Navigation Links
Antioxidant formula prior to radiation exposure may prevent DNA injury
Date:3/29/2011

ough many antioxidants are poorly absorbed by the body, one particular mixture was effective in protecting against the specific type of injury caused by medical imaging exams. People are 70 percent water, and X-rays collide with water molecules to produce free radicals (groups of atoms with an unpaired number of electrons that are dangerous when they react with cellular components, causing damage and even cell death) that can go on to do damage by direct ionization of DNA and other cellular targets, noted Murphy. The research team evaluated whether a special combination of antioxidants have an ability to neutralize these free radicals before they can do damage.

"Our intent was to develop an effective proprietary formula of antioxidants to be taken orally prior to exposure that can protect a patient's DNA against free radical mediated radiation injury, and we have applied to patent this formulation and a specific dose strategy," said Murphy.

The experiments measured DNA damage as a surrogate marker for DNA injury. Blood was drawn from two study volunteers in duplicate, creating four individual tests per data point. DNA strand breaks are repaired by a big protein complex that binds to the site of the damage. The researchers labeled one of the proteins with a fluorescent tag. Then, under a powerful 3-D microscope, the DNA is examined for signs of repair. The more repair that is seen, the more DNA damage must have been done by the CT scan to initiate that repair. The experiments clearly showed a reduction of DNA repair in the treatment group, which means that there was less DNA injury as a result of pre-administering the antioxidant mixture, said Murphy.

The researchers concede that this is a small study and that a lot more research needs to be done; however, these initial results point toward a positive future for this kind of treatment. The group says the next step is a clinical trial in Toronto.


'/>"/>

Contact: Ellen Acconcia
eacconcia@sirweb.org
703-460-5582
Society of Interventional Radiology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Research shows Brazilian acai berry antioxidants absorbed by human body
2. Purple tomatoes: The richness of antioxidants against tumors
3. Forget the antioxidants? McGill researchers cast doubt on role of free radicals in aging
4. Antioxidants in Midwestern black raspberries influenced by production site
5. New human study reinforces antioxidant benefits of tart cherries
6. Antioxidant controls spinal cord development
7. Antioxidants arent always good for you and can impair muscle function, study shows
8. Scientists discover influenzas Achilles heel: Antioxidants
9. Tiny particles can deliver antioxidant enzyme to injured heart cells
10. Saving the single cysteine: New antioxidant system found
11. University of Colorado study shows natural antioxidants give top barn swallows a leg on competitors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/19/2015)... , May 19, 2015  Technology is rapidly ... internally and in the cloud. Passwords and their management ... of OTP and standards-based specifications such as those developed ... outmoded use of passwords presents for BYOD, COPE, IoT, ... unified biometric identity protocol. In response ...
(Date:5/14/2015)... and Markets ( http://www.researchandmarkets.com/research/5whpxg/fingerprint ) has announced ... Smart Mobile Devices " report to their offering. ... watershed year for fingerprint sensors in smartphones and tablets, ... fingerprint sensors a raison d,etre in the mobile milieu ... must-have feature in flagship smartphones. The key ...
(Date:5/11/2015)...  Through a well-rounded UAS delegation representing private industry, government, ... showing at AUVSI,s Unmanned 2015 conference last week in ... UAS industry met with over 200 hundred people ... the UAS ecosystem. "Our message is clear ... Aerospace Rich Knoll . "If you want to fly ...
Breaking Biology News(10 mins):HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 2HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 3Global Smart Mobile Devices Fingerprint Sensors Market 2015-2019: Key Vendors are Authentec, Validity Sensors, Fingerprint Cards, Next Biometrics Group. IDEX, and Qualcomm 2Ohio Flies High at Unmanned '15, Sets Stage for Ohio UAS Conference 2
... the University of Houston for a two-day conference to discuss ... , The UH Texas Obesity Research Center (TORC) ... UH M.D. Anderson Library, Rockwell Pavilion. , "We ... that others will see the wealth of obesity research that ...
... hopeful moms-to-be learn, there are important considerations to the ... environment, regular hormonal injections and the timing of the ... procedure. Now a Tel Aviv University researcher ... look at the role that gravity and other biomechanical ...
... team of scientists led by the UK has been given ... frontiers - an ancient lake hidden deep beneath Antarctica,s ice ... the size of Lake Windermere (UK) may have been ... unique forms of life. The team hopes the exploration will ...
Cached Biology News:Texas Obesity Research Center at UH assembles researchers to discuss obesity 2Engineering bouncing babies, 1 at a time 2Final frontier: Mission to explore buried ancient Antarctic lake given green light 2
(Date:5/21/2015)... , May 21, 2015  Prima Biomed Ltd. ... that is striving to become a leader in the ... recently announced that the final CVac data from the ... a clear trend for a clinically meaningful improvement in ... second remission patients. In the group of ...
(Date:5/21/2015)... Imagine being able to probe and truly ... Being able to read faces and enjoy genuine invisible ... their thoughts and actions like never before. Use ... unique abstract paintings and video, or, play a completely ... as it creates action, dialog, and outcomes based on ...
(Date:5/21/2015)...  CytRx Corporation (NASDAQ: CYTR ), a ... today announced positive updated results from its ongoing ... treatment of unresectable glioblastoma multiforme (GBM), a deadly ... is designed to investigate the preliminary efficacy and ... progressed following prior treatment with surgery, radiation and ...
(Date:5/21/2015)... - RepliCel Life Sciences Inc. (TSX.V: RP) (OTCQB: ... on the development of autologous cell therapies, announced ... Society for Cellular Therapy (ISCT) on RepliCel,s autologous ... a Phase 1/2 clinical trial.  The presentation, taking ... PM to 7:00 PM local time, will review ...
Breaking Biology Technology:Correction Continues after Big Move - BrokerBank Securities, Inc. 25 Days to Meet ARGUS - The World's First Contactless Emotions Scanner 2CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 2CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 3CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 4CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 5CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 6CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 7RepliCel to Present Unique Autologous Cell Treatment for Achilles Tendinosis at International Society for Cellular Therapy Conference 2RepliCel to Present Unique Autologous Cell Treatment for Achilles Tendinosis at International Society for Cellular Therapy Conference 3
... Va., June 27, 2011 A Continuing Medical Education (CME) ... of key risk factors , will be hosted at the ... 2011 from 8:30am to 1pm. "Beating ... Education credits, is designed to help doctors eradicate this disease ...
... JUPITER, Fla., June 27, 2011 Dyadic International, ... company focused on the discovery, development, manufacture and ... industrial enzyme, bioenergy, and biopharmaceutical industries, announced today ... development and license agreement with a key provider ...
... PharmacoFore, Inc., a privately held biopharmaceutical company developing ... Dr. Joseph Stauffer as Chief Medical Officer & VP, ... Property. Dr. Joseph Stauffer ... Prior to joining PharmacoFore, Dr. Stauffer ...
Cached Biology Technology:Health Diagnostic Laboratory Inc. Sponsors Lecture Series in West Palm Beach, Florida 2Dyadic International Enters Into Research and License Agreement With Major Player in the Animal Feed Industry 2Dyadic International Enters Into Research and License Agreement With Major Player in the Animal Feed Industry 3PharmacoFore, Inc. Announces Appointment of Chief Medical Officer and Vice President of Intellectual Property 2PharmacoFore, Inc. Announces Appointment of Chief Medical Officer and Vice President of Intellectual Property 3PharmacoFore, Inc. Announces Appointment of Chief Medical Officer and Vice President of Intellectual Property 4
... The European Collection of Cell Cultures (ECACC) ... West of the West of England, Bristol, ... the quality control of HER2, oestrogen and ... paraffin wax sections of formalin fixed, breast ...
... Electro-4 design allows "4 gels in one ... possible to run 200,samples or more in ... to four,horizontal gels. To ensure even migration, ... number of gels being run. Ideal for,high ...
Porcine Pulmonary Artery Endothelial Cells (PPAEC) (>500,000 cells)...
... several isoprostanes produced from arachidonic acid during lipid ... the rat. 8-iso PGE2 inhibits U-46619 or I-BOP-induced ... 5 µM, respectively. When infused into the renal ... 4 mg/kg/min, 8-iso PGE2 decreases the GFR and ...
Biology Products: