Navigation Links
Antibody targeting of glioblastoma shows promise in preclinical tests, say Lombardi researchers
Date:7/31/2009

developing, it needs to constantly remodel itself," he says. "Glioblastoma appears to be another example of cancer that develops when embryonic genes are upregulated. As a result, brain tumor cells are extremely motile and can invade other parts of the brain very quickly."

In this latest research, Wellstein and his colleagues searched public databases, at the National Library of Medicine, to see if other studies that collected and analyzed glioblastoma and other brain tumor tissues also recorded expression of PTN and ALK, as well as genes along this pathway. "We found that they are significantly up regulated," he says. They then assessed whether that activity mattered to the outcome of patients with brain tumors. "A lot of pathways that are activated in cancer are passengers, in a sense. They don't drive cancer. But in the case of PTN and ALK, the expression data suggest that these are drivers patients with increased expression of these genes had significantly poorer outcomes in an analysis of different, independent studies."

Wellstein had also been working on a method to shut off the pathway. Several years ago, GUMC investigators found the "sweet spot" on ALK where PTN binds, which Wellstein says was a major discovery. "You can have hundreds of different areas on a receptor protein where its ligand could theoretically bind. We found just the right one."

They collaborated with ESBAtech in Switzerland who created a small single-chain antibody fragment in yeast that would itself bind to the sweet spot, blocking ALK's interaction with PTN. In the present study, the researchers successfully tested the antibody in human glioblastoma cells, and also showed that in mice implanted with human glioblastoma, the antibody prevented tumors from growing. For example untreated tumors grew to an average size of 350 cubic millimeters after three weeks, but treated tumors did not grow beyond their initial 25 cubic millimeters.

Wellstein says a ph
'/>"/>

Contact: Karen Mallet
km463@georgetown.edu
215-514-9751
Georgetown University Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. In vitro antibody production enables HIV infection detection in window period -- key to safer blood
2. NEWSLETTER: Antibody Fragment Production Breakthrough with 2nd Generation EBA
3. Novel antibody prevents infection by hepatitis C virus
4. Mass Biologic Labs/UMass Med School and Medarex license C. difficile monoclonal antibody to Merck
5. Antibody key to treating variant CJD, scientists find
6. UC San Diego and Genentech scientists develop potentially disruptive antibody sequencing technology
7. ETH Zurich researchers develop antibody test
8. Bright lights: Mystery of glowing antibody solved by Scripps research scientists
9. Yale chemist receives NIH Young Investigator Award for antibody targeting
10. Reversing cognitive deficits: Injectable antibody may attack source of problem
11. UCLA researchers discover new molecular pathway for targeting cancer, disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2014)... that after a long stay in the Intensive Care ... remain behind in patients, intestines. The team tested these ... when provoked by conditions that mimic the body,s stress ... mBio , the online open-access journal of the American ... treatment of ICU patients who can develop a life-threatening ...
(Date:9/22/2014)... cut grass in recent years has been identified as ... says the aroma also summons beneficial insects to the ... plant signals the environment via the emission of volatile ... for parasitic wasps to come to the plant that ... insect," said Dr. Michael Kolomiets, Texas A&M AgriLife Research ...
(Date:9/22/2014)... Scientists have discovered a key molecular cog in a ... of circadian (daily) rhythms based on temperature. , Transcription ... based on external stresses such as light, rain, ... team of researchers at USC has isolated one, called ... here and there as needed while in keeping it ...
Breaking Biology News(10 mins):Critically ill ICU patients lose almost all of their gut microbesand the ones left aren't good 2Critically ill ICU patients lose almost all of their gut microbesand the ones left aren't good 3Mown grass smell sends SOS for help in resisting insect attacks, researchers say 2Mown grass smell sends SOS for help in resisting insect attacks, researchers say 3Genetic switch regulates a plant's internal clock based on temperature 2
... January 14, 2013 Using an innovative approach, scientists ... structure of Ltn1, a recently discovered "quality-control" protein that ... and animals. Ltn1 appears to be essential ... also be relevant to human neurodegenerative diseases, for an ...
... 2013Taking a vitamin D supplement and drinking cow,s milk are ... D is in a child,s body, new research has found. ... colour and exposure to the sun, according to Dr. Jonathon ... "Early childhood is a critical stage in human development, so ...
... is Everywhere" tenet of bacterial distribution in the ocean, ... "bipolar" species of bacteria that occur in the Arctic ... they found even fewer bipolar species than would turn ... everywhere. "That suggests that there are forces that are ...
Cached Biology News:Scientists discover structure of protein essential for quality control, nerve function 2Scientists discover structure of protein essential for quality control, nerve function 3Supplements and cow's milk play biggest roles in determining vitamin D levels in children 2MBL scientists find 'bipolar' marine bacteria, refuting 'everything is everywhere' idea 2MBL scientists find 'bipolar' marine bacteria, refuting 'everything is everywhere' idea 3
(Date:9/23/2014)... , Sept. 23, 2014 /PRNewswire/ - Portage Biotech Inc. ... Exchange: PBT.U), is pleased to announce that its ... added two more  consultants to its team for ... uses a new proprietary cell permeable peptide platform ... anti-inflammatory cargo into the eye. ...
(Date:9/23/2014)... 23, 2014 Equashield ( ...     Devices  (CSTD) for hazardous drugs, ... Medical Technology Corporation.  Equashield,s leading CSTD has been ... , China and ... to expand globally, and throughout the ...
(Date:9/23/2014)... September 23, 2014 Healthcare ... globe will convene at the Society for ... be held October 26-28 in Houston, Texas ... and practice in individualized integrative cancer care. ... nurses, psychologists, nutritionists, naturopaths, acupuncturists, and other ...
(Date:9/22/2014)... Pearl's Premium Ultra Low Maintenance Lawn Seed ... seed this week with the release of their Pearl's ... the fact that it is time to plant now ... , As of the date 6/4/13, Pearl's Premium had ... experts and the media including: The National Gardeners ...
Breaking Biology Technology:Portage Announces New Consultants for its PPL-003 Development Programs 2Portage Announces New Consultants for its PPL-003 Development Programs 3Portage Announces New Consultants for its PPL-003 Development Programs 4Equashield Enters Taiwan Following Expansion to Australia, Japan, China 2International Medical Experts to Discuss Latest Integrative Oncology Research and Its Translation to Personalized Clinical Care at 11th International Conference of SIO 2International Medical Experts to Discuss Latest Integrative Oncology Research and Its Translation to Personalized Clinical Care at 11th International Conference of SIO 3Pearl's Premium Ultra Low Maintenance Lawn Seed Announces A Major Breakthrough In Drought Tolerant Grass Seed 2
... to 26 in Kansas City. , ... Rockville, MD ... Annual Scientific Meeting (ASM) will be held in Kansas City, Mo., ... with the USP experts responsible for establishing internationally recognized standards for ...
... 3 ESA Biosciences, a Magellan,Biosciences company and ... for pharmaceutical development and QA/QC, life science, and,analytical-chemistry ... Frost & Sullivan North American Technology Innovation Award ... Sullivan will present the,award to ESA,s Vice President ...
... HOUSTON, Sept. 3 US Oncology Specialty, LP, ... the Occupational Excellence Achievement Award from the National,Safety ... award is presented to companies who produce the ... To be eligible, organizations must report,days away from ...
Cached Biology Technology:USP's 2008 Annual Scientific Meeting to Convene Scientific Experts from Around the World 2USP's 2008 Annual Scientific Meeting to Convene Scientific Experts from Around the World 3ESA Receives 2008 Frost & Sullivan North American Technology Innovation Award for Development of Integrated Metabolomics Systems 2ESA Receives 2008 Frost & Sullivan North American Technology Innovation Award for Development of Integrated Metabolomics Systems 3US Oncology Pharmaceutical Distribution Service Wins National Safety Council Award 2
... to MKK6 (phospho S207) ( Abpromise ... Antigen: Synthetic phosphopeptide ... phosphorylation site of Serine 207 (V-D-S ... Gene ID: 5608 ...
Mouse monoclonal [1Q17] to TGE Virus peplomer ( Abpromise for all tested applications)....
CD45/CD34 combination 50 tests...
XPC Immunogen: XPC (NP_004619, 141 a.a. ~ 251 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
Biology Products: