Navigation Links
Apolipoprotein(a): A natural regulator of inflammation
Date:12/24/2008

In a study to be published in the January 09 issue of Experimental Biology and Medicine, Hoover-Plow and co-workers in seeking to define a role of apo(a) in leukocyte recruitment have identified a novel activity of apo(a) apolipoprotein that may function as a natural and cell specific suppressor of the inflammatory response in vivo. In addition, a mechanism for this novel function of apo(a) was also identified: its selective regulation of cytokine production. These effects of apo(a) are independent of its molecular mimicry of Plg.

Lipoprotein(a) (Lp(a)) is similar to low density lipoprotein (LDL), but contains an additional apolipoprotein, apo(a). Numerous clinical studies conducted over the past 40 years have identified Lp(a) as a risk factor independent from LDL for a variety of cardiovascular pathologies. Much of the focus of apo(a) pathogenic activities has centered on its strong resemblance to plasminogen, the zymogen for plasmin, the primary enzyme for blood clot degradation. In addition to its important role in clot lysis, plasmin is required for leukocyte recruitment in inflammation. While several in vitro studies have demonstrated the interference of apo(a) in plasminogen leukocyte recruitment, evidence for this in vivo has been lacking.

In vivo investigation of Lp(a) function has been impeded by the lack of availability of small animal models. Lp(a) is expressed only in humans, nonhuman primates and the European hedgehog. In this study Hoover-Plow's group utilized mice with apo(a) in a plasminogen deficient or replete background to study leukocyte recruitment in three models of inflammation. Hoover-Plow said "In this study apo(a) impeded neutrophil recruitment in two of the models of inflammation, thioglycollate and lipopolysaccharide induced peritonitis. Apo(a) also inhibited neutrophil chemoattractants, and neutrophil recruitment was restored in mice administered neutrophil chemoattractants. The impaired neutrophil recruitment o
'/>"/>

Contact: Dr. Jane Hoover-Plow
hooverj@ccf.org
216-445-8207
Society for Experimental Biology and Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. New research shows how gene function drives natural selection in important class of genetic elements
2. Honey adds health benefits, is natural preservative and sweetener in salad dressings
3. Natural Capital Project to develop conservation software
4. Ecologists say metabolism accounts for why natural selection favors only some species
5. Natural and social sciences: ICSU embraces the need to work more closely together
6. International Council for Science launches major research program on natural disasters
7. Design of a compound that stabilizes the main natural suppressor of tumors
8. Discovery of natural compounds that could slow blood vessel growth
9. Natural childbirth linked to stronger baby bonding than C-sections
10. How plants fine tune their natural chemical defenses
11. Old before their time? Aging in flies under natural vs. laboratory conditions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... creating a new professorship in tissue engineering to ... Molecular Engineering and the Marine Biological Laboratory, supported ... and Eugene Bell Foundation., The Eugene Bell Professorship ... for Molecular Engineering. That endowed chair holder also ... Eugene Bell Center for Regenerative Biology and Tissue ...
(Date:7/11/2014)... Cell scientists have set a "mouse TRAP" to capture ... a recent study published in the Journal of ... a technique called TRAP to extract cellular and genetic ... by scientists at the Rockefeller Institute for Medical Research ... the protein-making machinery, or ribosomes, of the cell type ...
(Date:7/11/2014)... from The Chinese University of Hong Kong, BGI and ... linked to salt tolerance, with implication for improving this ... published online in Nature Communications provides an ... improvement. , Soybean is an important crop for the ... have less genetic diversities than their wild counterparts. Among ...
Breaking Biology News(10 mins):New professorship in tissue engineering links molecular engineering, marine biology 2BGI reports a novel gene for salt tolerance found in wild soybean 2
... our pleasure to welcome you to the SIBs 10th ... Switzerland. Amongst them, we are particularly happy to welcome ... will take place on Wednesday, 24th September at the ... heart of science Wednesday, 24 September ...
... know it,s good for you in other ways, but ... lung disease? It just might. According to recent ... lung concentrations of NRF2-dependent antioxidants, key components of the ... the severity of chronic obstructive pulmonary disease (COPD) in ...
... ships, that can sail throughout the body via the ... system and ferry their cargo of anti-cancer drugs and ... undetected. In a forthcoming issue of the Germany-based ... San Diego, UC Santa Barbara and MIT report that ...
Cached Biology News:COPD? Eat your veggies 2Researchers develop nano-sized 'cargo ships' to target and destroy tumors 2Researchers develop nano-sized 'cargo ships' to target and destroy tumors 3Researchers develop nano-sized 'cargo ships' to target and destroy tumors 4
(Date:7/11/2014)... , July 11, 2014 Research and ... Transfection Technology Market - Global Industry Analysis, Size, Share, ... their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... nucleic acids (either DNA or RNA) into cells. This ... of cancer cells and protein metabolism by affecting the ...
(Date:7/11/2014)... Cayenne Medical, Inc., a privately ... soft tissue reconstruction segment, announced the worldwide launch ... involving the shoulder and extremities. The SureLock System ... deployment method. The unique delivery eliminates manual tensioning ... or anchor displacement (also commonly know as anchor ...
(Date:7/10/2014)... (PRWEB) July 10, 2014 Terascala, the ... announced that Alan Swahn, a former vice president of ... team as vice president of marketing. Terascala’s software when ... and NetApp create the highest performance and most reliable ... appointed to guide Terascala’s channel expansion and broaden its ...
(Date:7/10/2014)... CA (PRWEB) July 10, 2014 Senior ... institutions and professional associations, addressed the challenges of “Reducing ... Medical Device Industries” through strategic sourcing. Describing the partnership ... with the Supply Chain Management Institute ( SCMI) ... event on June 24 at the Kroc Institute of ...
Breaking Biology Technology:International Transfection Technology Market - Industry Analysis, Size, Share, Growth, Trends and Forecast to 2019 2Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 2Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 3Terascala Expands Executive Team 2Terascala Expands Executive Team 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 2Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 4
... Its one thing for a dictator to control a ... its quite another for a totalitarian regime to block ... wireless laptop. , ,Perhaps that explains why some global ... Internet away from its American roots and substitute United ...
... Madison, Wis. Wisconsin businesses and individuals are ... New Products Awards Competition, which recognizes benefits coming ... emerging technologies. , ,Governor's New Products Awards ... (1,000 or more employees); large companies (500-999 employees); ...
... Madison Area Technical College's Network Security Specialist degree ... threats to computer systems and data, has earned federal certification ... Systems . , ,It is only one of two in ... MATC had to match its curriculum precisely to what the ...
Cached Biology Technology:Democracy and the Net - How American ideals are quietly influencing the world 2Democracy and the Net - How American ideals are quietly influencing the world 3
Mouse Amphiregulin MAb (Clone 206220)...
Anti-Digoxigenin-AP, Fab fragments; from sheep...
The antibody recognizes the peptide sequence ESESQGPK (aa 441-448) of human class III beta-tubulin specific for neurones....
Unique enzyme blend containing Taq and Pwo DNA Polymerase and another thermostable enzyme. The Expand 20 kbPLUS PCR System also includes an optimized reaction buffer, MgCl2 solution, and a human cont...
Biology Products: