Date:4/10/2012

ibi, "Our data show that treatment with the iron chelator deferiprone opposes several pathological events induced by a cholesterol-enriched dietDeferiprone reduced the generation of Aβ and lowered levels of tau phosphorylation." While there was no effect on ROS levels, he comments that "It is possible that a higher dose of deferiprone, or combination therapy of deferiprone together with an antioxidant to prevent ROS generation would more-fully protect against the deleterious effects of cholesterol-enriched diet that are relevant to AD pathology."

Noted expert on metals metabolism research on AD Ashley Bush, MD, PhD, Mental Health Research Institute, Melbourne, Australia, adds that "this research highlights the role of metal ions as key modulators for the toxic interactions of risk factors for Alzheimer's disease, in this case cholesterol. Drugs targeting these metal interactions hold promise as disease-modifying agents."

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Contact: Daphne Watrin d.watrin@iospress.nl 31-206-883-355 IOS Press Source:Eurekalert

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