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Antioxidants -- too much of a good thing?
Date:7/21/2013

subjects nor the investigators knew which participant that received either resveratrol or placebo.

"We found that exercise training was highly effective in improving cardiovascular health parameters, but resveratrol supplementation attenuated the positive effects of training on several parameters including blood pressure, plasma lipid concentrations and maximal oxygen uptake."

Ylva Hellsten, the leader of the project, says:"We were surprised to find that resveratrol supplementation in aged men blunts the positive effects of exercise training on cardiovascular health parameters, in part because our results contradict findings in animal studies.

"It should be noted that the quantities of resveratrol given in our research study are much higher than what could be obtained by intake of natural foods."

This research adds to the growing body of evidence questioning the positive effects of antioxidant supplementation in humans.

Michael Joyner, from The Mayo Clinic USA, says how the study has wider implications for research: "In addition to the surprising findings on exercise and resveratrol, this study shows the continuing need for mechanistic studies in humans. Too often human studies focus on large scale outcomes and clinical trials and not on understanding the basic biology of how we adapt."


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Contact: Lucy Holmes
lholmes@physoc.org
44-020-726-95727
Wiley
Source:Eurekalert

Page: 1 2

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