Navigation Links
Antibody key to treating variant CJD, scientists find
Date:3/4/2009

Scientists at the University of Liverpool have determined the atomic structure of the 'binding' between a brain protein and an antibody that could be key to treating patients with diseases such as variant CJD.

Variant Creutzfeldt-Jakob Disease (vCJD) is part of a family of rare progressive neurodegenerative disorders, called prion diseases, which affect both animals and humans. It is thought that those who have developed vCJD became infected through the consumption of cattle products contaminated with Bovine Spongiform Encephalopathy (BSE) a brain disorder in cows, commonly known as Mad Cow Disease.

Prion diseases can develop when a naturally occurring brain prion protein called, PrP, comes into contact with infectious prions. This converts PrP into a form that has a different shape, and eventually leads to a build-up of protein in the brain, causing brain cells to die. It is thought that immunisation with antibodies that can 'stick' to PrP could treat and even prevent the development of the disease.

To understand the 'connection' between the antibody and the protein, scientists at Liverpool used X-ray crystallography technology to build a three-dimensional picture of the binding between an antibody called ICSM18 designed to 'stick' effectively to prion proteins and PrP cells.

Samar Hasnain, Professor of Molecular Biophysics at the University, explains: "To pin-point where the antibody 'sticks' to the protein we used X-ray crystallography, pioneered by Nobel Prize winner Max Perutz. Significantly we found that the point at which the protein and antibody came together was also where scientists at the Medical Research Council (MRC) Prion Unit had identified a single amino acid, which we now know has a significant impact on a patient's susceptibility to prion disease."

Scientists at the MRC Prion Unit, University College London, who collaborated on the research, have found that ICSM18 could help prevent brain ce
'/>"/>

Contact: Samantha Martin
samantha.martin@liv.ac.uk
44-151-794-2248
University of Liverpool
Source:Eurekalert

Page: 1 2

Related biology news :

1. UC San Diego and Genentech scientists develop potentially disruptive antibody sequencing technology
2. ETH Zurich researchers develop antibody test
3. Bright lights: Mystery of glowing antibody solved by Scripps research scientists
4. Yale chemist receives NIH Young Investigator Award for antibody targeting
5. Reversing cognitive deficits: Injectable antibody may attack source of problem
6. Studies point to novel target for treating arrhythmias
7. World breakthrough in treating premature babies
8. UC Davis discovery offers hope for treating kidney cancer
9. Pitt research identifies new target in brain for treating schizophrenia
10. Commercial aquatic plants offer cost-effective method for treating wastewater
11. New approach to treating cystic fibrosis lung infection shows promise
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... as the prolific bloomer Emiliania huxleyi , can ... The finding contradicts the common view that E. ... scarce supplies of thiamine in the ocean to survive. ... the ocean," says CIFAR Senior Fellow Alexandra Worden ... with CIFAR fellows John Archibald (Dalhousie University), ...
(Date:8/29/2014)... them, fold them: modern materials that are light, flexible ... artificial skin or electronic paper. , Making such concepts ... a new way of working with copper nanowires and ... , Previous success in the field of ultra-lightweight "aerogel ... gold and silver nanowires. , By turning instead ...
(Date:8/28/2014)... app called TX Invasives is now available from the ... Texas at Austin for identifying harmful non-native plant, insect ... in the United States cause about $137 billion in ... crops, clog waterways, kill native plants and more. , ... for reporting where invasive species occur, we,re more likely ...
Breaking Biology News(10 mins):Not all phytoplankton in the ocean need to take their vitamins 2Not all phytoplankton in the ocean need to take their vitamins 3Copper shines as flexible conductor 2Mobile app makes ID of harmful plants, insects in Texas a snap 2
... Spanish . , A new beetle that could be ... identified by Agricultural Research Service (ARS) scientists and cooperators. ... Thailand by entomologists Bob Pemberton (now retired), with the ARS ... Wright, with the ARS Australian Biological Control Laboratory (ABCL) in ...
... Presenting at the UK National Stem Cell Network ... a new approach to treating heart attack and cardiomyopathy ... Professor at Imperial College London, said "Recent clinical trials ... successful in terms of safety but unfortunately the bone ...
... State,s College of Agricultural Sciences will lead a seven-year, ... Liwang Cui, professor of entomology, is the principal investigator ... 10 International Centers of Excellence for Malaria Research announced ... part of the National Institutes of Health. About 40 ...
Cached Biology News:Scientists identify new potential biocontrol for skunk vine 2Improving clinical use of stem cells to repair heart damage 2Penn State to lead new international Center Of Excellence for malaria research 2Penn State to lead new international Center Of Excellence for malaria research 3
(Date:8/29/2014)... VANCOUVER , Aug. 29, 2014 /PRNewswire/ - ... (OTCQX: ICOTF), today reported financial results for the ... specified otherwise, are expressed in Canadian dollars and ... Second Quarter 2014 Highlights , ... visual acuity (VA) primary endpoint for subjects enrolled ...
(Date:8/29/2014)... California (PRWEB) August 29, 2014 ... of Energy's 2014 Hydrogen Production R&D Award ... -- by splitting water using sunlight. , Shared ... (NREL) and the University of Nevada, Las Vegas ... work developing models of photoelectrochemical solar-hydrogen production and ...
(Date:8/29/2014)... Boston, MA (PRWEB) August 29, 2014 ... ones in the biotech start-up dense realm of Boston-Cambridge, ... alliances and able investors. James Sherley, the Director of ... made increasing the local and national visibility of his ... in September 2013. , In addition to a social ...
(Date:8/28/2014)... SPIE Fellow Glenn Boreman, Professor and ... and Director of the Center for Optoelectronics and Optical ... and co-founder and Chairman of the Board of Plasmonics, ... Vice President of SPIE, the international society for optics ... recent election results at the Annual General Meeting of ...
Breaking Biology Technology:iCo Therapeutics Announces Second Quarter 2014 Financial Results 2iCo Therapeutics Announces Second Quarter 2014 Financial Results 3iCo Therapeutics Announces Second Quarter 2014 Financial Results 4Livermore Team Awarded for Hydrogen Production Research 2The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 2The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 3The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 4Glenn Boreman, UNC Professor and Plasmonics Co-Founder, Elected to SPIE Presidential Chain 2
... First to be Awarded Shingo Prize Outside of North ... ... International Inc.,s,(NYSE: BAX ) manufacturing facility in Cartago, Costa Rica has ... first to be awarded the Shingo Prize outside North America,-- is being ...
... with Cardiovascular and Digestive Disease ... ... Medical University,of South Carolina (MUSC) opens the doors of Ashley River ... digestive disease problems. Ashley River Tower marks the first step in,the ...
... 4 A recent study published this month,in the ... powder,and shampoo is linked to the presence of phthalates ... in a wide variety of everyday,products. They are used ... and can also be used to stabilize and make,fragrances ...
Cached Biology Technology:Baxter's Costa Rica Facility Recognized With Shingo Prize for Excellence in Manufacturing 2Medical University of South Carolina Opens State-of-the-Art Facility 2Medical University of South Carolina Opens State-of-the-Art Facility 3Medical University of South Carolina Opens State-of-the-Art Facility 4Statement by John Bailey, Chief Scientist: The Personal Care Products Council Response to Study on Phthalate Exposure in Baby Care Products 2
Anti-LC3 Polyclonal Antibody Research Focus: cell surface antigens Storage: -20C Shipping Temperature: +4C...
...
... biological cells for DNA isolation. ... plates (includes 96 well plate adapters ... across the entire plate length (max ... Can be used for soil, microorganisms, ...
... Chicken polyclonal to LYZL6 ( ... Antigen: Synthetic ... DYKSYSENLC HVDCQD , corresponding to amino ... Entrez Gene ID: ...
Biology Products: