Navigation Links
Antidote can deactivate new form of heparin
Date:2/26/2014

Low-molecular-weight heparin is commonly used in surgeries to prevent dangerous blood clots. But when patients experience the other extreme uncontrolled bleeding in response to low-molecular-weight heparin, there is no antidote.

Now researchers at the University of North Carolina at Chapel Hill and Rensselaer Polytechnic Institute have created a synthetic form of low-molecular-weight heparin that can be reversed if things go wrong and would be safer for patients with poor kidney function.

"When doctors talk to me about the kind of heparin they want to use during and after surgery, they want it reversible, and they want it to not go through the kidneys," said Jian Liu, the John A. and Deborah S. McNeill Jr. Distinguished Professor in the UNC Eshelman School of Pharmacy, and one of the inventors of the new drug.

While unfractionated heparin is the type commonly used in procedures such as dialysis, the more-refined low-molecular-weight heparins are the drugs of choice for preventing dangerous blood clots in hospitalized patients. However, low-molecular-weight heparin doesn't have an antidote and it is also cleared from the body by the kidneys, which can make it unsuitable for patients with a weakened kidney function, a relatively common condition among hospitalized patients.

Liu and RPI's Robert Lindhardt and their teams created a synthetic version of low-molecular-weight heparin that can be counteracted by an existing drug and can be cleared by the liver, not the kidneys. Their creation is described in Nature Chemical Biology this week.

Up to 5 percent of patients receiving heparin experience some form of uncontrolled bleeding, explained Liu. Patients receiving unfractionated heparin are in less danger because there is an existing FDA-approved antidote available. The antidote, called protamine, is not as effective in reversing low-molecular-weight heparin so Liu and Lindhardt tweaked the drug's molecular struc
'/>"/>

Contact: Thania Benios
thania_benios@unc.edu
919-962-8596
University of North Carolina at Chapel Hill
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scripps Research Institute scientists develop antidote for cocaine overdose
2. Zebrafish study suggests that vitamin B2 (riboflavin) is an antidote to cyanide poisoning
3. Heparin-like compounds inhibit breast cancer metastasis to bone
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/10/2014)... 9, 2014     ...   Jifflenow, a ... solutions for business-to-business (B2B) events, today announced a ... mobile near-field communication (NFC), Bluetooth low energy (BLE), ... http://photos.prnewswire.com/prnh/20140612/691055) , Jifflenow will integrate its ...
(Date:12/4/2014)... GARDENS, Fla. , Dec. 3, 2014 /PRNewswire/ ... solutions, today announced that its DigitalPersona ® ... fingerprint readers have been deployed throughout First Bank ... , South Carolina and ... in Southern Pines, North Carolina ...
(Date:11/21/2014)... , November 18, 2014 According ... Market by Systems (Video, RFID, Access Control, Intrusion Detection, ... Hotels, Banks, Government), Component Service Geography - Global Forecasts ... Market is projected to be around $25 Billion in ... 2020, growing at a CAGR of 8.69%. ...
Breaking Biology News(10 mins):Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 2Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 3First Bank Partners with Crossmatch to Increase Log In Security 2First Bank Partners with Crossmatch to Increase Log In Security 3Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3
... professor of medicine at National Jewish Health, has ... lipids and related compounds that can inhibit inflammation ... by influenza and respiratory syncytial virus (RSV). Over ... several scientific papers describing a naturally occurring lipid ...
... bunch of inanimate chemical compounds, the nucleic and amino acids ... have put on quite a soap opera for biologists since ... A new study, a highlight in the March issue of ... In TV listings the series would be described this ...
... considered to be the principle vectors of West Nile virus ... summer. In addition, these mosquitoes may also serve as overwintering ... mosquito to egg, then larva, and then adult. To ... in mosquitoes in the field and in the lab, and ...
Cached Biology News:Does the villainous 'selfish' gene undermine genome's police? 2Does the villainous 'selfish' gene undermine genome's police? 3West Nile virus passes from female to eggs, but less so from larvae to adults 2
(Date:12/19/2014)... DUBLIN , Dec. 19, 2014 Research ... announced the addition of the "Technology Innovations ... their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... Innovations in Smart Fabrics" offers a detailed assessment ... Key Findings: 1. ...
(Date:12/19/2014)... 18, 2014 Today, TiFiber, ... pilot production facility and future company headquarters in ... innovative new materials that safely and effectively control ... because of its historic, strong support for manufacturing, ... attract leading edge, technology-based companies such as TiFiber. ...
(Date:12/19/2014)... 18, 2014 Ed Bilsky, Ph.D., vice ... Center for Excellence in the Neurosciences (CEN), and professor ... been selected as a member of the prestigious Dana ... neuroscientist from Maine to receive this honor. , ... entirely by the Dana Foundation. Its mission is ...
(Date:12/19/2014)... December 18, 2014 iLab Solutions, the ... appointment of Siri Bryant as the new Director of ... of Core Implementations. These two new leadership positions were ... service by ensuring that iLab continues to meet the ... last four years, iLab has been deployed at over ...
Breaking Biology Technology:Technology Innovations in Smart Fabrics (Technical Insights) 2Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 2Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 3Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 4UNE's Ed Bilsky Named Member of Dana Alliance for Brain Initiatives 2UNE's Ed Bilsky Named Member of Dana Alliance for Brain Initiatives 3iLab Solutions Announces Two New Leadership Positions to Meet the Needs of Its Growing Customer Base 2
... CAMBRIDGE, Mass., Dec. 17 Genzyme Corp.,(Nasdaq: ... and Drug Administration,(FDA) has approved a supplemental indication ... in combination with radioiodine to ablate,or destroy, the ... their,cancerous thyroids removed. Remnant ablation is a procedure ...
... GENEVA, Switzerland, Dec. 17 /PRNewswire-FirstCall/ - Anavex Life,Sciences ... of,Dr. Cameron Durrant to its Board of Directors. ... Global Strategic Marketing at Johnson,& Johnson (NYSE: ... privileged to welcome Dr. Durrant to our,Board," said ...
... England, December 17 , - New Deal ... its,Therapeutic Antibody Pipeline, Oxford Genome Sciences (UK) ... a strategic collaboration with Amgen to discover, develop ... cancer.,This new collaboration will enable OGeS to further ...
Cached Biology Technology:Genzyme Announces FDA Approval of Thyrogen(R) for Use in Thyroid Cancer Ablation 2Genzyme Announces FDA Approval of Thyrogen(R) for Use in Thyroid Cancer Ablation 3Genzyme Announces FDA Approval of Thyrogen(R) for Use in Thyroid Cancer Ablation 4Anavex strengthens Board of Directors 2Anavex strengthens Board of Directors 3Oxford Genome Sciences and Amgen to Jointly Discover Novel Therapeutic Antibodies in Cancer 2Oxford Genome Sciences and Amgen to Jointly Discover Novel Therapeutic Antibodies in Cancer 3
The imaging screen-K (Kodak), is a 35 x 43 cm storage phosphor screen that is used for the quantitation and imaging of 32P, 33P, 35S, 14C, and 3H....
The external laser upgrade for the Molecular Imager FX adds a 635 nm external laser; the 555 nm long pass filter is replaced with a 605 nm band pass filter to distinguish Cy5 from 532 nm excitable dy...
The HQ505, 20 OptiGreen filter for the Molecular Imager FX is a band pass filter used for detection of Cy2 and FITC with 532 nm excitation....
The filter 605DF50 for the Molecular Imager FX is a band pass filter for ethidium bromide, SYPRO Red, SYPRO Ruby, Alexa Fluor 532 and 546, and Cy3 dyes when using the 635 nm laser....
Biology Products: