Navigation Links
Apelin to rescue diabetics

Sugar is naturally present in the blood in the form of glucose and is stored in the liver or adipose tissue (fat) thanks to the action of insulin. Glucose is stored or directly used to ensure satisfactory function of the heart, brain and so on according to the body's demands.

In certain cases, this mechanism may deteriorate either because insulin is no longer produced (type 1 diabetes), or because the receptors located on the surface of liver cells are desensitized (type II diabetes). Consequently, the cell is no longer capable of assimilating glucose. Such a dysfunction causes a rise in blood sugar levels leading to the onset of numerous complications.

Philippe Valet's team has just found that our cells are equipped with a second pathway for the assimilation of glucose. This discovery is based on a protein called "apelin".1

This protein is not only a "key" that is different from insulin; it also passes through a different receptor or "doorway".

In type II diabetics where the receptor or doorway is impaired rather than the key, this discovery makes it possible to envisage effective treatment. The results observed by Philippe Valet's team make it possible to short-circuit this mechanism and achieve sugar assimilation by a completely different pathway from that mediated by insulin.

Normally, this second pathway is only responsible for a small proportion of sugar integration. However, as proved by tests conducted in mice by Inserm researchers, in the case of type II diabetes, activation of this second route improves the regulation of blood sugar levels. "We now have to check the action of this protein in man. In parallel, we are developing a synthetic molecule that may be used if the tests in man are positive," concluded Philippe Valet.


Contact: Severine Ciancia
INSERM (Institut national de la sant et de la recherche mdicale)

Page: 1

Related biology news :

1. Can you rescue a rainforest? The answer may be yes
2. Rabbits to the rescue of the reef
3. Survey finds elevated rates of new asthma among WTC rescue and recovery workers
Post Your Comments:
(Date:10/26/2015)... 2015  Delta ID Inc., a company focused on ... PC devices, announced its ActiveIRIS® technology powers the iris ... launched by NTT DOCOMO, INC in Japan ... smartphone to include iris recognition technology, after a very ... in May 2015, world,s first smartphone to have this ...
(Date:10/23/2015)... GOLETA, California , October 23, 2015 ... Instruments (SMI) announce a mobile plug and play integration ... interactive real-world tasks SensoMotoric Instruments (SMI) ... established wearable solutions for eye tracking and physiological data ... with SMI Eye Tracking Glasses 2w and ...
(Date:10/22/2015)... -- Synaptics (NASDAQ: SYNA ), a leading developer of human interface ... 30, 2015. --> --> ... percent over the comparable quarter last year to $470.0 million. Net ... or $0.62 per diluted share. --> ... fiscal 2016 grew 39 percent over the prior year period to ...
Breaking Biology News(10 mins):
(Date:11/27/2015)... /PRNewswire/--  Mallinckrodt plc (NYSE: MNK ), a ... closed the sale of its global contrast media and ... in a transaction valued at approximately $270 million. The ... total of approximately 1,000 employees spread across the globe, ... area. This entire workforce and the manufacturing ...
(Date:11/26/2015)... 26, 2015 ... Accutest Research Laboratories, a leading independent ... (CRO), has formed a strategic partnership ... Temple Health for joint work on ... ) , --> ...
(Date:11/25/2015)... ANNAPOLIS, Md. , Nov. 25, 2015  PharmAthene, ... of Directors has adopted a stockholder rights plan (Rights ... its net operating loss carryforwards (NOLs) under Section 382 ... --> --> PharmAthene,s use of its ... an "ownership change" as defined in Section 382 of ...
(Date:11/25/2015)... HOLLISTON, Mass. , Nov. 25, 2015 ... HART ), a biotechnology company developing bioengineered organ implants ... McGorry will present at the LD Micro "Main ... 2:30 p.m. PT. The presentation will be webcast live ... Management will also be available at the conference for ...
Breaking Biology Technology: