Navigation Links
Antioxidant controls spinal cord development
Date:9/18/2009

Researchers at the Johns Hopkins School of Medicine have discovered how one antioxidant protein controls the activity of another protein, critical for the development of spinal cord neurons. The research, publishing this week in Cell, describes a never-before known mechanism of protein control.

"This is the first time we've seen this type of chemical reaction control neuronal differentiation," says Shanthini Sockanathan, Ph.D., an associate professor at the Johns Hopkins Solomon H. Snyder Department of Neuroscience. "And it's probably not specific for motor neurons that we study, but also for development of a wide variety of neurons."

Previous research had shown that the GDE2 protein can cause immature cells in the spinal cord to differentiate into motor neurons, the nerve cells that connect to and control muscle contraction. Too little GDE2 causes motor neurons to not develop, while too much GDE2 causes them to develop too quickly, depleting progenitor pools.

"We reasoned that there must be tight control of GDE2 so we set out to look for the regulator by looking for other proteins that can bind to GDE2," says Sockanathan.

Using biochemical approaches to isolate all proteins that normally bind to GDE2 in the developing spinal cord, followed by proteomic analysis to identify all binding proteins, the research team found a few hundred proteins. One, Prdx1, had been reported by others to have tumor-suppressing abilities, which caught Sockanathan's eye for further investigation.

The team first asked if the Prdx1 protein can affect motor neuron development by removing it from developing spinal cords of chick embryos. Embryos lacking Prdx1 showed loss of motor neurons similar to that seen in embryos lacking GDE2, suggesting that indeed Prdx1 is somehow involved in motor neuron development.

To figure out how Prdx1 and GDE2 interact to cause immature cells to develop into motor neurons, the team mutated the
'/>"/>

Contact: Audrey Huang
audrey@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

Related biology news :

1. Antioxidant overload may underlie a heritable human disease
2. Clemson chemists discover new way antioxidants fight debilitating diseases
3. Antioxidant to retard wrinkles discovered by Hebrew University researcher
4. Antioxidants could provide all-purpose radiation protection
5. Mounting evidence shows red wine antioxidant kills cancer
6. Antioxidant users dont live longer, analysis of studies concludes
7. Research shows Brazilian acai berry antioxidants absorbed by human body
8. Purple tomatoes: The richness of antioxidants against tumors
9. Forget the antioxidants? McGill researchers cast doubt on role of free radicals in aging
10. Antioxidants in Midwestern black raspberries influenced by production site
11. New human study reinforces antioxidant benefits of tart cherries
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... on average over a 35 year period in which ... impact of humans on declining animal numbers. This decline ... insects, spiders, crustaceans, slugs and worms bring to our ... decomposition for nutrient cycling, water filtration and human health. ... led by UCL, Stanford and UCSB, focused on the ...
(Date:7/24/2014)... A new study has identified two factors that ... increase the production of highly qualified physics teachers. ... to champion physics teacher education in combination with ... initiatives remain viable. Science, Technology, Engineering and Math ... and the study points the way for institutions ...
(Date:7/24/2014)... biodiversity, the product of 3.5 billion years of evolutionary ... of life. But it may be reaching a tipping ... and analysis of data published in Science , ... and decline of animals is contributing to what appears ... mass biological extinction event. , Since 1500, more than ...
Breaking Biology News(10 mins):Invertebrate numbers nearly halve as human population doubles 2Invertebrate numbers nearly halve as human population doubles 3Creating sustainable STEM teacher preparation programs 2Stanford biologist warns of early stages of Earth's 6th mass extinction event 2Stanford biologist warns of early stages of Earth's 6th mass extinction event 3
... German . The fingers on the outside ... than the middle finger, which is exposed to the "cross fire" ... handicap can be compensated. The working group led by PD Dr. ... report in the current issue of PNAS. Thumb and ...
... you really eating when you,re eating chicken? Do different types ... have similar fingerprints? How does sleep affect your memory? Does ... 33 local schools will answer these and other intriguing questions ... University of California, Riverside, Feb. 7-9. The fair will take ...
... of all took a long time to kill 90 percent ... newly published report. It shows that mass extinctions need ... the University of Cincinnati, and 13 colleagues have produced a ... on Ellesmere Island in the Canadian Arctic. Their analysis, ...
Cached Biology News:Why the middle finger has such a slow connection 2Why the middle finger has such a slow connection 3Fair to bring future scientists and engineers to UC Riverside 2Global extinction: Gradual doom as bad as abrupt 2Global extinction: Gradual doom as bad as abrupt 3
(Date:7/24/2014)... , July 24, 2014  ECC West Africa, ... Colorado with University College Hospital (UCH) Ibadan ... development project to finance, design, construct, and operate and ... Nigeria . Under the first of the ... scoping documents and funding applications. UCH Ibadan intends to ...
(Date:7/24/2014)... synthetic processes prefer to settle into equilibriuma state ... within the realm of non-equilibrium conditions where new ... energy and phases, such as temperature fluctuations, freezing ... to regulate their body temperature, airplanes to fly, ... , But even though these conditions exist ...
(Date:7/24/2014)... , July 24, 2014  CorMedix Inc. (NYSE ... and commercializing therapeutic products for the prevention and ... receipt of notice on July 18, 2014 from ... has accepted the CorMedix plan to regain compliance ... a result, the NYSE-MKT is continuing the Company,s ...
(Date:7/24/2014)... 2014 1000 balances – 4 steps ... customers’ weighing needs and expertly narrows down the mass ... scales or even terminals. , First, select the ... (or select readability instead) and define the accuracy – ... criteria narrows down the list to models that fit ...
Breaking Biology Technology:ECC Signs a Contract for the Finance, Design, and Construction of a Premier Cancer Institute in Ibadan, Nigeria 2New approach to form non-equilibrium structures 2CorMedix, Inc. Granted Extension of NYSE-MKT Listing 2CorMedix, Inc. Granted Extension of NYSE-MKT Listing 3
... GENR ) today announced its financial results for ... net loss for,the three-month period ended September 30, 2007, ... as compared to a net loss of $4.5,million, or ... period,ended September 30, 2006. The net loss for the ...
... 9 Iomai Corporation,(Nasdaq: IOMI ) today announced ... the markets open and hold a conference call and,live ... Nov.,13, 2007 at 11 a.m. Eastern Time. Conference ... on Tuesday, Nov. 13 at 11 a.m.,Eastern Time via ...
... announced that it will conduct a,conference call and audio web cast on Tuesday, ... of its financial,results for the third quarter ended September 30, 2007. Lev anticipates,releasing ... November ... 1PM ET DIAL IN #: ...
Cached Biology Technology:Genaera Corporation Announces Third Quarter Financial Results 2Genaera Corporation Announces Third Quarter Financial Results 3Genaera Corporation Announces Third Quarter Financial Results 4Genaera Corporation Announces Third Quarter Financial Results 5Iomai to Announce Third Quarter 2007 Financial Results and Host Webcast on Tuesday, November 13 2Lev Pharmaceuticals Invites You to Participate in its Q3'07 Earnings Results Conference Call and Webcast 2
... for interferons are cytopathic effect inhibition assays, ... The neutralization assay measures the antibody's ... the cytokine. Sample types include; tissue culture ... these assays, one unit is defined as ...
... Yeast nitrogen base (YNB) is a base medium ... media. YNB contains ammonium sulfate but does not ... pouches are available. Each pouch contains reagents ... Pichia media or 1000 ml of 10X YNB ...
... ALDEFLUOR Stem Cell Identification ... comprises a substrate for ... (ALDH) that is highly ... stem cells, making ALDH ...
... MetaVue Imaging System is the cost-effective solution ... commands tailored to common research imaging tasks, ... analysis and simple image analysis. Compatibility ... library means that MetaVue has the power ...
Biology Products: