Navigation Links
Antioxidants in pregnancy prevent obesity in animal offspring
Date:3/14/2011

New biological research may be relevant to the effects of a mother’s high-fat diet during pregnancy on the development of obesity in her children.

An animal study at The Children’s Hospital of Philadelphia suggests that a high-fat, high-carbohydrate diet causes oxidative stress—an excess of deleterious free radicals—during pregnancy, predisposing the offspring to obesity and diabetes. Feeding rats antioxidants before and during pregnancy completely prevented obesity and glucose intolerance in their offspring.

If the results in animals prove to be similar in humans, the research may have implications for reducing obesity rates in children. “We already know that there are critical periods during human development that influence the later development of obesity,” said senior author Rebecca A. Simmons, M.D., a neonatologist at The Children’s Hospital of Philadelphia. “This research suggests that if we can prevent inflammation and oxidative stress during pregnancy, we may lower the risk that a child will develop obesity.”

The study by Simmons and co-author Sarbattama Sen, M.D., was published in the December 2010 print edition of Diabetes.

Oxidative stress is a condition in which quantities of highly reactive oxygen-containing molecules (free radicals and other chemicals) exceed the body’s ability to control their biological damage to cells. It is already known that obesity in people contributes to oxidative stress, in part by causing inflammation. Furthermore, obesity during pregnancy creates an abnormal metabolic environment during human gestation.

The current study tested the hypothesis that a high-fat diet during pregnancy increases oxidative stress and leads to obesity in the offspring of animals. Simmons and Sen also investigated whether supplementing the animals’ diet with antioxidants would prevent obesity in the offspring.

The researchers simulated a Western-style diet by feeding high-fat, high-carbohydrate chow to one group of rats, compared to a control group fed a more balanced diet. In two other groups (one fed a Western diet, the other fed a control diet), the researchers added antioxidant vitamins.

Among the rats that ate only the Western diet, the offspring had significantly higher measures of inflammation and oxidative stress, and as early as two weeks of age, were significantly fatter, with impaired glucose tolerance compared to control rats. However, rats eating the Western diet plus antioxidants had offspring with significantly lower oxidative stress, as well as no obesity and significantly better glucose tolerance. The effects persisted at two months of age.

“These results suggest that if we prevent obesity, inflammation and oxidative stress in pregnant animals, we can prevent obesity in the offspring,” said Simmons. Simmons added that a next step in this research is to determine the mechanisms by which inflammation and oxidative stress cause more fat tissue to develop.

She cautioned that until these effects are carefully studied in people, one shouldn’t conclude that the biological effects seen in animals are the same in humans. In the meantime, she added that, whether pregnant or not, women should certainly not conclude from this study that they should consume large doses of antioxidant vitamins.


'/>"/>

Contact: John Ascenzi
Ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
Source:Eurekalert

Related biology news :

1. Preterm mothers milk contains less antioxidants than mothers completing their gestation
2. Jefferson researchers provide genetic evidence that antioxidants can help treat cancer
3. Roasting coffee beans a dark brown produces valued antioxidants: UBC food scientists
4. Concerns about the safety of certain healthful plant-based antioxidants
5. Polyphenol antioxidants inhibit iron absorption
6. Want to slow aging? New research suggests it takes more than antioxidants
7. Antioxidants do help arteries stay healthy
8. Well-defined quantity of antioxidants in diet can improve insulin resistance
9. University of Colorado study shows natural antioxidants give top barn swallows a leg on competitors
10. Antioxidants arent always good for you and can impair muscle function, study shows
11. Scientists discover influenzas Achilles heel: Antioxidants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/20/2016)... , Jan. 20, 2016   MedNet Solutions ... the entire spectrum of clinical research, is pleased to ... MedNet,s significant achievements are the result of the company,s ... iMedNet eClinical , it,s comprehensive, easy-to-use and ... --> Key MedNet growth achievements in ...
(Date:1/18/2016)... Jan. 18, 2016  Extenua Inc., a pioneering ... the use and access of ubiquitous on-premise and ... with American Cyber.  ... leading transformational C4ISR and Cyber initiatives in support ... latest proven technology solutions," said Steve Visconti ...
(Date:1/13/2016)... ALBANY, New York , January 13, 2016 /PRNewswire/ ... Transparency Market Research has published a new market report ... Share, Growth, Trends, and Forecast, 2015 - 2023. According to ... mn in 2014 and is anticipated to reach US$1,625.8 ... from 2015 to 2023. In terms of volume, the ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... BEACH, Florida , February 11, 2016 /PRNewswire/ ... PositiveID Corporation ("PositiveID" or "Company") (OTCQB: PSID), ... diagnostics, announced today that its Thermomedics subsidiary, which ... progress on its growth plan in January 2016, ... products distributors, increasing sequential monthly sales growth, and ...
(Date:2/10/2016)... , Febr. 10, 2016 /PRNewswire/ - BioAmber Inc. (NYSE: ... pleased to announce that Mitsui & Co. Ltd., its ... succinic acid plant, is investing an additional CDN$25 million ... increasing its stake from 30% to 40%.  Mitsui will ... bio-succinic acid produced in Sarnia , ...
(Date:2/10/2016)... , ... February 10, 2016 ... ... today announced that it has joined the Human Vaccines Project, a public-private ... diseases and cancer. , The Human Vaccines Project brings together leading ...
(Date:2/10/2016)... Springfield, MO (PRWEB) , ... February 10, 2016 ... ... company, will attend the International Society of Pharmaceutical Engineering (ISPE) Rocky Mountain Chapter ... of ISPE is expecting to fill more than 100 tables for its annual ...
Breaking Biology Technology: