Navigation Links
Antioxidant overload may underlie a heritable human disease
Date:8/13/2007

Despite the popular notion that antioxidants, such as vitamins C and E, offer health-promoting benefits by protecting against damaging free radicals, a new study in the August 10 issue of the journal Cell reveals that, in fact, balance is the key. The researchers show in mice that an overload of natural antioxidants can actually lead the heart to failure.

There is plenty of evidence about the damaging effects of oxidative stress, but there is another side to the coin, said Ivor Benjamin of the University of Utah, Salt Lake City. There has been so much emphasis on free radicals to the exclusion of the potential consequences of reductants. Our study provides the first bona fide example of the role that reductive stress can play in disease.

Reductants, sometimes referred to as antioxidants, are elements or compounds that easily give up an electron to become oxidized, while oxidizing agents readily accept electrons. In the body, such oxidation-reduction (redox) reactions are integral to the release and storage of energy. Many cellular pathways are also sensitive to the prevailing redox condition.

Oxidative stress, which consumes reducing equivalents, has been often implicated in numerous cardiac and other diseases, Benjamin noted. However, the possibility remained that an inverse imbalance could provoke reductive stress, with the potential for similar deleterious effects. Indeed, reductive stress had been demonstrated in simpler organisms but not in mammals and/or disease states, he said.

In the current study, the researchers examined mice carrying a human mutation earlier linked to so-called protein aggregation skeletal myopathies and cardiomyopathies, in which weakening skeletal and heart muscle contain clumps of proteins. Although the genetic basis for the disease had been linked to mutations in one of two genes, the mechanism responsible remained mysterious.

The researchers now show that mice with one of the mutant g
'/>"/>

Contact: Erin Doonan
edoonan@cell.com
617-397-2802
Cell Press
Source:Eurekalert

Page: 1 2

Related biology news :

1. Red delicious, Northern Spy apples have most antioxidants, chemists find
2. Antioxidant selenium offers no heart-disease protection
3. Free-radical busting antioxidants might not promote healthy hearts
4. Mushrooms as good an antioxidant source as more colorful veggies
5. Antioxidant protects against lung damage in silicosis
6. Unique tomatoes tops in disease-fighting antioxidants
7. Honeydew honeys are better antioxidants than nectar honeys
8. Pistachios lower cholesterol, provide antioxidants
9. ASU research shows connection between testosterone, dietary antioxidants and bird coloration
10. Surprising findings reported about iron overload
11. Different strategies underlie the ecology of microbial invasions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... an expansion of marine protected areas is needed to ... According to investigators from the Wildlife Conservation Society and ... on saving the largest numbers of species, often at ... difficult-to-replace ecological functions. , Many vital ecological ... that also are food for millions of people. ...
(Date:8/28/2014)... to Research Careers) Program has announced the travel award ... October 18 22, 2014 in San Diego, California. ... of students, post doctorates and scientists from underrepresented groups ... to encourage the participation of young scientists at the ... conferred 16 awards totaling $29,600., The FASEB MARC Program ...
(Date:8/28/2014)... FASEB MARC (Maximizing Access to Research Careers) Program ... Genetics Society of America,s 27th Annual Mouse Molecular ... 2014 in Pacific Grove, California. These awards ... post doctorates and scientists from underrepresented groups into ... to encourage the participation of young scientists at ...
Breaking Biology News(10 mins):Study finds marine protected areas inadequate for protecting fish and ocean ecology 2
... Washington D.C. (September 22, 2008): Integrating sophisticated ... information systems and clinical expertise has the ... lowering treatment costs. This is especially true ... today said an international panel of experts, ...
... to be involved in colon cancer but the exact mechanisms ... that a molecule produced by a common gut bacterium activates ... published in the October issue of the Journal of ... can cause colon cancer. There are more bacteria in ...
... energy doesn,t always mean solar or wind power. In ... chemical and biological engineering professor James Dumesic look a ... vehicles today. That,s because the new fuels are ... The only difference is where they come from. ...
Cached Biology News:Combining advanced medical and information technologies offers pathway to lower health care costs 2Combining advanced medical and information technologies offers pathway to lower health care costs 3Cancer-causing gut bacteria exposed 2New process derives 'green gasoline' from plant sugars 2
(Date:8/29/2014)... August 29, 2014 Local veterinarian, Dr. ... Hospital are seeking candidates to participate in an investigational ... The ultimate goal of this study is to ... into one or two arthritically affected joints can help ... , Candidates for the current investigational study must be ...
(Date:8/29/2014)... A major challenge before new biotechnology ... realm of Boston-Cambridge, is gaining visibility that can lead ... the Director of Boston’s Adult Stem Cell Technology Center, ... visibility of his company an important priority since he ... to a social media marketing campaign launched ...
(Date:8/28/2014)... (PRWEB) August 28, 2014 Best Sanitizers, ... for the food processing industry, is asking industry professionals ... side comparison of the E2 soap they’re currently using ... Foam Soap . Hand hygiene is critical to ... food processing environment. Six key criteria are identified to ...
(Date:8/28/2014)... WEST LAFAYETTE, Ind. A new research ... "nanomechanical" properties of tiny structures undergoing stress ... insights to improve designs for microelectronics and ... spectroscopy, reveals information about how heating and ... their mechanical properties. Researchers have discussed the ...
Breaking Biology Technology:Burnt Hills Veterinary Hospital Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 2The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 3The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 4Best Sanitizers, Inc. Asks Food Industry Professionals: With Fall Harvest On the Way, Is Your E2 Hand Soap Up to the Task? 2New analytical technology reveals 'nanomechanical' surface traits 2New analytical technology reveals 'nanomechanical' surface traits 3
... on its recent analysis of new products within the ... the 2012 North American Frost & Sullivan Award for ... a "gold standard" polymerase chain reaction (PCR) instrument. The ... amplification, and detection, all in a multiplexed, automated, and ...
... Inc. (NYSE Amex: BONE ), a leader in ... for medical applications, today announced its financial results for the ... Fourth Quarter 2011 Highlights: Revenue ... for the fourth quarter of 2010. Operating loss decreased ...
... March 21, 2012 When deciding between the ... the upcoming and existing research programs prove highly ... introduces the Life Sciences Content: Pharmaceuticals, Biotechnology, ... to 2012 compendium.  This resource includes Frost ...
Cached Biology Technology:Frost & Sullivan Recognizes iCubate for Developing the New Gold Standard Instrument in the PCR Market 2Frost & Sullivan Recognizes iCubate for Developing the New Gold Standard Instrument in the PCR Market 3Frost & Sullivan Recognizes iCubate for Developing the New Gold Standard Instrument in the PCR Market 4Bacterin Announces Record 2011 Revenue of $30.1 Million; Up 96% Year-over-Year 2Bacterin Announces Record 2011 Revenue of $30.1 Million; Up 96% Year-over-Year 3Bacterin Announces Record 2011 Revenue of $30.1 Million; Up 96% Year-over-Year 4Bacterin Announces Record 2011 Revenue of $30.1 Million; Up 96% Year-over-Year 5Bacterin Announces Record 2011 Revenue of $30.1 Million; Up 96% Year-over-Year 6Bacterin Announces Record 2011 Revenue of $30.1 Million; Up 96% Year-over-Year 7Bacterin Announces Record 2011 Revenue of $30.1 Million; Up 96% Year-over-Year 8Bacterin Announces Record 2011 Revenue of $30.1 Million; Up 96% Year-over-Year 9Bacterin Announces Record 2011 Revenue of $30.1 Million; Up 96% Year-over-Year 10Frost & Sullivan Announces Cutting Edge Life Sciences Research on the Horizon 2Frost & Sullivan Announces Cutting Edge Life Sciences Research on the Horizon 3
mu Opioid Receptor splice variant Immunogen: Synthetic peptide corresponding to residues K S C M D R G M R N L L P D D G P R Q E of Mu Opioid Receptor. Storage: -20 C, Avoid Freeze/Thaw Cycle...
Rac1/2/3 (L129) Antibody Shipping Temperature: HOT Storage Temperature: -20C...
In plasmid or lambda vector. Please inquire for more details!...
ANTI-RAT ADHESION MARKERS, CDs, CYTOKINES, ETC Rat ICAM PE - Mouse IgG1...
Biology Products: