Navigation Links
Antibody library project could unlock mysteries of human gene function

LOS ALAMOS, New Mexico, October 31, 2011 A National Institutes of Health (NIH) grant to Los Alamos National Laboratory Bioscience Division could help unravel the gnarly secrets of how many human genes function.

Originally discovered in the Human Genome Project, the approximately 20,000 genes of the human body have been slow to reveal their exact roles. And one of the best tools for exposing a gene's function is to take the protein it produces and generate specific antibodies, usually by vaccinating mice or rabbits. Antibodies are specialized proteins the immune system deploys to block the actions of potentially harmful bacteria and viruses.

By looking at antibodies, researchers can identify where, in a cell, genes are active and under what conditions they increase or decrease their expression. Antibodies are also one of the fastest growing classes of new therapeutics,with sales of about $40 billion in 2010.

With the new NIH Common Fund grant of more than $4 million, researchers led by Andrew Bradbury aim to develop an automated pipeline to generate antibodies against human gene products, without using animals.

Instead Dr. Bradbury's team will use "antibody libraries" expressed in bacteria and bakers yeast. These libraries are enormous, comprising billions of different antibodies, and the ultimate goal is to identify antibodies in the libraries that recognize each human protein. The broad availability of antibodies against all human proteins will facilitate the understanding of human disease and provide likely targets for therapeutic intervention, with the antibodies themselves potentially becoming therapeutic leads.

This project will leverage much of the technology that has been developed over the years at LANL, including flow cytometry, antibody libraries and fluorescentprotein technology, and has the potential to create a set of tools applicable to many different problems of interest to sponsors beyond NIH, including the U.S. Department of Energy and Department of Defense.


Contact: Nancy Ambrosiano
DOE/Los Alamos National Laboratory

Related biology news :

1. Xencor Initiates Phase 1 Study of XmAb®5871 Therapeutic Antibody for the Treatment of Autoimmune Diseases
2. B-lymphocyte depletion using the anti-CD20 antibody rituximab in chronic fatigue syndrome
3. Scientists report major advance in human antibody therapy against deadly Hendra virus
4. Powerful antibody-based strategy suggests a new therapeutic approach to diabetes and obesity
5. Humabs discovers the first antibody to neutralize both group 1 and group 2 influenza A viruses
6. Discovery of natural antibody brings a universal flu vaccine a step closer
7. Epitomics Signs Agreement With Bayer for Antibody Technology
8. Researchers discover trigger to early, effective antibody response
9. Plastic antibody works in first tests in living animals
10. USU scientists report major advance in human antibody therapy against deadly Nipah virus
11. First human gets new antibody aimed at rabies virus
Post Your Comments:
(Date:5/16/2016)... , May 16, 2016   EyeLock LLC , ... announced the opening of an IoT Center of Excellence ... and expand the development of embedded iris biometric applications. ... level of convenience and security with unmatched biometric accuracy, ... identity aside from DNA. EyeLock,s platform uses video technology ...
(Date:4/28/2016)... 28, 2016 First quarter 2016:   ... compared with the first quarter of 2015 The gross ... M (loss: 18.8) and the operating margin was 40% (-13) ... Cash flow from operations was SEK 249.9 M (21.2) , ... is unchanged, SEK 7,000-8,500 M. The operating margin for ...
(Date:4/15/2016)... Research and Markets has announced ... 2016-2020,"  report to their offering.  , ... global gait biometrics market is expected to grow ... 2016-2020. Gait analysis generates multiple variables ... to compute factors that are not or cannot ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June 23, 2016 /PRNewswire/ - FACIT ... Ontario biotechnology company, Propellon Therapeutics ... development and commercialization of a portfolio of first-in-class ... Epigenetic targets such as WDR5 represent an exciting ... significantly in precision medicine for cancer patients. Substantial ...
(Date:6/23/2016)... 2016  The Prostate Cancer Foundation (PCF) is pleased to announce ... cures for prostate cancer. Members of the Class of 2016 were selected from ... Read More About the Class of 2016 PCF Young Investigators ... ... ...
(Date:6/23/2016)... ... June 23, 2016 , ... STACS DNA Inc., the sample tracking ... Arkansas State Crime Laboratory, has joined STACS DNA as a Field Application Specialist. ... Jocelyn Tremblay, President and COO of STACS DNA. “In further expanding our capacity as ...
(Date:6/23/2016)... , June 23, 2016 ... Review, 2016;12(1):22-8 Published ... the peer-reviewed journal from touchONCOLOGY, Andrew D ... cost of cancer care is placing an increasing ... of expensive biologic therapies. With the patents on ...
Breaking Biology Technology: