Navigation Links
Antioxidant may disrupt Alzheimer's disease process
Date:4/10/2012

Amsterdam, NL, April 10, 2012 Alzheimer's disease (AD) is now the sixth leading cause of death among Americans, affecting nearly 1 in 8 people over the age of 65. There is currently no treatment that alters the course of this disease. However, an increasing amount of evidence suggests that changes in the way the body handles iron and other metals like copper and zinc may start years before the onset of AD symptoms. A new study shows that reducing iron levels in blood plasma may protect the brain from changes related to AD.

In the current study a group of investigators from led by Dr. Othman Ghribi, PhD, Associate Professor, Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine and Health Sciences, rabbits were fed a high-cholesterol diet which caused them to accumulate plaques of a small protein called beta-amyloid (Aβ). These plaques are toxic to neurons and central to the development of Alzheimer's disease. The rabbits also developed changes in tau protein, which is part of the skeleton of neurons. When this protein becomes heavily phosphorylated, the ability of neurons to conduct electrical signals is disrupted. Following treatment with a drug called deferiprone (an iron chelator), the iron level in the rabbits' blood plasma was reduced and the levels of both beta-amyloid and phosphorylated tau in the brain were returned to normal levels.

Another degenerative process in AD involves the production of reactive oxygen species (ROS) that can damage neurons in the brain. Deferiprone is also thought to suppress this reactive oxygen damage caused by free iron in the bloodstream, however in this study there was no difference in reactive oxygen species in the treated group. It appears that iron in the AD brain is located in the wrong places in particular it accumulates to very high levels in the cores of beta-amyloid plaques and is very reactive in this setting.

According to Dr. Ghr
'/>"/>

Contact: Daphne Watrin
d.watrin@iospress.nl
31-206-883-355
IOS Press
Source:Eurekalert

Page: 1 2

Related biology news :

1. Antioxidant has potential in the Alzheimers fight, UGA researchers find
2. Powerful antioxidant resveratrol prevents metabolic syndrome in lab tests: U of A study
3. Antioxidant spices reduce negative effects of high-fat meal
4. Antioxidant formula prior to radiation exposure may prevent DNA injury
5. Antioxidants in pregnancy prevent obesity in animal offspring
6. Preterm mothers milk contains less antioxidants than mothers completing their gestation
7. Jefferson researchers provide genetic evidence that antioxidants can help treat cancer
8. Roasting coffee beans a dark brown produces valued antioxidants: UBC food scientists
9. Concerns about the safety of certain healthful plant-based antioxidants
10. Polyphenol antioxidants inhibit iron absorption
11. Want to slow aging? New research suggests it takes more than antioxidants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... West Orange, NJ. August 27, 2014. Using functional ... shown differential brain activation patterns between people with ... the first MS study in which brain activation ... cognitive task. The article, "Neuroimaging and cognition using ... was published online on June 11 by ...
(Date:8/27/2014)... have identified a gene that could help scientists engineer ... in the cell membrane of plants that senses changes ... machinery accordingly. , "It,s similar to a thermostat," ... Duke. , The findings, which appear Aug. 28 ... easier to feed the world,s growing population in the ...
(Date:8/27/2014)... of the HIV drug maraviroc, a new study from ... the drug was licensed in 2007, included mostly European-Americans, ... removing maraviroc from the body. The current study shows ... including nearly half of African-Americans end up with ... lack the protein even when given the same dose. ...
Breaking Biology News(10 mins):Kessler Foundation researchers publish first study of brain activation in MS using fNIRS 2Water 'thermostat' could help engineer drought-resistant crops 2Dosage of HIV drug may be ineffective for half of African-Americans 2
... one scratchy tune learned in its youth, which it ... occasionally, the finch might improvise, experimenting with a slower, ... studying the finch now say the improvisation arises from ... section of the forebrain that seems to generate the ...
... in St. Louis have discovered an entirely new cellular ... plant flowering and DNA methylation, a key chemical process ... by Craig Pikaard, Ph, D., Washington University professor of ... kind of RNA polymerase found only in plants and ...
... (CLL) is an incurable disease in which cells in the ... become abnormal and malignant (leukemic). The progression of the disease ... regarding the rate of production of CLL cells, and the ... believed that CLL was a static disease of long-lived lymphocytes ...
Cached Biology News:Bird Brains Show How Trial and Error May Contribute to Learning 2Bird Brains Show How Trial and Error May Contribute to Learning 3New RNA polymerase discovered in plants 2New RNA polymerase discovered in plants 3The very unexpected life and death of a leukemic cell 2
(Date:8/28/2014)... PARK, Calif. , Aug. 28, 2014 /PRNewswire/ ... focused on developing novel mid- to late-stage cardiovascular ... $7.0 million in its first round of financing. ... Biomedical Investments and Hercules Bioventures with participation from ... entrepreneur and pharmaceutical executive, Dr. Larry Hsu ...
(Date:8/28/2014)... Vt. (PRWEB) August 28, 2014 ... testing around the world is available from Strategic ... diagnostics companies. “ Industrial Microbiology Market Review, Fourth ... Industrial Market ” (IMMR—4) tracks and compares microbiology ... in North America, Europe and Asia, and forecasts ...
(Date:8/28/2014)... 2014 Supplementing their complete line ... for Eppendorf Safe Lock Centrifuge Tubes . ... highest quality tubes at an affordable price. Eppendorf ... doing chemical, medical, pharmaceutical, and life science research ... regularly able to afford Eppendorf products. , Eppendorf ...
(Date:8/27/2014)... Green & Grow Inc. (GGI) has ... and secured Otter Capital as a significant new partner. ... of GGI’s Agriplier™ technology, building on recent compelling field ... our first meeting, we have been impressed with Otter ... said Alan Sobba, President and CEO of GGI. “We ...
Breaking Biology Technology:Armetheon Completes $7.0 Million Series A Financing 2Armetheon Completes $7.0 Million Series A Financing 32 Billion Industrial Microbiology Tests Conducted for Product Quality and Safety Worldwide 22 Billion Industrial Microbiology Tests Conducted for Product Quality and Safety Worldwide 3Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 2Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 3Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 2Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 3
... 14 Transgenomic, Inc. (the,"Company") (OTC Bulletin Board: TBIO) ... 2007. The Company,s financial results are,presented in the tables ... reported a net profit of $0.2 million or $0.00 ... to a net loss of $0.4 million or,$0.01 per ...
... Board of Directors,meeting held today, the Directors declared ... dividend is payable on September 14, 2007 to,shareholders ... Sigma-Aldrich: Sigma-Aldrich is a leading Life Science and ... and kits,are used in scientific and genomic research, ...
... Quarter Last Year, - 17 Percent Quarter-to-Quarter Revenue Gain Evidences Start of Turnaround ... for Core Business ... - DelSite Signs Additional Agreements, IRVING, Texas, Aug. 14 Carrington,Laboratories, ... $5.6 million, compared to $6.5 million in the year ago,period. The revenue in the ...
Cached Biology Technology:Transgenomic, Inc. Reports Second Quarter 2007 Results 2Transgenomic, Inc. Reports Second Quarter 2007 Results 3Transgenomic, Inc. Reports Second Quarter 2007 Results 4Transgenomic, Inc. Reports Second Quarter 2007 Results 5Transgenomic, Inc. Reports Second Quarter 2007 Results 6Transgenomic, Inc. Reports Second Quarter 2007 Results 7Transgenomic, Inc. Reports Second Quarter 2007 Results 8Carrington Reports Second Quarter 2007 Results 2Carrington Reports Second Quarter 2007 Results 3Carrington Reports Second Quarter 2007 Results 4Carrington Reports Second Quarter 2007 Results 5Carrington Reports Second Quarter 2007 Results 6Carrington Reports Second Quarter 2007 Results 7
...
cysteine and glycine-rich protein 2,...
... Antitumour agent and DNA-topoisomersae II inhibitor (IC50 = ... C 29 H 32 O 13 ... Store at: RT ... Solubility: Soluble to 100 ...
HSPBP1 Antibody...
Biology Products: