of the 6.1 ... The World Market for Molecular Diagnostic s . ... "The market is still controlled by one company and ...
(Date:11/17/2015)... LIVERMORE, Calif. , Nov. 17, 2015  Vigilant ... has joined its Board of Directors. ... Vigilant,s Board after recently retiring from the partnership at ... owning 107 companies with over $140 Billion in revenue.  ... performance improvement across all the TPG companies, from 1997 ...
(Date:11/12/2015)... LONDON , Nov. 11, 2015   ... and reliable analytical tools has been paving the ... and qualitative determination of discrete analytes in clinical, ... sensors are being predominantly used in medical applications, ... and environmental sectors due to continuous emphasis on ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... KUALA LUMPUR, Malaysia , Nov. 24, 2015 ... the global contract research organisation (CRO) market. The ... to result in lower margins but higher volume ... With increased capacity and scale, however, margins in ... Contract Research Organisation (CRO) Market ( ...
(Date:11/24/2015)... ... November 24, 2015 , ... ... metabolism. But unless it is bound to proteins, copper is also toxic to ... researchers at Worcester Polytechnic Institute (WPI) will conduct a systematic study of copper ...
(Date:11/24/2015)... ... November 24, 2015 , ... This fall, global software solutions leader ... five states to develop and pitch their BIG ideas to improve health and wellness ... competing for votes to win the title of SAP's Teen Innovator, an all-expenses paid ...
(Date:11/24/2015)... , Nov. 24, 2015 /PRNewswire/ - Aeterna ... announced today that the remaining 11,000 post-share consolidation ... Purchase Warrants (the "Series B Warrants") subject to ... exercised on November 23, 2015, which will result ... After giving effect to the issuance of such ...
Breaking Biology Technology: