Navigation Links
Anything but modest: The mouse continues to contribute to humankind
Date:8/7/2008

Cambridge, UK, 07 August 2008 - "Big things come in small packages," the saying goes, and it couldn't be more true when discussing the mouse. This little creature has become a crucial part of human history through its contributions in understanding human genetics and disease. In a review published in Disease Models & Mechanisms (DMM), http://dmm.biologists.org, genetics researchers from Yale University School of Medicine and Fudan University School of Life Sciences discuss the history and future of mice as a model organism. They predict that the next frontiers in mouse genetics such as creating mice expressing human genes to create "humanized" mice will continue to provide scientists with new tools to not only decipher clinical mysteries, but also to test novel therapies and cures.

The review's authors, Duc Nguyen and Tian Xu, discuss the many ways in which scientists manipulate mouse genes in order to study their biology. One such technique that Nguyen and Xu are working on involves inserting a segment of DNA sequence into the much lengthier full genome of the mouse. These insertable DNA sequences are known as transposons. Use of transposons, as well as other genetic tools, allows scientists to disrupt a specific mouse gene and deduce the gene's function by studying the effect on the mouse. The hope is that the research community can combine the results of extensive mouse studies into a comprehensive library to form a functional map of the mouse genome. Such a map will help researchers navigate and explore the even more extensive human genome to pinpoint the genetic underpinnings of human disease.

Not only do the researchers discuss how mice help us understand disease, but they also highlight methods which enable research of novel disease therapies. For example, humanized mice mice engineered to carry human genes can provide new experimental systems for testing new therapeutics.


'/>"/>

Contact: Donna Perry
donna@biologists.com
44-122-342-6164
The Company of Biologists
Source:Eurekalert

Page: 1

Related biology news :

1. A computer for your mouse!
2. Immune cells promote blood vessel formation in mouse endometriosis
3. Cancer-resistant mouse discovered
4. Looking through the eyes of a mouse, scientists monitor circulating cells in its bloodstream
5. New chimeric mouse model for human liver diseases, drug testing
6. CSHL scientists identify and repress breast cancer stem cells in mouse tissue
7. Dissecting the genetic components of adaptation of E. coli to the mouse gut
8. Book is the first high-resolution digital mouse brain atlas designed for Web applications
9. Scientists successfully treat new mouse model of inflammatory bowel disease
10. Negligent, attentive mouse mothers show biological differences
11. Mouse study: When it comes to living longer, its better to go hungry than go running
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/1/2016)... -- Favorable Government Initiatives Coupled With Implementation ... to Boost Global Biometrics System Market Through 2021  ... " Global Biometrics Market By Type, By End ... - 2021", the global biometrics market is projected to ... growing security concerns across various end use sectors such ...
(Date:5/9/2016)... 2016 Elevay is currently known ... freedom for high net worth professionals seeking travel for ... connected world, there is still no substitute for a ... sealing your deal with a firm handshake. This is ... advantage of citizenship via investment programs like those offered ...
(Date:4/26/2016)... -- Research and Markets has announced the ...  report to their offering.  , ,     (Logo: ... forecast the global multimodal biometrics market to grow ... 2016-2020.  Multimodal biometrics is being implemented ... healthcare, BFSI, transportation, automotive, and government for controlling ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... June 24, 2016 Epic Sciences unveiled ... cancers susceptible to PARP inhibitors by targeting homologous ... (CTCs). The new test has already been incorporated ... multiple cancer types. Over 230 clinical ... response pathways, including PARP, ATM, ATR, DNA-PK and ...
(Date:6/23/2016)... ... 2016 , ... Mosio, a leader in clinical research patient ... and Retention Tips.” Partnering with experienced clinical research professionals, Mosio revisits the hurdle ... and strategies for clinical researchers. , “The landscape of how patients receive and ...
(Date:6/23/2016)... 23, 2016 /PRNewswire/ - FACIT has announced the ... biotechnology company, Propellon Therapeutics Inc. ("Propellon" or ... of a portfolio of first-in-class WDR5 inhibitors for ... as WDR5 represent an exciting class of therapies, ... medicine for cancer patients. Substantial advances have been ...
(Date:6/23/2016)... ... 2016 , ... Charm Sciences, Inc. is pleased to announce ... Research Institute approval 061601. , “This is another AOAC-RI approval of the Peel ... President of Regulatory and Industrial Affairs. “The Peel Plate methods perform comparably to ...
Breaking Biology Technology: