Navigation Links
Antibiotics: Change route of delivery to mitigate resistance

New research suggests that the rapid rise of antibiotic resistance correlates with oral ingestion of antibiotics, raising the possibility that other routes of administration could reduce the spread of resistance. The manuscript appears online ahead of print in the journal Antimicrobial Agents and Chemotherapy.

"For more than 40 years, a few doses of penicillin were enough to take care of deadly bacterial infections," says Hua Wang of the Ohio State University, Columbus, a researcher on the study. But since the 1980s, antibiotic resistance has been spreading rapidly, disabling once-powerful agents, leaving increasing numbers of patients to suffer, and even to die.

In earlier research, the investigators found a large cache of antibiotic resistance genes carried by nonpathogenic bacteria in many ready-to-consume food items. They also reported rapid development of resistant bacteria in infants who had not been exposed to antibiotics, shortly after birth, suggesting the gastrointestinal tract played a critical role in spreading resistance.

In the new research, the researchers inoculated lab mice with either Enterococcus species or Escherichia coli carrying specific resistance genes. The mice were then given tetracycline or ampicillin antibiotics, either orally, or via injection. Oral administration of antibiotics resulted in rapid rise of resistance genes as measured in the mice' feces. Resistance spread much less, and more slowly when the mice received antibiotics via injection.

The researchers also found that antibiotic resistance genes were not detectable in mice that had not been inoculated with bacteria containing antibiotic resistance genes, regardless of the route of antibiotic administration.

The human death toll from resistance, Wang says, is much higher than the 90,000 figure provided by the Centers for Disease Control and Prevention. The difference is due to the fact that bacterial inf

Contact: Jim Sliwa
American Society for Microbiology

Page: 1 2

Related biology news :

1. Surprise species at risk from climate change
2. DoD-funded research: Can climate change heat up conflict?
3. Land use changes, housing demographics shift in Washington State
4. Epigenetic changes mediated by homocysteine levels in plasma may point to schizophrenia
5. Experts find epigenetic changes moderate reality distortion in schizophrenia patients
6. Metabolic model of E. coli reveals how bacterial growth responds to temperature change
7. Alpine lakes reflect climate change
8. First evidence that the genome can adapt to temperature changes
9. Hidden effects of climate change may threaten eelgrass meadows
10. Microbial changes regulate function of entire ecosystems
11. UCLA life scientists present new insights on climate change and species interactions
Post Your Comments:
(Date:10/8/2015)... 8. Oktober 2015 Die Track ... Unternehmen des Bereiches Tracking, hat heute bekannt ... Gefängnisbehörde Virginias (Department of Corrections – DOC) ... für alle Strafen geliefert werden, die der ... Präsident für den Amerikanischen Kontinent der Track ...
(Date:10/7/2015)... -- --> --> According ... third quarter 2015 amounted to around 960 MSEK. This exceeds ... was communicated 20 August 2015. --> ... a continued growing demand for the company,s products, the revenues ... than during the third quarter. The revenue guidance for 2015 ...
(Date:10/6/2015)... 2015 Track Group, Inc. (OTCQX: TRCK), a ... signed a contract with the Virginia Department of Corrections ... of sentences under the Department,s oversight. Derek ... contract with the Virginia DOC will expand our footprint ... our position as a trusted leader in offender electronic ...
Breaking Biology News(10 mins):
... (Dec. 20, 2007) -- At its core, healthy neurological function ... via the synapse. Figuring out how the synapse traffics ... to understanding the function of the healthy and diseased brain. ... Cornell Medical College in New York City has spotted a ...
... East Anglia has discovered the existence of grandparent helpers in ... rarely occurs except in humans, has been observed in birds. ... a population on Cousin Island in the Seychelles has revealed ... themselves often help their children to raise grandchildren. The ...
... Ph.D, a University of Alabama at Birmingham (UAB) professor ... Czech Mind prize. The annual award is ... recipients often include Czech nationals working in other countries. ... to research and teach about the microbial environment of ...
Cached Biology News:
(Date:10/8/2015)... 2015 Celemics, a global pioneer of personalized ... American market with the establishment of Celemics America, Inc. ... Europe , has secured itself in the ... and sample preparation for DNA sequencing and genetic testing.  ... somatic genetic testing more accurately, quickly, and cost effectively ...
(Date:10/8/2015)... 2015  Today, DuPont and Caribou Biosciences, a ... jointly announced a strategic alliance. As part of ... patent portfolios, with DuPont receiving exclusive intellectual property ... crops, and non-exclusive rights in other agricultural and ... --> In addition, the alliance ...
(Date:10/8/2015)... , Oct. 8, 2015  Sigma-Aldrich Corporation ... Cerilliant ® brand within its Applied Diagnostics ... bile acid reference standards product line with ten ... routinely tested bile acids and their stable-labeled internal ... consist of lithocholic acid, taurocholic acid and native ...
(Date:10/7/2015)... 8, 2015 ... accounts for largest bioinformatics market share due ... discovery and development process says this research ... . --> ... of applications, the bioinformatics market is segmented ...
Breaking Biology Technology:
... materials to study their structure and behavior, thanks to work ... and the Lawrence Berkeley National Laboratory and published Aug. 14 ... will enable more detailed study of new types of materials ... The technique, called angle-resolved photoemission, has been used since ...
... Regeneron Pharmaceuticals, Inc. (Nasdaq: REGN ) today ... Food and Drug Administration (FDA) that the agency has ... of the EYLEA Biologics License Application (BLA) for the ... November 18, 2011, which is a three month extension ...
... Elsevier, a world-leading provider of scientific, technical and ... University of Singapore (NUS), a leading global university ... This "Hackathon", a 24-hour programming competition, encourages students ... the search and discovery process of scientific information. ...
Cached Biology Technology: