Navigation Links
Anticancer compound found in American mayapple
Date:9/4/2009

VERONA, MSA common weed called American mayapple may soon offer an alternative to an Asian cousin that's been harvested almost to extinction because of its anti-cancer properties. The near-extinct Asian plant, Podophyllyum emodi, produces podophyllotoxin, a compound used in manufacturing etoposide, the active ingredient in a drug used for treating lung and testicular cancer. Podophyllyum emodi is a cousin of the common mayapple weed found in the United States.

Podophyllotoxin is found in Indian mayapple (Podophyllum emodii Wall.), American mayapple (Podophyllum peltatum L.), and other species. Podophyllotoxin and its derivatives are used in several commercially available pharmaceutical products such as the anticancer drugs etoposide, teniposide, and etopophos, which are used in the treatment of small-cell lung cancer, lymphoblastic leukemia, testicular cancer, and brain tumors. Podophyllotixin derivatives are also used for the treatment of psoriasis and malaria, and some are being tested for the treatment of rheumatoid arthritis. Currently, podophyllotoxin is produced commercially using the roots and rhizomes of Indian mayapple, an endangered species harvested from the wild in India, Pakistan, Nepal, and China.

Researchers at Mississippi State University and the University of Mississippi recently set out to identify American mayapple types with high podophyllotoxin content. Valtcho D. Zheljazkov and colleagues at Mississippi State University published the research results in HortScience. According to Zheljazkov; "The objective of this study was to estimate podophyllotoxin concentration in American mayapple across its natural habitats in the eastern United States and to identify high podophyllotoxin types that could be used for further selection and cultivar development."

Mayapple has been long been grown as a cash crop in Europe and Russia, but has never been introduced or domesticated in the United States, although the idea was suggested by researchers more than 30 years ago. Previous research demonstrated that American mayapple leaves contain podophyllotoxin, making way for the development of American mayapple as a high-value crop for American growers. Zheljazkov explained that, until now, there has been no comprehensive study on the genetic resources of American mayapple colonies across the United States. "We hypothesized that there might be great variation with respect to podophyllotoxin content within American mayapple across the eastern United States."

The researchers studied the effect of location, plant nutrient concentration, and phytoavailable nutrients in soil on podophyllotoxin concentration in American mayapple across its natural habitats in the eastern United States. The study was the largest of its kind ever conducted; American mayapple leaves were collected from 37 mayapple colonies across 18 states.

This groundbreaking study confirmed that mayapple colonies in the eastern part of the United States can be used for the development of high podophyllotoxin cultivars, which could subsequently provide the base for commercial production of podophyllotoxin in the United States. The results from this study will help to develop a Geographic Information System (GIS) map of the genetic resources of American mayapple in the U.S.


'/>"/>

Contact: michael W. Neff
mwneff@ashs.org
703-836-4606
American Society for Horticultural Science
Source:Eurekalert

Related biology news :

1. Certain anticancer agents could be harmful to patients with heart disease
2. Better beer: College team creating anticancer brew
3. New microsensor measures volatile organic compounds in water and air on-site
4. Naturally-occurring apple compounds reduce risk of pancreatic cancer
5. Chemical compound present in detergents produce bacteria alterations in agricultural soils
6. Synthetic compound promotes death of lung-cancer cells, tumors
7. Natural compound in broccoli could treat devastating genetic skin disorder
8. New form of compound stimulates research on hydrogen storage
9. Protein protects brain against compound in lead poisoning, liver disease
10. A compound extracted from olives inhibits cancer cells growth and prevents their appearance
11. UDs Bobev receives NSF Early Career Award for research on novel compounds of rare Earth metals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... 24, 2017 Research and Markets has announced ... Analysis & Trends - Industry Forecast to 2025" report to ... The ... a CAGR of around 15.1% over the next decade to reach ... analyzes the market estimates and forecasts for all the given segments ...
(Date:3/22/2017)... , March 21, 2017   Neurotechnology , ... recognition technologies, today announced the release of the ... which provides improved facial recognition using up to ... a single computer. The new version uses deep ... accuracy, and it utilizes a Graphing Processing Unit ...
(Date:3/20/2017)... , March 20, 2017 At this year,s ... -based biometrics manufacturer DERMALOG. The Chancellor came to the DERMALOG stand ... is this year,s CeBIT partner country. At the largest German biometrics ... in use: fingerprint, face and iris recognition as well as DERMALOGĀ“s multi-biometrics ... ...
Breaking Biology News(10 mins):
(Date:5/21/2017)... Diego, CA (PRWEB) , ... May 20, 2017 ... ... support tool that helps avoid the lengthy trial and error process by finding ... patients. It can also strengthen the doctor-patient relationship through a personalized approach ...
(Date:5/19/2017)... ... May 19, 2017 , ... ... Program. Academic researchers with technologies ripe for commercialization, and who are affiliated ... Delaware, are encouraged to submit proposals. QED, now in its tenth round, is ...
(Date:5/18/2017)... ... May 18, 2017 , ... ... Tapas Cooking Challenge is a two-hour team-building package designed for groups of 10-30 ... Chef Jodi Abel, which include items, such as Blackened Shrimp with Edamame Salad, ...
(Date:5/18/2017)... (PRWEB) , ... May 17, 2017 , ... NDA Partners ... executive and former CEO of Eurofins Advantar Laboratories and President of Pharmaceutical Development Business ... to his position at Eurofins and Cardinal Health, he was former Chief Operating Officer ...
Breaking Biology Technology: