Navigation Links
Apelin to rescue diabetics
Date:11/4/2008

Sugar is naturally present in the blood in the form of glucose and is stored in the liver or adipose tissue (fat) thanks to the action of insulin. Glucose is stored or directly used to ensure satisfactory function of the heart, brain and so on according to the body's demands.

In certain cases, this mechanism may deteriorate either because insulin is no longer produced (type 1 diabetes), or because the receptors located on the surface of liver cells are desensitized (type II diabetes). Consequently, the cell is no longer capable of assimilating glucose. Such a dysfunction causes a rise in blood sugar levels leading to the onset of numerous complications.

Philippe Valet's team has just found that our cells are equipped with a second pathway for the assimilation of glucose. This discovery is based on a protein called "apelin".1

This protein is not only a "key" that is different from insulin; it also passes through a different receptor or "doorway".

In type II diabetics where the receptor or doorway is impaired rather than the key, this discovery makes it possible to envisage effective treatment. The results observed by Philippe Valet's team make it possible to short-circuit this mechanism and achieve sugar assimilation by a completely different pathway from that mediated by insulin.

Normally, this second pathway is only responsible for a small proportion of sugar integration. However, as proved by tests conducted in mice by Inserm researchers, in the case of type II diabetes, activation of this second route improves the regulation of blood sugar levels. "We now have to check the action of this protein in man. In parallel, we are developing a synthetic molecule that may be used if the tests in man are positive," concluded Philippe Valet.


'/>"/>

Contact: Severine Ciancia
presse@inserm.fr
33-144-236-097
INSERM (Institut national de la sant et de la recherche mdicale)
Source:Eurekalert

Page: 1

Related biology news :

1. Can you rescue a rainforest? The answer may be yes
2. Rabbits to the rescue of the reef
3. Survey finds elevated rates of new asthma among WTC rescue and recovery workers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2017)... 2017 Today, American Trucking Associations announced ... face and eye tracking software, became the newest ... "Artificial intelligence and advanced sensing ... a driver,s attentiveness levels while on the road.  ... detect fatigue and prevent potential accidents, which could ...
(Date:5/16/2017)... DALLAS , May 16, 2017   ... for health organizations, and MD EMR Systems ... certified development partner for GE, have established a ... Patient Portal product and the GE Centricity™ products, ... Centricity EMR. These new integrations ...
(Date:4/17/2017)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the "Company"), ... Report on Form 10-K on Thursday April 13, 2017 with the ... The ... section of the Company,s website at http://www.nxt-id.com  under "SEC Filings," ... 2016 Year Highlights: Acquisition of ...
Breaking Biology News(10 mins):
(Date:7/17/2017)... , ... July 17, 2017 , ... ... company that has developed and intends both to manufacture and sell reagents used ... the NASDAQ Capital Market. , Headquartered in Sandy, Utah, Co-Diagnostics’ intellectual property and ...
(Date:7/16/2017)... ... July 16, 2017 , ... ... analytical instruments announced the launch of its new line of Extreme Environment Shakers ... applications that require CO2 and humidity for optimal cell growth such as cell ...
(Date:7/14/2017)... ... July 13, 2017 , ... Dr. Joshua Mondlick has ... implants into his practice, Mondlick Perio, in the Phoenix area. Dr. Mondlick ... first and only FDA cleared laser treatment to re-grow bone and with significantly less ...
(Date:7/13/2017)... ... July 13, 2017 , ... Thousands of pilots from across the country will ... Championships (Nats). Pilots come to Muncie to compete in various categories of model flying ... that participate in world championships. , RC Pylon (July 14-21): One of the most ...
Breaking Biology Technology: