Navigation Links
Antidepressants need new nerve cells to be effective, UT Southwestern researchers find
Date:8/27/2008

DALLAS Aug. 28, 2008 Researchers at UT Southwestern Medical Center have discovered in mice that the brain must create new nerve cells for either exercise or antidepressants to reduce depression-like behavior.

In addition, the researchers found that antidepressants and exercise use the same biochemical pathway to exert their effects.

These results might help explain some unknown mechanisms of antidepressants and provide a new direction for developing drugs to treat depression, said Dr. Luis Parada, chairman of developmental biology and senior author of a study in the Aug. 14 issue of the journal Neuron.

In animals, it was already known that long-term treatment with antidepressants causes new nerve cells to be generated in a part of the brain called the dentate gyrus. Exercise, which can also relieve the symptoms of depression, stimulates the generation of new nerve cells in the same area.

"We would never claim that what we study in mice directly relates to how antidepressants work in humans, but there are interesting features in parallel," Dr. Parada said. "The study unifies different observations that point to the brain's dentate gyrus region and to creation of nerve cells as being important in depression."

Antidepressants act very quickly to increase levels of natural compounds, called neurotransmitters, which nerve cells use to communicate. It takes several weeks to several months, however, for the patients who respond to such treatments to feel less depressed. Dr. Parada said this implies that some other long-term mechanism is also at work.

The current study was designed to test several phenomena that have long been observed in animal studies but have not been studied together to see if they are linked, Dr. Parada said.

The researchers focused on a molecule called TrkB, or Track-B, which is found on the surface of nerve cells and responds to several growth factors to cause ne
'/>"/>

Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

Page: 1 2

Related biology news :

1. N.Y. research team discovers how antidepressants and cocaine interact with brain cell targets
2. Compound that helps rice grow reduces nerve, vascular damage from diabetes
3. UT Southwestern researchers create molecule that nudges nerve stem cells to mature
4. Engineer develops detergent to promote peripheral nerve healing
5. Tumor-targeting viral therapy slows neuroblastoma, malignant peripheral nerve sheath tumors
6. Salk scientists identify key nerve navigation pathway
7. Team of scientists develops non-invasive method to track nerve-cell development in live human brain
8. West Nile virus spread through nerve cells linked to serious complication
9. Targeting nerve growth factor may cure liver cancer
10. Specific brain protein required for nerve cell connections to form and function
11. Senescence in liver cells is found by CSHL scientists to help limit acute tissue damage
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Antidepressants need new nerve cells to be effective, UT Southwestern researchers find
(Date:3/10/2015)...  Continuing its 167-year history of offering the Best, ... The Eye Scanning Password Authenticator , a device that ... websites or sensitive data. Employing the same ... the device has a small camera that scans and ... converting them into an encrypted ID that cannot be ...
(Date:3/10/2015)... 2015  NXT-ID, Inc. (NASDAQ: NXTD ... biometric authentication company focused on the growing mobile ... has been named the "Number One Best Tech ... Rethink Modern ( http://www.rethinkmodern.com/ ) is a web ... and lifestyle that have a unique function or design.  ...
(Date:3/3/2015)... LAKE FOREST, Calif. , March 3, ... ("Company"), the leading provider of advanced cryogenic ... serving markets including immunotherapies, stem cells, cell ... health, and reproductive medicine, today announced the ... Hutchinson Cancer Research Centers, ("Fred Hutch") ...
Breaking Biology News(10 mins):Hammacher Schlemmer Introduces The Eye Scanning Password Authenticator 2NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 2NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 3NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 4Cryoport, Inc. Expands Support of Fred Hutchinson Cancer Research Center's Clinical Research Division 2Cryoport, Inc. Expands Support of Fred Hutchinson Cancer Research Center's Clinical Research Division 3
, This press release is available in spanish . Testing Testing Testing Testing Testing Testing Testing Testing Testing Testing Testing Testing Testing Testing, ,...
... Humans are conducting massive experiments on ecosystems around ... species, boosting nutrient concentrations, and altering climates. On ... give the Jane Block Distinguished Lecture in Conservation Biology ... will discuss how our ability to assess these impacts ...
... Department,s National Renewable Energy Laboratory (NREL) recently recognized ... the past year during its Intellectual Property & ... active licenses covering the spectrum of renewable energy ... research and development agreements with industry partners, the ...
Cached Biology News:Public lecture at UC Riverside to discuss challenges in assessing human impact on ecosystems 2NREL staff recognized for breakthrough technologies 2
(Date:3/25/2015)... 2015 Having added two International locations ... of 2014, ITRA Global proudly announced recently the organization’s ... Representative Alliance, based in the United States, is one ... occupiers of commercial real estate. , Saltwood International ... Poland that exclusively advises occupiers of office space, ensuring ...
(Date:3/25/2015)... and the HAGUE, Netherlands , March ... of LES Stimulation therapy for chronic gastro-esophageal reflux disease ... Surgery [ Surgery . 2015; 157(3):556-567 ], ... minimally-invasive therapy. The study included 25 ... 11 years and taking prescribed daily proton pump inhibitor ...
(Date:3/25/2015)... 2015 /CNW/ - The Gairdner Foundation is pleased ... Awards, recognizing some of the most significant medical ... Among the world,s most esteemed medical research prizes, ... provide a $100,000 (CDN) prize to each scientist for their ... research and innovation across the country, inspiring the ...
(Date:3/25/2015)... FDNA®, the pioneer in computer-aided ... Face2Gene, allowing geneticists around the globe to access ... mobile devices. Face2Gene® facilitates detection of facial dysmorphic features ... and up-to-date genetic references. The date of the release ... in Salt Lake City, UT , ...
Breaking Biology Technology:International Organization Expands its Global Reach to Warsaw, Poland 2EndoStim LES Stimulation therapy demonstrates long term safety and efficacy results in treating reflux patients 2EndoStim LES Stimulation therapy demonstrates long term safety and efficacy results in treating reflux patients 32015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 22015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 32015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 42015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 52015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 62015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 72015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 8FDNA Releases a Multi-Platform Version of Face2Gene, a Genetic Search and Reference Solution at ACMG 2015 2
... The Madison-area technology business community has received a ... associate vice chancellor with the University of California at ... not with its resources or industry, but with cultural ... California, billions of dollars have been invested over the ...
... writing my book, I found it helpful to attend ... entrepreneurs, venture capitalists, and corporate lawyers. In my experience, ... piece of the entrepreneurial puzzle, and gave me insights ... following list of seminars, classes, and financial services organizations ...
... trade mission to Japan is building interest in possible ... experiences abroad in a conference call Monday morning. , ... several Wisconsin representatives, Doyle has been speaking at biotechnology ... spent much of today telling people about the value ...
Cached Biology Technology:San Diego success stories become a challenge for the Midwest 2San Diego success stories become a challenge for the Midwest 3San Diego success stories become a challenge for the Midwest 4Starting a high-tech company? Here uFFFDs help 2Starting a high-tech company? Here uFFFDs help 3Starting a high-tech company? Here uFFFDs help 4Starting a high-tech company? Here uFFFDs help 5Doyle builds bridges and hopes for deals in Japan 2Doyle builds bridges and hopes for deals in Japan 3
... Clone/PAD: 3B8A10. Immunogen: ... the C-terminal region of ... Specific for the human ... Human (positive control: 293 ...
...
...
... The versatile Zymo-Spin I-96 Plate can be ... manifolds for the large-scale (i.e., 96-well) purification ... polypropylene construction and unique silica-based matrix make ... g DNA or RNA in = 10 ...
Biology Products: