Navigation Links
Antipsychotic drug may be helpful treatment for anorexia nervosa
Date:4/4/2012

Low doses of a commonly used atypical antipsychotic drug improved survival in a mouse model of anorexia nervosa, University of Chicago researchers report this month. The result offers promise for a common and occasionally fatal eating disorder that currently lacks approved drugs for treatment.

Mice treated with small doses of the drug olanzapine were more likely to maintain their weight when given an exercise wheel and restricted food access, conditions that produce activity-based anorexia (ABA) in animals. The antidepressant fluoxetine, commonly prescribed off-label for anorexic patients, did not improve survival in the experiment.

"We found over and over again that olanzapine was effective in harsher conditions, less harsh conditions, adolescents, adults it consistently worked," said the paper's first author Stephanie Klenotich, graduate student in the Committee on Neurobiology at the University of Chicago Biological Sciences.

The study, published in Neuropsychopharmacology, was the product of a rare collaboration between laboratory scientists and clinicians seeking new treatment options for anorexia nervosa. As many as one percent of American women will suffer from anorexia nervosa during their lifetime, but only one-third of those people will receive treatment.

Patients with anorexia are often prescribed off-label use of drugs designed for other psychiatric conditions, but few studies have tested the drugs' effectiveness in animal models.

"Anorexia nervosa is the most deadly psychiatric disorder, and yet no approved pharmacological treatments exist," said Stephanie Dulawa, PhD, assistant professor of Psychiatry & Behavioral Neuroscience at the University of Chicago Medicine and senior author of the study. "One wonders why there isn't more basic science work being done to better understand the mechanisms and to identify novel pharmacological treatments."

One challenge is finding a medication that patie
'/>"/>

Contact: Robert Mitchum
robert.mitchum@uchospitals.edu
773-795-5227
University of Chicago Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. The importance of being helpful -- Cooperative cichlids boost their own reproductive success
2. Helpful yeast battles food-contaminating aflatoxin
3. Fertilizer use not always helpful in revegetation efforts
4. When helper cells arent helpful
5. Fast-food menu calorie counts legally compliant but not as helpful to consumers as they should be
6. Breast cancer treatment resistance linked to signaling pathway
7. The dietary supplement genistein can undermine breast cancer treatment
8. Coming soon: Self-guided, computer-based depression treatment
9. Nanodiamond drug device could transform cancer treatment
10. Disinfectants can make bacteria resistant to treatment
11. Scientists from Granada find a potential treatment to prevent diabetes and obesity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... method for delivering compounds that could positively ... AIDS may be possible, thanks to researchers ... A semi-soft vaginal suppository made from the ... the antiviral drug Tenofovir provides a woman-initiated, ... spread of sexually transmitted infections during unprotected ...
(Date:8/28/2014)... than 25 million kilometres of new roads will be ... slice into Earth,s last wildernesses, where they bring an ... , Now, an ambitious study has created a ,global ... try to balance the competing demands of development and ... ,environmental-values, layer that estimates that natural importance of ecosystems ...
(Date:8/28/2014)... areas conserve biodiversity and more action is needed to ... researchers say. , Published in PLOS ONE , ... of Exeter, used meta-analysis - combining results from different ... of research into these areas, to determine whether they ... of Biological Sciences, said protecting an area from human ...
Breaking Biology News(10 mins):Sensory-tested drug-delivery vehicle could limit spread of HIV, AIDS 2Sensory-tested drug-delivery vehicle could limit spread of HIV, AIDS 3Study shows where on the planet new roads should and should not go 2Study shows where on the planet new roads should and should not go 3Protected areas proven to protect biodiversity 2
... you are a rice breeder and one day within a ... characteristics you have been looking for. You happily take your ... the spontaneous, beneficial event was due to inactivation of a ... many different strains grown in different parts of the world, ...
... biometric products and expanded markets, JERICHO, N.Y., ... and Oki Semiconductor Company, a division of Oki,America ... Industry Co, Ltd.,jointly announced that they are working ... significantly lowering bioMETRX,s overall build costs for,its expanding ...
... The song of passerine birds is a conspicuous and ... of male-male competition or mate attraction. At the level ... male quality. Paola Laiolo and colleagues at ... system of the Duponts lark in north-eastern Spain and ...
Cached Biology News:Less can be more, for plant breeders too 2Less can be more, for plant breeders too 3bioMETRX Incorporates OKI's Fingerprint Engine in its smartTOUCH Product Line 2bioMETRX Incorporates OKI's Fingerprint Engine in its smartTOUCH Product Line 3
(Date:8/29/2014)... are based on electrons, but one of the most ... i.e. circuits based on light (photons) instead of electrons. ... a stream of single photons and control their direction. ... attempts to achieve this control, but now scientists at ... steady stream of photons emitted one at a time ...
(Date:8/29/2014)... 2014 Local veterinarian, Dr. Keith Clement, ... seeking candidates to participate in an investigational study of ... ultimate goal of this study is to determine if ... or two arthritically affected joints can help reduce pain ... for the current investigational study must be older than ...
(Date:8/28/2014)... DIEGO, California, USA (PRWEB) August 28, 2014 ... the Department of Physics and Optical Science and Director ... the University of North Carolina at Charlotte, and co-founder ... been elected to serve as the 2015 Vice President ... , SPIE 2014 President Philip Stahl announced recent election ...
(Date:8/28/2014)... devices in spintronics, an electronic which is not ... also on their spin and the spin-related magnetism. ... magnetic signals and vice versa. Recently, the research ... of Physics at Johannes Gutenberg University Mainz in ... Japan, has for the first time realised a ...
Breaking Biology Technology:Breakthrough in light sources for new quantum technology 2Burnt Hills Veterinary Hospital Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2Glenn Boreman, UNC Professor and Plasmonics Co-Founder, Elected to SPIE Presidential Chain 2A new, tunable device for spintronics 2A new, tunable device for spintronics 3
... catalysts and video displays are among the potential applications ... These particles are named after the two-faced Roman god ... form novel structures and new materials. However, as scientists ... a few nanometers in diameter about the size ...
... Pa., Sept. 27, 2011 Renmatix , ... the Plantrose™ process, the company,s commercial approach to ... to non-food derived low-cost industrial sugars, the foundation ... dramatic shift from petroleum-based fuels and chemicals to ...
... be coming to a little screen near you. These ... of displaying information on cell phones, e-readers and iPads, and ... solar cells, according to new research. Duke chemist Ben ... organize copper atoms in water to form long, thin, non-clumped ...
Cached Biology Technology:New technique maps twin faces of smallest Janus nanoparticles 2Renmatix Reveals Supercritical Hydrolysis as Lowest-Cost Pathway to Cellulosic Sugar 2Renmatix Reveals Supercritical Hydrolysis as Lowest-Cost Pathway to Cellulosic Sugar 3Copper film could lower touch screen, led and solar cell costs 2
... dedicated imaging system for fluorescent light due ... very sensitive camera to detect low level ... research, infectious disease research, gene expression, circadian ... the only imager with a motor-driven camera ...
Mouse polyclonal antibody raised against a partial recombinant IFNA13. NCBI Entrez Gene ID = 3447...
... Mouse polyclonal antibody raised ... Immunogen: ... 646 a.a) partial recombinant protein ... Accession Number: NM_006842 ...
Mouse monoclonal antibody to UGT2B10 - UDP glucuronosyltransferase 2 family, polypeptide B10...
Biology Products: