Navigation Links
Antimicrobial sutures reduce infections in brain shunt surgery, study finds
Date:7/25/2008

BUFFALO, N.Y. -- Children born with hydrocephalus, or "water on the brain" must have shunts implanted to drain the fluid away from the brain to reduce harmful pressure.

While shunts do their job well, the rate of shunt infection in children is very high for a variety of reasons, which requires putting the child through another surgery to replace the shunt, bringing with it more hospital time, potential additional neurological complications and an increased risk of death.

Now a new trial conducted by faculty at the University at Buffalo has shown that using antimicrobial sutures to secure the shunt and close the wound significantly reduces the number of shunt infections arising during the first six months after surgery.

Results of the trial appear online in the Journal of Neurosurgery: Pediatrics and will be published in the August issue of the journal.

Sixty-one children requiring shunt surgery were assigned randomly to undergo their surgery with antimicrobial sutures, considered the study group, or with usual sutures, which served as the control group. A total of 84 shunt procedures were performed over 21 months. All procedures were performed by one of two pediatric neurosurgeons at Women & Children's Hospital of Kaleida Health in Buffalo.

At the trial's end, the shunt infection rate in the study group was 4.3 percent (2 of 46 procedures), compared to 21 percent (8 of 38 procedures) in the control group.

"Many techniques and devices have been investigated to reduce shunt infection rates," said Curtis J. Rozzelle, M.D., assistant professor of neurosurgery in UB's School of Medicine and Biomedical Sciences and first author on the paper. He also is surgical director of the Comprehensive Epilepsy Program at Women & Children's Hospital. "Some studies, but not all, found that antibiotic-impregnated shunt systems in particular appear to reduce infection risk," noted Rozzelle. "Unfortunately, none of these studies were prospective, randomized and double-blinded.

"In animal trials sutures coated with the antimicrobial triclosan have been shown to reduce the number of bacteria adhering to sutures, but only one study has been published to date on their effect in preventing surgical site infection, so we decided to conduct our own trial," he said.

"Our results showed that using antimicrobial sutures reduced infection risk by 16 percent."

Antibiotic-impregnated shunts, which are used in some surgeries, have several limitations, said Rozzelle: "They don't provide complete protection, they can't be used in patients who are allergic to the antibiotics and they are a lot more expensive than non-impregnated shunts."

"Closing wounds with antimicrobial sutures may reduce infections in procedures implanting other devices, such as pacemakers and neurostimulators, pumps that deliver pharmaceuticals and shunts elsewhere in the body," he said.

Rozzelle and colleagues are planning to conduct a larger randomized controlled trial to confirm their initial findings.


'/>"/>

Contact: Lois Baker
ljbaker@buffalo.edu
716-645-5000 x1417
University at Buffalo
Source:Eurekalert

Related biology news :

1. Scientists decipher mechanism behind antimicrobial hole punchers
2. Cystic fibrosis patients may breathe easier, thanks to bioengineered antimicrobials
3. Fireproofing homes dramatically reduces forest fire size, according to new study
4. Green skies: Engineers work may reduce jet travels role in global warming
5. Women more depressed and men more impulsive with reduced serotonin functioning
6. Toll charges reduce travel time
7. Naturally-occurring apple compounds reduce risk of pancreatic cancer
8. Expecting an afternoon nap can reduce blood pressure
9. Clinical studies show REMICADE reduces incidence of bowel surgeries in ulcerative colitis patients
10. Exercise improves thinking, reduces diabetes risk in overweight children
11. Zinc may reduce pneumonia risk in nursing home elderly
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/9/2016)... 2016 Vigilant Solutions announces today that an agency ... develop a lead in a difficult homicide case. The agency ... locate the suspect vehicle. Due to the ongoing investigation, the ... omitted at the agency,s request. --> ... victim was found deceased at an intersection here in the ...
(Date:2/5/2016)... 5, 2016 http://www.researchandmarkets.com/research/5kvw8m/global_facial ... "Global Facial Recognition Market 2016-2020" ... http://www.researchandmarkets.com/research/5kvw8m/global_facial ) has announced the addition of ... report to their offering. --> ... has announced the addition of the ...
(Date:2/3/2016)... GOTHENBURG, Sweden , February 4, 2016 ... Revenues amounted to SEK 1,351.5 M (105.0), up 1,187% compared with fourth ... Operating profit amounted to SEK 517.6 M (loss: 30.0). Earnings ... from operating activities was SEK 537.4 M (neg: 74.7). , ... , Revenues amounted to SEK 2,900.5 M (233.6), up 1,142% ...
Breaking Biology News(10 mins):
(Date:2/8/2016)... for the development of future natural products for crop protection. ... development center in Israel and invests ... has a variety of products adapted to regional ... more than 35 counties worldwide. ... Timorex Gold ® is used to control a broad ...
(Date:2/6/2016)... ... 06, 2016 , ... The Center for Excellence in Education (CEE) will sponsor ... on Wednesday February 10, 2016. This Bite of Science session, hosted by the ... at 1500 Remount Road in Front Royal, VA from 5:00 p.m. to 8:00 p.m. ...
(Date:2/5/2016)... , Feb. 5, 2016  In the pharmaceutical ... for a host of launch activities including the identification ... this launch activity is especially high in the oncology ... Best Practices and the Role of Medical Affairs ... companies focused on oncology therapies find better ways to ...
(Date:2/5/2016)... 5, 2016 Australian-US drug discovery and development company, ... appointment of a new Chairman, Mr John O,Connor , ... immediately. James Garner , has also been ... former Acting CEO, Mr Iain Ross , will resume ... --> James Garner , has also been formally appointed ...
Breaking Biology Technology: