Navigation Links
Antioxidants can protect against omega 6 damage -- or promote it
Date:4/4/2014

SAN DIEGO Given omega 6 fatty acid's reputation for promoting cancer at least in animal studies researchers are examining the role that antioxidants play in blocking the harmful effects of this culprit, found in many cooking oils. After all, antioxidants are supposed to prevent DNA damage. But employing antioxidants could backfire, say researchers at Georgetown Lombardi Comprehensive Cancer Center.

In their study, being reported at the AACR Annual Meeting 2015, researchers found that vitamin E actually increased specific damage linked to omega 6 fatty acids. The vitamin promoted the formation of an "adduct," a structure that links a chemical to DNA, and which may cause mutations.

On the other hand, in the setting of omega 6, the antioxidant green tea polyphenol reduced formation of another commonly found "adduct" from omega-6 fatty acid suggesting it may have beneficial health effects.

The third antioxidant tested, alpha-lipoic acid found in spinach and broccoli and proven to have anti-cancer properties had no effect on either of the two adducts studied.

The study was designed to understand why omega 6 polyunsaturated fatty acids promote liver cancer, while their cousin, omega 3, helps prevent cancer.

Researchers examined formation of DNA-damaging adducts in liver cells treated with omega 6. One of those adducts, ϒ-OHPdG, is well known, but the research team discovered a second one DHHedA.

"This study revealed that DHHedA is a novel type of DNA damage, found in the tissues of rodents and humans, that is caused by omega 6 polyunsaturated fatty acid," says the study's lead author, Fung-Lung Chung, PhD, a professor of oncology at Georgetown Lombardi and professor of biochemistry and molecular & cellular biology at Georgetown University Medical Center.

In rats engineered to develop liver cancer, green tea polyphenols reduced formation of ϒ-OHPdG adducts, and vitamin E increased production of DHHedA adducts.

Researchers also discovered that although alpha-lipoic acid had no effect on either adduct, rats who ate the antioxidant had a significantly longer lifespan, compared with rats treated with the other antioxidants. "The precise reason why this happened is not yet known," says Chung.

"Our findings are beginning to shed light on why omega 6 fatty acids are believed to have negative health effects," Chung says, "but we have a long way to go before we can make definitive health claims on these antioxidants."

He added, "Not all antioxidants are created equal. They all have different properties, and they play different roles in various tissues. What we find in liver cancer may not hold true for other cancers."


'/>"/>

Contact: Karen Teber
km463@georgetown.edu
Georgetown University Medical Center
Source:Eurekalert

Related biology news :

1. Dont throw out old, sprouting garlic -- it has heart-healthy antioxidants
2. Red delicious or wolf apple? Brazilian savanna fruits high in antioxidants
3. Antioxidants -- too much of a good thing?
4. Antioxidants may ease PAD blood pressure increase
5. Diet high in total antioxidants associated with lower risk of myocardial infarction in women
6. Powerful class of antioxidants may be potent Parkinsons treatment
7. Academy of Natural Sciences receives major grant for program to protect drinking water
8. Can love hormone protect against addiction?
9. Research findings link post-heart attack biological events that provide cardioprotection
10. In grasslands remade by humans, animals may protect biodiversity
11. Study pinpoints protective mutations for type 2 diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/12/2016)... WearablesResearch.com , a brand of Troubadour ... from the Q1 wave of its quarterly wearables survey. ... receptivity to a program where they would receive discounts ... company. "We were surprised to see that ... LaColla , CEO of Troubadour Research, "primarily because there ...
(Date:4/26/2016)... LONDON , April 26, 2016 ... EdgeVerve Systems, a product subsidiary of Infosys (NYSE: ... a partnership to integrate the Onegini mobile security ... (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ) The ... enhanced security to access and transact across channels. ...
(Date:4/14/2016)... , April 14, 2016 ... and Malware Detection, today announced the appointment of ... the new role. Goldwerger,s leadership appointment comes ... the heels of the deployment of its platform at ... behavioral biometric technology, which discerns unique cognitive and physiological ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... June 27, 2016  Liquid Biotech ... funding of a Sponsored Research Agreement with The ... cells (CTCs) from cancer patients.  The funding will ... levels correlate with clinical outcomes in cancer patients ... will then be employed to support the design ...
(Date:6/24/2016)... June 24, 2016 Epic Sciences unveiled ... cancers susceptible to PARP inhibitors by targeting homologous ... (CTCs). The new test has already been incorporated ... multiple cancer types. Over 230 clinical ... response pathways, including PARP, ATM, ATR, DNA-PK and ...
(Date:6/23/2016)... ... June 23, 2016 , ... Mosio, ... second eBook, “Clinical Trials Patient Recruitment and Retention Tips.” Partnering with experienced clinical ... eBook by providing practical tips, tools, and strategies for clinical researchers. , “The ...
(Date:6/23/2016)... 23, 2016 /PRNewswire/ - FACIT has announced the ... biotechnology company, Propellon Therapeutics Inc. ("Propellon" or ... of a portfolio of first-in-class WDR5 inhibitors for ... as WDR5 represent an exciting class of therapies, ... medicine for cancer patients. Substantial advances have been ...
Breaking Biology Technology: