Navigation Links
Antioxidants in pregnancy prevent obesity in animal offspring
Date:3/14/2011

New biological research may be relevant to the effects of a mother’s high-fat diet during pregnancy on the development of obesity in her children.

An animal study at The Children’s Hospital of Philadelphia suggests that a high-fat, high-carbohydrate diet causes oxidative stress—an excess of deleterious free radicals—during pregnancy, predisposing the offspring to obesity and diabetes. Feeding rats antioxidants before and during pregnancy completely prevented obesity and glucose intolerance in their offspring.

If the results in animals prove to be similar in humans, the research may have implications for reducing obesity rates in children. “We already know that there are critical periods during human development that influence the later development of obesity,” said senior author Rebecca A. Simmons, M.D., a neonatologist at The Children’s Hospital of Philadelphia. “This research suggests that if we can prevent inflammation and oxidative stress during pregnancy, we may lower the risk that a child will develop obesity.”

The study by Simmons and co-author Sarbattama Sen, M.D., was published in the December 2010 print edition of Diabetes.

Oxidative stress is a condition in which quantities of highly reactive oxygen-containing molecules (free radicals and other chemicals) exceed the body’s ability to control their biological damage to cells. It is already known that obesity in people contributes to oxidative stress, in part by causing inflammation. Furthermore, obesity during pregnancy creates an abnormal metabolic environment during human gestation.

The current study tested the hypothesis that a high-fat diet during pregnancy increases oxidative stress and leads to obesity in the offspring of animals. Simmons and Sen also investigated whether supplementing the animals’ diet with antioxidants would prevent obesity in the offspring.

The researchers simulated a Western-style diet by feeding high-fat, high-carbohydrate chow to one group of rats, compared to a control group fed a more balanced diet. In two other groups (one fed a Western diet, the other fed a control diet), the researchers added antioxidant vitamins.

Among the rats that ate only the Western diet, the offspring had significantly higher measures of inflammation and oxidative stress, and as early as two weeks of age, were significantly fatter, with impaired glucose tolerance compared to control rats. However, rats eating the Western diet plus antioxidants had offspring with significantly lower oxidative stress, as well as no obesity and significantly better glucose tolerance. The effects persisted at two months of age.

“These results suggest that if we prevent obesity, inflammation and oxidative stress in pregnant animals, we can prevent obesity in the offspring,” said Simmons. Simmons added that a next step in this research is to determine the mechanisms by which inflammation and oxidative stress cause more fat tissue to develop.

She cautioned that until these effects are carefully studied in people, one shouldn’t conclude that the biological effects seen in animals are the same in humans. In the meantime, she added that, whether pregnant or not, women should certainly not conclude from this study that they should consume large doses of antioxidant vitamins.


'/>"/>

Contact: John Ascenzi
Ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
Source:Eurekalert

Related biology news :

1. Preterm mothers milk contains less antioxidants than mothers completing their gestation
2. Jefferson researchers provide genetic evidence that antioxidants can help treat cancer
3. Roasting coffee beans a dark brown produces valued antioxidants: UBC food scientists
4. Concerns about the safety of certain healthful plant-based antioxidants
5. Polyphenol antioxidants inhibit iron absorption
6. Want to slow aging? New research suggests it takes more than antioxidants
7. Antioxidants do help arteries stay healthy
8. Well-defined quantity of antioxidants in diet can improve insulin resistance
9. University of Colorado study shows natural antioxidants give top barn swallows a leg on competitors
10. Antioxidants arent always good for you and can impair muscle function, study shows
11. Scientists discover influenzas Achilles heel: Antioxidants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/7/2016)... 2016  Syngrafii Inc. and San Antonio Credit ... includes integrating Syngrafii,s patented LongPen™ eSignature "Wet" solution ... will result in greater convenience for SACU members ... maintaining existing document workflow and compliance requirements. ... Highlights: ...
(Date:6/2/2016)... 2016 The Department of Transport Management ... 44 million US Dollar project, for the , ... Personalization, Enrolment, and IT Infrastructure , to ... and implementation of Identity Management Solutions. Numerous renowned international vendors ... Decatur was selected for the most compliant and ...
(Date:6/2/2016)... June 2, 2016 Perimeter Surveillance ... Unmanned Systems, Physical Infrastructure, Support & Other Service  ... visiongain offers comprehensive analysis of the global ... will generate revenues of $17.98 billion in 2016. ... Inc, a leader in software and hardware technologies for ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... ... June 24, 2016 , ... While the majority of commercial spectrophotometers and ... and the 6000i models are higher end machines that use the more unconventional z-dimension ... light beam from the bottom of the cuvette holder. , FireflySci has developed ...
(Date:6/23/2016)... TORONTO , June 23, 2016 /PRNewswire/ - ... Ontario biotechnology company, Propellon ... the development and commercialization of a portfolio of ... cancers. Epigenetic targets such as WDR5 represent an ... contribute significantly in precision medicine for cancer patients. ...
(Date:6/23/2016)... June, 23, 2016  The Biodesign Challenge (BDC), a ... ways to harness living systems and biotechnology, announced its ... in New York City . ... students, showcased projects at MoMA,s Celeste Bartos Theater during ... , MoMA,s senior curator of architecture and design, and ...
(Date:6/23/2016)... June 23, 2016 Apellis Pharmaceuticals, Inc. ... clinical trials of its complement C3 inhibitor, APL-2. ... multiple ascending dose studies designed to assess the ... subcutaneous injection in healthy adult volunteers. ... as a single dose (ranging from 45 to ...
Breaking Biology Technology: