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Apelin hormone injections powerfully lower blood sugar
Date:11/4/2008

ernatively, obese animals and humans might grow resistant to the action of apelin just as they do insulin.

The researchers said they will now examine the effects of chronic apelin treatment in the mice to see if the hormone can ward of obesity and insulin resistance in the longer term.

" In conclusion," the researchers wrote, "the present study reveals apelin as a new endocrine regulator of AMPK and strengthens the crosstalk between [fat] and skeletal muscle. The involvement of AMPK in apelin-mediated glucose uptake represents an attractive pathway that could conceivably lead to a new drug target for the treatment of metabolic disorders."

Either way, they added, the discovery offers new insights into the physiology of glucose and lipid metabolism in health and disease.


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Contact: Cathleen Genova
cgenova@cell.com
617-397-2802
Cell Press
Source:Eurekalert

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