Navigation Links
Antiepileptic drug use while pregnant impacts early child development
Date:7/17/2013

Children whose mothers took antiepileptic drugs (AEDs) while pregnant are at increased risk of early development issues, according to a new study published in Epilepsia, a journal published by Wiley on behalf of the International League Against Epilepsy (ILAE). Results of the study suggest that children exposed to AEDs in the womb were at risk for difficulties with motor development, language skills, social skills, and autistic traits compared to children whose mothers did not take anti-seizure medications.

Medical evidence suggests that epilepsy is fairly common in women of childbearing years, with the use of AEDs during pregnancy ranging from 0.2% to 0.5%. Studies have shown that children whose mothers have epilepsy are at increased risk of birth defects (congenital malformations)mainly thought to be caused by use of older generation AEDs during pregnancy. However, there is less understanding of AED effects on cognition during development, and there is a need for more evidence regarding long-term outcomes of children exposed to anti-seizure medication in utero.

A research team, led by Dr. Gyri Veiby from Haukeland University Hospital in Bergen, Norway, studied children from the Norwegian Mother and Child Cohort Study. From 1999 through 2008, researchers recruited mothers at 13-17 weeks of pregnancy; those mothers subsequently reported motor development, language skills, social skills and autistic traits of their children at 18 months (61,351 children) and 36 months (44,147 children). Risk of adverse outcomes was determined in children according to epilepsy in the mother or father, and with or without AED exposure in the womb.

Results show that 333 children were exposed to AEDs in the womb. At 18 months of age, the children exposed to AEDs in utero had increased risk of abnormal gross motor skills and autistic traits. Analysis of AED-exposed children at 36 months revealed an increase of abnormal scores for gross motor skills, sentence skills, and autistic traits compared to unexposed children.

Further analysis determined that AED-exposed children had increased risk of birth defects compared to children not exposed to the drugs in utero. Importantly, no increased risk of developmental delays was found in children born to women with epilepsy who did not use AED during pregnancy; children of fathers with epilepsy generally scored within the normal ranges for early childhood development.

"Our studya unique large-scale, population-based study on early developmental outcomes in offspring of parents with epilepsyconfirms that children exposed to anti-seizure medications in the womb had lower scores for key developmental areas than children not exposed to AEDs," concludes Dr. Veiby. "Exposure to valproate, lamotrigine, carbamazepine or multiple anti-seizure medications was linked to adverse developmental outcomes."

The authors stress the importance of optimal seizure control during pregnancy that balances possible adverse effects on the baby's brain development. They suggest future research examine the effects of specific AEDs on fetal development, and whether these effects continue from early childhood into school-age and adulthood.


'/>"/>

Contact: Dawn Peters
sciencenewsroom@wiley.com
781-388-8408
Wiley
Source:Eurekalert

Related biology news :

1. Eating junk food while pregnant may make your child a junk food addict
2. Libertarian paternalism and school lunches: Guiding healthier behavior while preserving choices
3. Protein filmed while unfolding at atomic resolution
4. Music with dinner: Whales sing during foraging season, not just while breeding
5. Multi-tasking whales sing while feeding, not just breeding
6. New process doubles production of alternative fuel while slashing costs
7. Ultrasound idea: Prototype NIST/CU bioreactor evaluates engineered tissue while creating it
8. Pregnant women with high celiac disease antibodies are at risk for low birth weight babies
9. Study reveals risk factors for blood clots in pregnant and postnatal women
10. Progesterone may be why pregnant women are more vulnerable to certain infections
11. Few pregnant women treated for sexually transmitted infections
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/3/2016)... 2016 --> ... "Automated Fingerprint Identification System Market by Component (Hardware and ... & Finance, Government, Healthcare, and Transportation) and Geography - ... is expected to be worth USD 8.49 Billion by ... and 2020. The transformation and technology evolution from the ...
(Date:2/2/2016)... 2016 Checkpoint Inhibitors for Cancer – ... Are you interested in the future of cancer ... inhibitors. Visiongain,s report gives those predictions to 2026 ... level. Avoid falling behind in data or ... revenues those emerging cancer therapies can achieve. There ...
(Date:2/1/2016)... 2016  Today, the first day of American Heart ... develop a first of its kind workplace health solution ... In the first application of Watson ... ), and Welltok will create a new offering that ... analytics, delivered on Welltok,s health optimization platform. The effort ...
Breaking Biology News(10 mins):
(Date:2/8/2016)... 2016  NanoViricides, Inc. (NYSE MKT: NNVC) (the "Company"), a nanomedicine ... , MD, MPH, will present information about the company,s programs at ... New York City . --> ... Room at 5:30PM EST. Registered attendees can request a one on ... . --> New York City ...
(Date:2/8/2016)... February 8, 2016 ... or the "Company"), the ultra-rapid Point-Of-Care (POC) molecular diagnostics company, ... its Chlamydia trachomatis (CT) test to be launched on the ... Directive (98/79/EC), the CT test is now cleared for sale ... --> The launch of the io® CT test signals ...
(Date:2/5/2016)... ATCC, the premier global biological materials resource ... and life science researchers that are working to address ... CDC website . --> CDC ... a single-stranded RNA virus of the Flaviviridae family, genus ... Chikungunya Viruses. Zika virus is transmitted to humans primarily ...
(Date:2/5/2016)... FRANCISCO , February 5, 2016 ... a biotechnology company focused on developing products for ... has requested Rare Pediatric Disease Designation (RPDD) from the ... pigmentosa (RP) with MANF. MANF was previously granted orphan ... 2014. --> Amarantus BioScience Holdings, Inc. ...
Breaking Biology Technology: