Navigation Links
Antidepressants need new nerve cells to be effective, UT Southwestern researchers find
Date:8/27/2008

DALLAS Aug. 28, 2008 Researchers at UT Southwestern Medical Center have discovered in mice that the brain must create new nerve cells for either exercise or antidepressants to reduce depression-like behavior.

In addition, the researchers found that antidepressants and exercise use the same biochemical pathway to exert their effects.

These results might help explain some unknown mechanisms of antidepressants and provide a new direction for developing drugs to treat depression, said Dr. Luis Parada, chairman of developmental biology and senior author of a study in the Aug. 14 issue of the journal Neuron.

In animals, it was already known that long-term treatment with antidepressants causes new nerve cells to be generated in a part of the brain called the dentate gyrus. Exercise, which can also relieve the symptoms of depression, stimulates the generation of new nerve cells in the same area.

"We would never claim that what we study in mice directly relates to how antidepressants work in humans, but there are interesting features in parallel," Dr. Parada said. "The study unifies different observations that point to the brain's dentate gyrus region and to creation of nerve cells as being important in depression."

Antidepressants act very quickly to increase levels of natural compounds, called neurotransmitters, which nerve cells use to communicate. It takes several weeks to several months, however, for the patients who respond to such treatments to feel less depressed. Dr. Parada said this implies that some other long-term mechanism is also at work.

The current study was designed to test several phenomena that have long been observed in animal studies but have not been studied together to see if they are linked, Dr. Parada said.

The researchers focused on a molecule called TrkB, or Track-B, which is found on the surface of nerve cells and responds to several growth factors to cause ne
'/>"/>

Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

Page: 1 2

Related biology news :

1. N.Y. research team discovers how antidepressants and cocaine interact with brain cell targets
2. Compound that helps rice grow reduces nerve, vascular damage from diabetes
3. UT Southwestern researchers create molecule that nudges nerve stem cells to mature
4. Engineer develops detergent to promote peripheral nerve healing
5. Tumor-targeting viral therapy slows neuroblastoma, malignant peripheral nerve sheath tumors
6. Salk scientists identify key nerve navigation pathway
7. Team of scientists develops non-invasive method to track nerve-cell development in live human brain
8. West Nile virus spread through nerve cells linked to serious complication
9. Targeting nerve growth factor may cure liver cancer
10. Specific brain protein required for nerve cell connections to form and function
11. Senescence in liver cells is found by CSHL scientists to help limit acute tissue damage
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Antidepressants need new nerve cells to be effective, UT Southwestern researchers find
(Date:7/9/2014)... an associate professor of plant pathology and microbiology ... awarded the 2014 Alexopoulos Prize by the ... advancing the science of mycology the study of ... lichens, plant pathogens, and medically important fungi. , The ... early-career mycologist. Stajich received the award last month in ...
(Date:7/9/2014)... Research Centre (CNIO) have discovered that NANOG, an essential ... in stratified epitheliathose that form part of the epidermis ... vaginain adult organisms. According to the conclusions of the ... this factor could also play a role in the ... oesophagus and skin. , The pluripotency factor NANOG is ...
(Date:7/9/2014)... the puzzle behind nature,s ability to split the ... the development of artificial photosynthesis for clean, green ... international collaboration of scientists led by researchers with ... the SLAC National Accelerator Laboratory. , Working ... world,s most powerful x-ray laser, the researchers were ...
Breaking Biology News(10 mins):UC Riverside plant pathologist receives national recognition 2CNIO scientists discover that pluripotency factor NANOG is also active in adult organisms 2Postcards from the photosynthetic edge 2Postcards from the photosynthetic edge 3
... of Technology have created a new sampling device that ... pneumonia each year. Called PneumoniaCheck, the device created ... of diagnosing pneumonia, which is a major initiative of ... Pneumonia, an inflammation of the lungs, kills about ...
... a method based on geographic positioning systems that allowed ... in a way similar to how geographers characterize mountain ... that reflects how "rugged" the surface of the tooth ... the shearing molars in insect eaters and omnivores to ...
... 18, 2011) -- A University of Arizona College of ... robots for planetary exploration will be featured in a ... "WaveLengths." The robots will be featured on the ... MST on public television KUAT Channel 6. "WaveLengths" is ...
Cached Biology News:A better way to diagnose pneumonia 2A better way to diagnose pneumonia 3UMass Amherst biologists use GPS to 'map' bats teeth to explore evolutionary adaptations to diet 2Planetary exploration robots to be featured on science program 'WaveLengths' 2
(Date:1/15/2014)... JOSE, California , January 15, 2014 ... cancer, today announced the appointment of Thomas C Reynolds MD, ... 20 years, development experience gained in the biotechnology industry, most ... "I am delighted to welcome Tom at this transformative time ...
(Date:1/15/2014)... Reston, VA (PRWEB) January 15, 2014 ... education have continued their sponsorship of an annual competition ... interest in, and access to, innovative STEM study. The ... , TEAMS: Tests of Engineering Aptitude, Mathematics, and ...
(Date:1/15/2014)... AudioNotch is the internet's leading provider of ... of tinnitus. Patients listen to sound therapy that is ... of weeks to months, their tinnitus volume decreases. , AudioNotch ... Music and Notched White Noise. Now, AudioNotch is pleased to ...
(Date:1/14/2014)... , Jan. 14, 2014  3D Communications, a leading provider of ... regulatory, business, and media events in the United States ... former associate Virginia Cox , JD, is returning to the ... Virginia Cox re-joins 3D after more than two years of ...
Breaking Biology Technology:Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5Former FDA Associate Commissioner Returns To 3D Communications 2
... Wis. - Building the Merge Healthcare ... explains, will mean offshoring 150 jobs to a "more ... reduce 28 percent of the financially troubled medical imaging ... Japan to regain the competitive edge marks the centerpiece ...
... people, a natural biological response to the phrase securities law ... the outside of the cornea wall, coupled with a dull ... my best to stick to the essentials. As a result, ... company is raising capital, it is important to contact an ...
... Wisconsin organizers of Make Mine a $Million ... May as Wisconsin does its part to take one ... , ,Although the date of the awards program has ... including Make Mine a $Million members - soon will ...
Cached Biology Technology:Merge offshoring jobs to "more cost-effective" workforce 2Merge offshoring jobs to "more cost-effective" workforce 3Securities compliance is part of raising capital 2Securities compliance is part of raising capital 3Securities compliance is part of raising capital 4Make Mine a $Million shoots for May program 2Make Mine a $Million shoots for May program 3
The Trans-Blot Plus gel and cassette assembly tray is used to hold the Trans-Blot Plus gel holder cassette, buffer, and other materials for the gel and membrane sandwich during their assembly....
Criterion staining and blotting trays are plastic trays designed for staining one or two Criterion gels or performing western blot detection. The trays have a working capacity of up to 500 ml. Suppli...
... range of next-generation features into a small-footprint ... for flexible laboratory solutions. It puts every ... dilution, dispensing, and integrations into a ... flexible as it is efficient and economical. ...
... FX P is the latest entry in ... greater positional accuracy and increased robustness, it can ... It can be configured with either one or ... the Biomek FX P sets the standard ...
Biology Products: