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Antibiotic may reduce stroke risk and injury in diabetics
Date:8/23/2010

y minocycline works is by blocking MMPs. Less directly, diabetes drugs like metformin, used to lower blood sugar, also reduce MMP levels.

Another MCG research team, led by Dr. David Hess, stroke specialist and chairman of the Department of Neurology, is showing that minocycline given alone or with tPA, the clot dissolver that is the only FDA-approved stroke treatment, can also work after a stroke to help minimize damage. One great synergy about the pair is that tPA increases bleeding risk and minocycline decreases it.

That could particularly benefit diabetics who already are at increased risk for bleeding, particularly when oxygen is restored to that area of the brain. This damage called a reperfusion injury is a primary reason that a diabetic stroke may look small on a magnetic resonance image but can have a devastating, effect, Ergul also has found.

Some of her next studies will include giving both tPA and minocycline to diabetic rats to study bleeding and the impact of the two drugs on blood vessels, particularly the tiny ones that are tightly connected to brain cells.


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Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

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