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Antibiotics take toll on beneficial microbes in gut
Date:6/18/2009

nly used in the United States, related drugs such as cefoxitin are. The study findings suggest that it is really important to use antibiotics only when indicated, especially in people with health problems that might already compromise their gut microbe health, Young says. Multiple rounds of antibiotics may also deserve concern.

The findings will guide Young in related work in which he is using mouse models to examine how changes in the microbiota in the gut may influence how inflammatory bowel disease develops and progresses. The study will also inform ongoing research in his lab to gain insights into colitis associated with C. difficile infection. The Young laboratory recently published a study that demonstrates that long-term decreases in gut microbe diversity from repeated antibiotics are associated with recurring C. difficile infection in human patients.

Young cautions against concluding that popular probiotics supplements necessarily are safe and effective for everyone looking for a way to restore healthy gut microbes. An individual's specific health needs and vulnerabilities have to be considered. "Probiotics may be part of the solution, but we don't know that yet," he says.


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Contact: Anne Rueter
arueter@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert  

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