Navigation Links
Antioxidants could provide all-purpose radiation protection
Date:11/4/2007

SINGAPORE -- Two common dietary molecules found in legumes and bran could protect DNA from the harmful effects of radiation, researchers from the University of Maryland report. Inositol and inositol hexaphosphate (IP6) protected both human skin cells and a skin cancer-prone mouse from exposure to ultraviolet B (UVB) radiation, the damaging radiation found in sunlight, the team reported today at the American Association for Cancer Research Centennial Conference on Translational Cancer Medicine.

According to the researchers, inositol and IP6 could decrease the severity of side effects from radiation therapy, saving healthy cells while simultaneously increasing the potency of the treatment against cancer cells. Both molecules are potent antioxidants, the Maryland researchers say, capable of preventing reactive molecules from injuring DNA and turning cells cancerous.

Both of these potent antioxidants have been shown to have broad-spectrum anti-tumor capabilities, and now our studies confirm the degree to which these molecules protect against the DNA-damaging effects of ionizing radiation, said Abulkalam M. Shamsuddin, M.D., professor of pathology at the University of Maryland School of Medicine. Radiation damage is radiation damage, regardless of the source, so there could also be a protective role for IP6 in any form of radiation exposure, whether it is from a therapeutic dose or from solar, cosmic or nuclear sources.

While both inositol and IP6 are related to B vitamins, they are not considered essential dietary nutrients. In the 1980s, however, researchers discovered that these molecules, abundant within the hulls of seeds and grains, had definitive protective effects against colorectal cancer.

Inspired by reports of a clinical trial begun in 2001 at Clinical Hospital in Split, Croatia, which suggested IP6 enhanced the effectiveness of radiotherapy while lessening the side effects, Shamsuddin and his colleagues sought to inve
'/>"/>

Contact: Staci Vernick Goldberg
staci.goldberg@aacr.org
267-646-0616
American Association for Cancer Research
Source:Eurekalert

3

GOOD

Page: 1 2 3

Related biology news :

1. Red delicious, Northern Spy apples have most antioxidants, chemists find
2. Free-radical busting antioxidants might not promote healthy hearts
3. Unique tomatoes tops in disease-fighting antioxidants
4. Honeydew honeys are better antioxidants than nectar honeys
5. Pistachios lower cholesterol, provide antioxidants
6. ASU research shows connection between testosterone, dietary antioxidants and bird coloration
7. Protein discovery could unlock the secret to better TB treatment
8. Tiny particles could solve billion-dollar problem
9. Novel Therapy Tested in Mice Could Chase Away Cat Allergies
10. Spider Venom Could Yield Eco-Friendly Insecticides
11. First atlas of key brain genes could speed research on cancer, neurological diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/20/2013)... to the antibiotic colistin are also commonly resistant ... according to a study in mBio , ... for Microbiology. Cross-resistance to colistin and host antimicrobials ... against bacterial attack, could mean that patients with ... a crippled immune response. Colistin is a last-line ...
(Date:5/20/2013)... the effect of physical education (PE) on child weight, ... increasing the amount of time that elementary schoolchildren spent ... The study represents some of the first evidence of ... is forthcoming in the Journal of Health Economics ... can be viewed at: http://www.sciencedirect.com/science/article/pii/S0167629613000556 , The ...
(Date:5/20/2013)... a compound abundant in the Mediterranean diet takes away ... altering a very specific step in gene regulation, this ... die as scheduled. , One way that cancer cells ... them to die on a regular cycle that is ... by Ohio State University researchers, found that a compound ...
Breaking Biology News(10 mins):Resistance to last-line antibiotic makes bacteria resistant to immune system 2Resistance to last-line antibiotic makes bacteria resistant to immune system 3Gym class reduces probability of obesity, study finds for first time 2The compound in the Mediterranean diet that makes cancer cells 'mortal' 2The compound in the Mediterranean diet that makes cancer cells 'mortal' 3
... The development of a new cell-culture system that ... become coated with protective myelin opens up new avenues ... myelin regulates a key protein involved in sending long-distance ... characterized by damage to the myelin sheath surrounding nerve ...
... 2011 -- Surface water quality is important for the ... needs and recreation. Pasturelands have been found to be ... surface water resources. While poor grazing management may lead ... specific amount of pollution in pasture streams that can ...
... Exonhit (Alternext: ALEHT), a biotech company focused on ... are pleased to announce the successful completion of a ... to an additional strategic preclinical animal model species. ... gene deregulation and the expanding interest in developing biomarkers ...
Cached Biology News:MS research: Myelin influences how brain cells send signals 2MS research: Myelin influences how brain cells send signals 3MS research: Myelin influences how brain cells send signals 4Grazing management effects on stream pollutants 2
(Date:5/20/2013)... With bed bugs' presence come problems in ... bugs need to be eliminated, one must make sure that ... health. And so to help bed bug sufferers get that ... of bed bugs without using harmful pesticides. In it, ... called Bed Bug Bully. , According to My Cleaning Products, ...
(Date:5/20/2013)... , May 20, 2013 Cempra, ... on developing differentiated antibiotics to meet critical medical ... announced that it presented data at the American ... Philadelphia demonstrating the antibacterial and ... Cempra,s prior Phase 2 clinical trial in outpatients ...
(Date:5/20/2013)... 2013 Rhythm announced today the results of ... company,s novel ghrelin agonist for the treatment of diabetic ... that RM-131 significantly accelerates early gastric emptying and reduces ... with diabetic gastroparesis. The findings were presented at the ... and recently published in Clinical Gastroenterology ...
(Date:5/20/2013)... Researchers from the Southern University of ... back pain, and the acne causing P.acnes bacteria. Researchers believe ... bacteria seek out oxygen deprived location to seek shelter and ... P.acnes has the ability to live in the open joint ... spokesman for “ The best acne treatment ” explains why ...
Breaking Biology Technology:New Non Pesticide Discovery on How to Get Rid of Bed Bugs Tipped by My Cleaning Products 2Cempra Presents Post-Phase 2 Analysis of Solithromycin's Efficacy and Safety Results from Patients with Community Acquired Bacterial Pneumonia (CABP) 2Rhythm Announces Phase 1b Results for Ghrelin Prokinetic RM-131 for Gastroparesis in Patients with Type 1 Diabetes 2Rhythm Announces Phase 1b Results for Ghrelin Prokinetic RM-131 for Gastroparesis in Patients with Type 1 Diabetes 3Adult Acne Treatment, Probiotic Action Shares New Insight How Treating Acne May Help Reduce Body Pain 2
... ... best available tool for the analysis of metabolites in plants , ... Amsterdam, The Netherlands (PRWEB) June 28, 2010 -- Genedata, ... demo the new Refiner MS at the 6th Metabolomics Conference 2010. Part of ...
... India , June 28, 2010 Shivsu Canadian Clear,International Ltd, a ... from the private organizations and,Government of Africa to set up ... Ethiopia . The company will be involved in design,manufacture, supply and installation of ... ...
... ... Leads the Way as First in Arizona ,with State of the Art 3D Dedicated ... ... Center is the first institution in the state of Arizona to adopt TrueVision® 3D ...
Cached Biology Technology:Genedata's Refiner MS Used by Max Planck Institute will Demo at Metabolomics Conference 2010 2Genedata's Refiner MS Used by Max Planck Institute will Demo at Metabolomics Conference 2010 3Genedata's Refiner MS Used by Max Planck Institute will Demo at Metabolomics Conference 2010 4Indian Multinational Company Confirms USD 6 Million Order to Set up Industrial Waste Water Treatment Plants in Africa 2Indian Multinational Company Confirms USD 6 Million Order to Set up Industrial Waste Water Treatment Plants in Africa 3Cardon Children's Medical Center Adopts TrueVision 3D Surgical Visualization Platform for Department of Pediatric Neurosurgery 2
... G|2 Doublestain System is a high-sensitivity ... kit. The kit is intended for ... detection of two different antigens within ... with suitably diluted rabbit and mouse ...
AVOID FREEZE/THAW CYCLES. Recognizes the UCP-2 protein....
Rabbit Anti-Human Janus Kinase 2 (JAK2 Polyclonal Antibody Family: Protein Kinase Sub-Family: TYK2/JAK Applications: ELISA, Western Blot...
MAb to HSV-2, gG-2 HSV-2 Glycoprotein G-2...
Biology Products: