Navigation Links
Antibiotic offers potential for anti-cancer activity
Date:1/28/2011

INDIANAPOLIS An antibiotic known for its immunosuppressive functions could also point the way to the development of new anti-cancer agents, researchers at the Indiana University School of Medicine have reported.

The study determined that the compound, tautomycetin, targets an enzyme called SHP2, which plays an important role in cell activities such as proliferation and differentiation. Interestingly, SHP2 mutations are also known to cause several types of leukemia and solid tumors. The findings were reported in the Jan. 28, 2011, issue of the journal Chemistry and Biology.

The potential for developing anti-cancer agents grew out of an attempt to determine how the compound, tautomycetin, exerts its immune suppression activities, said Zhong-Yin Zhang, Ph.D., Robert A. Harris Professor and chairman of the Department of Biochemistry and Molecular Biology.

The finding is also encouraging because SHP2 is a member of a large family of enzymes called protein tyrosine phosphotases (PTPs), which are important in the signaling processes that control all essential cellular functions. Dysregulation of PTP activity has been linked to several human diseases, including cancer, diabetes, and immune dysfunctions. But their makeup has made it difficult to find potential drugs to act on them, characteristics that have labeled the PTPs as "undruggable," Dr. Zhang said.

"So we have identified a lead a natural product produced by the bacteria Streptomyces that should serve as a foundation for the development of therapeutic agents for a large family of protein tyrosine phosphotase targets. Until now these targets, including SHP2 for leukemia and other cancers, have been deemed undruggable," he said.


'/>"/>

Contact: Eric Schoch
eschoch@iupui.edu
317-274-7722
Indiana University School of Medicine
Source:Eurekalert

Page: 1

Related biology news :

1. Common antibiotics and blood pressure medication may result in hospitalization
2. Virginia Tech engineer identifies new concerns for antibiotic resistance, pollution
3. University of Minnesota engineering researcher finds new way to fight antibiotic-resistant bacteria
4. Antibiotics have long-term impacts on gut flora
5. FSU researchers examine how bacteria become resistant to antibiotics
6. Antibiotic appears safe for stroke patients and good companion for tPA
7. Cockroach brains could be rich stores of new antibiotics
8. Insect brains are rich stores of new antibiotics
9. Ancient brew masters tapped antibiotic secrets
10. Ants found to use multiple antibiotics as weed killers
11. Antibiotic may reduce stroke risk and injury in diabetics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/10/2015)... According to a new ... (Ultrasound, TOF, Structured Light, Stereo Vision), Type(Image, Position, ... by Geography - Trends & Forecast to 2014 ... expected to reach $3,319.71 Million by 2020, growing ... 2020. Browse 71 market data tables ...
(Date:6/9/2015)... , June 09, 2015 Research and ... of the "Gesture Recognition & Touchless Sensing ... Electronics, Automotive, & Others), Product (Biometric & Sanitary ... 2020" report to their offering. ... is expected to reach $ 23.55 Billion by ...
(Date:6/8/2015)... , June 8, 2015  The Secure ... their selection of Troy Potter of ... immediately. SIBA is a non-profit association that was ... policy, education and implementation of solutions that protect ... ...
Breaking Biology News(10 mins):3D Sensor Market Worth $3,319.71 Million by 2020 23D Sensor Market Worth $3,319.71 Million by 2020 33D Sensor Market Worth $3,319.71 Million by 2020 4Global Gesture Recognition & Touchless Sensing (Technology, Application & Products) Market 2015-2020 2Secure Identity & Biometrics Association (SIBA) Names Troy Potter of L-3 National Security Solutions as Chairman 2Secure Identity & Biometrics Association (SIBA) Names Troy Potter of L-3 National Security Solutions as Chairman 3Secure Identity & Biometrics Association (SIBA) Names Troy Potter of L-3 National Security Solutions as Chairman 4Secure Identity & Biometrics Association (SIBA) Names Troy Potter of L-3 National Security Solutions as Chairman 5
... Researchers at the Georgia Institute of Technology are using ... also known as ARPA-E to pursue two ... the flue gases of coal-burning power plants. ... dioxide emitted in the United States each year. ...
... -- Ben-Gurion University of the Negev,s (BGU) Dr. Moshe Herzberg ... Research Center (BERC) in Nablus received a significant grant to ... East. This study brings together Israelis and Palestinians to address ... over a five-year period. The US-AID ...
... (BMI), a DuPont subsidiary, will lead one of 15 ... energy efficiency of American homes ─ the Building America ... the U.S. Department of Energy (DOE), will receive a ... 18 months to deliver innovative energy efficiency strategies to ...
Cached Biology News:ARPA-E funding supports research on carbon dioxide removal from flue gases 2ARPA-E funding supports research on carbon dioxide removal from flue gases 3ARPA-E funding supports research on carbon dioxide removal from flue gases 4NJIT to help lead public/private partnership to develop high-efficiency homes 2
(Date:7/1/2015)... ... , ... Apex Therapeutics announced today that company CEO, David Broecker provided a ... The presentation took place on Tuesday, June 16 and provided an update on the ... the treatment of pancreatic cancer. A copy of the company overview can be ...
(Date:6/30/2015)... , June 30, 2015 /PRNewswire/ - Resverlogix Corp. ... common shares of Resverlogix have approved the resolutions ... Capital Limited of 5,600,000 units at a price ... each unit being comprised of one common share ... proceeds of approximately CAD$15 million; and (ii) the ...
(Date:6/30/2015)... CA (PRWEB) , ... June 30, 2015 , ... ... Patients , Study will provide new insights on mechanics of fecal microbiota transplantation ... new partnership to study the microbiome of patients undergoing fecal microbiota transplantation (FMT) ...
(Date:6/30/2015)... 2015  The University of California, San Diego,s ... UC San Diego Extension announced their third annual ...  12 – 14, 2015, at UC San Diego ... an intense exposure to best practices and the ... to biologists, process engineers and business executives planning ...
Breaking Biology Technology:Apex Therapeutics Presented Company Overview at This Year’s BIO International Convention in Philadelphia, PA 2Resverlogix Corp. Shareholders Approve Matters Relating to Licensing and Equity Arrangement 2Resverlogix Corp. Shareholders Approve Matters Relating to Licensing and Equity Arrangement 3uBiome and OpenBiome Partner for Microbiome Study in FMT Patients 2uBiome and OpenBiome Partner for Microbiome Study in FMT Patients 3UC San Diego Extension to Offer Third Annual Microbial Fermentation Workshop 2
... PRINCETON, N.J., Oct. 26 Pharmasset, Inc.,(Nasdaq: VRUS ) management ... -- Acumen BioFin Rodman & Renshaw 9th Annual Healthcare Conference ... the New York Palace Hotel in New York ... Officer, will provide an overview of the company ...
... -- WuXi PharmaTech (NYSE:,WX), China,s premier provider of ... been ranked the 28th in the Deloitte Technology,Fast ... fastest growing technology,companies in China. The awards ceremony ... Tomorrow Square, Shanghai on October 25. (Logo: ...
... San Diego on November 2nd and New York ... Favrille, Inc. (Nasdaq:,FVRL), a biopharmaceutical company developing ... announced that the,Company will present at three upcoming ... -- Richard Ghalie, M.D., Chief Medical Officer, will ...
Cached Biology Technology:Pharmasset to Present at Three Investor Conferences in November 2007 2WuXi PharmaTech (NYSE: WX) Ranked the 28th of Deloitte Technology Fast 50 China 2Favrille to Present at BIOCOM Investor Conference, Acumen BioFin Rodman & Renshaw Healthcare Conference and CIBC World Markets Healthcare Conference 2
Human RXR beta/NR2B2 MAb (Clone H7341) Keywords: RXRbeta, RXRbeta, Retinoid X Receptor beta...
Human SOST Affinity Purified Polyclonal Ab...
BOND ELUT MATRIX-C18, 25 mg ...
Prepared from plasminogen by activation with immobilized human uPA...
Biology Products: