Navigation Links
Antiviral enzyme contributes to several forms of cancer, University of Minnesota researchers say
Date:7/14/2013

Researchers at the University of Minnesota have discovered that a human antiviral enzyme causes DNA mutations that lead to several forms of cancer.

The discovery, reported in the July 14 issue of Nature Genetics, follows the team's earlier finding that the enzyme, called APOBEC3B, is responsible for more than half of breast cancer cases. The previous study was published in Nature in February.

APOBEC3B is part of a family of antiviral proteins that Harris has studied for more than a decade. His effort to understand how these proteins work has led to these surprising discoveries that APOBEC3B is a broadly important cancer mutagen.

"We are very excited about this discovery because it indicates that a single enzyme is one of the largest known contributors to cancer mutation, possibly even eclipsing sources such as UV rays from the sun and chemicals from smoking," says Reuben Harris, a professor of biochemistry, molecular biology and biophysics based in the College of Biological Sciences. Harris, who led the study, is also a member of the Masonic Cancer Center, University of Minnesota.

For the current study, Harris, along with colleagues Michael Burns and Alpay Temiz, analyzed tumor samples from 19 different types of cancer for the presence of APOBEC3B and 10 related proteins. Results showed that APOBEC3B alone was significantly elevated in six types (bladder, cervix, two forms of lung cancer, head & neck, and breast). Levels of the enzyme, which is present in low levels in most healthy tissues, were elevated in several other types of cancer as well.

A second key finding was that the mutational signature of APOBEC3B is a close match to the actual mutation pattern in these cancers. "Much like we each have unique written signatures, these enzymes each leave a unique mark," Harris says.

Findings from both studies are counterintuitive because the enzyme, which is produced by the immune system, is supposed to p
'/>"/>

Contact: Peggy Rinard
rinar001@umn.edu
612-624-0774
University of Minnesota
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scientists identify promising antiviral compounds
2. Toward broad-spectrum antiviral drugs for common cold and other infections
3. Synthetic derivatives of THC may weaken HIV-1 infection to enhance antiviral therapies
4. Antiviral lipid earns patent
5. Novel enzyme from tiny gribble could prove a boon for biofuels research
6. Combining strategies speeds the work of enzymes
7. Protein improves efficacy of tumor-killing enzyme
8. Enzymes allow DNA to swap information with exotic molecules
9. DNA catalysts do the work of protein enzymes
10. Researchers divide enzyme to conquer genetic puzzle
11. Organizing enzymes to create electricity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... many sobering examples of how wildlife loss leads to ... co-authored by Wildlife Conservation Society (WCS) Health & ... Golden, calls for an interdisciplinary approach to tackle global ... supports about 15% of the world,s people and provides ... poor. It should come as no surprise that today,s ...
(Date:7/24/2014)... have decreased by 45% on average over a 35 ... a study on the impact of humans on declining ... benefits invertebrates such as insects, spiders, crustaceans, slugs and ... pest control for crops, decomposition for nutrient cycling, water ... Science and led by UCL, Stanford and ...
(Date:7/24/2014)... June 24, 2014 Some sticky research out of ... against a certain species of toxic grass fungus: moose ... month,s Biology Letters , "Ungulate saliva inhibits a ... applied to red fescue grass (which hosts a fungus ... in slower fungus growth and less toxicity. , "Plants ...
Breaking Biology News(10 mins):New study draws links between wildlife loss and social conflicts 2Invertebrate numbers nearly halve as human population doubles 2Invertebrate numbers nearly halve as human population doubles 3Moose drool inhibits growth of toxic fungus: York U research 2
... Portage Glacier, AK The historic collaboration between leading ... the Center for Health and the ,Global Environment at ... ,Evangelicals (NAE) continues this week with a trip to ... leaders began traveling together on August 25th to observe ...
... living donor transplantation are continuously happening in hospitals. One ... 14 issue of the World Journal of Gastroenterology because ... going to bring comfort to many families. It ... Ichikawa in the Nagasaki University Hospital, Japan in 2004. ...
... technique for testing public drinking water samples for the ... the amount of time required to conduct the sampling ... Agency (EPA) has approved use of the new testing ... director of the Georgia Tech Research Institutes (GTRI) Environmental ...
Cached Biology News:Scientist-evangelical Alaska expedition 2Clearance of hepatitis C viral infection after liver transplantation 2Safe water: simpler method for analyzing radium in water samples cuts testing time 2Safe water: simpler method for analyzing radium in water samples cuts testing time 3
(Date:7/25/2014)... July 25, 2014 The Conferee Networking ... Topics for Conferee Networking. These two-hour sessions provide a ... meet and resolve problems, discuss new techniques, or brainstorm ... to submit a topic for consideration is August 31, ... . The Conferee Networking committee will review the topics, ...
(Date:7/25/2014)... , July 25, 2014  Galmed Pharmaceuticals Ltd. ... company focused on the development and commercialization of a ... and cholesterol gallstones, today announced financial results for the ... 2014 Financial Summary: , Reported cash and cash ... with $137,000 at December 31, 2013.  , Reported ...
(Date:7/25/2014)... July 25, 2014 At the request ... granted a 60-day extension for the public comment period ... Rule for Model Aircraft established by Congress as part ... The 60-day extension establishes the new deadline for comments ... Department of Transportation/FAA notice published in the Federal Register ...
(Date:7/24/2014)... July 24, 2014 -- Keryx Biopharmaceuticals, Inc. (Nasdaq:KERX) (the ... randomized, active control Phase 3 study of Zerenex (ferric ... for the treatment of hyperphosphatemia in patients with end-stage ... binding and iRon delivery with FErric CiTrate in EsrD) ... the American Society of Nephrology ( JASN ). ...
Breaking Biology Technology:Pittcon 2015 Announces Call for Topics for Conferee Networking Sessions 2Galmed Pharmaceuticals Reports First Half 2014 Financial Results 2Galmed Pharmaceuticals Reports First Half 2014 Financial Results 3Galmed Pharmaceuticals Reports First Half 2014 Financial Results 4Galmed Pharmaceuticals Reports First Half 2014 Financial Results 5Galmed Pharmaceuticals Reports First Half 2014 Financial Results 6FAA Grants Comment Extension at the Request of AMA 2Zerenex (ferric citrate) long-term Phase 3 study results published in JASN 2Zerenex (ferric citrate) long-term Phase 3 study results published in JASN 3Zerenex (ferric citrate) long-term Phase 3 study results published in JASN 4
... BOTHELL, Wash., Nov. 18 BioLife Solutions, Inc. (OTC Bulletin ... cGMP hypothermic storage and cryopreservation media products for cells, tissues, ... Japanese patent for an application that includes claims related to ... used in biopreservation. The patent is titled " Inclusion of ...
... ... for irregular warfare--for combat, and just as importantly, for civic operations designed to gain ... to December 3. , ... Orlando, FL (Vocus) November 18, 2009 -- As the President nears a decision ...
... ... report. WellGen is developing propeirtary nutraceuticals for medical foods, a market described as a ... ... released industry analysis highlights WellGen, Inc. as an important innovator in a high growth market. ...
Cached Biology Technology:BioLife Solutions Granted Japanese Biopreservation Patent 2BioLife Solutions Granted Japanese Biopreservation Patent 3Huge Exhibition to Demonstrate Training for Irregular Warfare 2Huge Exhibition to Demonstrate Training for Irregular Warfare 3WellGen Recognized as Nutraceutical “Innovator” by Global Business Insights 2WellGen Recognized as Nutraceutical “Innovator” by Global Business Insights 3
... FL ATP-Gamma-S binds to ATP-binding proteins. ... BODIPY FL fluorophore was linked through ... to its potential use for binding ... is an important new substrate for ...
... the world of discovery races ever faster, you ... the fast track. So our constant focus is ... your research. Thats why our Biomek 3000 Laboratory ... as advanced as it is flexible. By integrating ...
... industry standard microarray image analysis software because ... analysis tools, visualizations, automation capabilities, performance and ... with every GenePix scanner, and it also ... all types of arrays. A wide range ...
... Arrays contain 60 rabbit tissue samples arrayed on ... unstained slides and 1 hematoxylin and eosin (H&E) ... 15 different tissues from 4 rabbit organisms, for ... Each tissue sample (or core) is 1.5 mm ...
Biology Products: