Navigation Links
Antibiotic appears safe for stroke patients and good companion for tPA
Date:9/13/2010

An antibiotic appears to be a safe treatment for stroke and a good companion therapy for tPA, the clot buster that is currently the only FDA-approved drug therapy, researchers report.

A safety study in 60 stroke patients in Georgia, Kentucky and Oregon found the drug well tolerated even at three-and-one-half times the dose currently used for conditions such as rheumatoid arthritis, according to a research team led by the Medical College of Georgia and the University of Georgia.

"It's cheap, safe, well tolerated, easy to administer and can be given with tPA," said Dr. David Hess, chairman of the Department of Neurology in the MCG School of Medicine and corresponding author on the study in Stroke.

"This is an old drug that has been studied extensively in healthy young people," said Dr. Susan C. Fagan, professor of pharmacy at UGA, assistant dean for the MCG program of the UGA College of Pharmacy and the study's first author. "Now that we know it's also safe in a predominantly older stroke population, we can look more closely to identify the dose necessary to give us the pharmacologic effect we need."

The researchers want to find a dose that can be used effectively in any patient, regardless of weight, so it can be given easily, even during transport to a hospital, Hess said. They saw no significant adverse effects in doses ranging from 200 to 700 milligrams.

The broad spectrum antibiotic, in use since the 1960s for a variety of infections, is currently prescribed as an anti-inflammatory for diseases such as arthritis. MCG and UGA animal studies indicate that the drug also reduces stroke damage in multiple ways inhibiting white blood cells and enzymes that can destroy brain tissue and blood vessels immediately after a stroke and reducing brain cell suicide in the hours following a stroke.

The early-stage clinical trial funded by the National Institutes of Health, opens the door to a much larger clinical trial assessing the antibiotic's efficacy, Hess said. The researchers are pursuing federal funding for a 2,000-patient international trial.

In preparation, they are looking at recipients of the largest minocycline dose in the small trial to measure the impact on levels of stroke-associated inflammatory factors. They are also studying the drug's effect on matrix metalloproteinases, or MMPs, which are released during stroke and destroy the basement membrane of blood vessels and cause bleeding. Bleeding can significantly worsen stroke damage and is a major side effect of tPA.

Hess and Fagan believe the drugs can work synergistically to improve stroke outcomes.

Sixty percent of the patients in their study also received tPA. While they know these patients had lower MMPs levels because of minocycline treatment, the study was too small to accurately assess outcomes, Fagan said. Researchers suspect that tPA's bleeding risk is a major reason why nearly 15 years after FDA approval, fewer than 5 percent of hospitalized stroke patients get the clot buster.

In related research, MCG scientists have shown minocycline may be beneficial even before a stroke. Work led by Dr. Adviye Ergul, physiologist in the MCG Schools of Medicine and Graduate Studies, showed in diabetic rats that a daily dose of the drug reduces remodeling of blood vessels in the brain that increases stroke risk. The drug also helps stop bleeding that often follows a stroke. Diabetes dramatically increases stroke and heart attack risk. The work was published in August in the Journal of Cerebral Blood Flow and Metabolism.

While antibiotic resistance resulting from overuse has become a major health concern in the country, Fagan noted minocycline's use in stroke wouldn't contribute to the problem since it will only be given for a few days. In fact, the researchers found the drug remained active in the body longer in their older stroke patients than in younger patients receiving it for other reasons, which means the patients likely will only need a single dose for three days. She and Hess have been exploring minocycline's stroke potential for a decade.


'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

Related biology news :

1. New way to make malaria medicine also first step in finding new antibiotics
2. Groundbreaking discovery may lead to stronger antibiotics
3. New antibiotic candidates from Braunschweig
4. Biomedical engineers detective work reveals antibiotic mechanism
5. Transporting broiler chickens could spread antibiotic-resistant organisms
6. Fewer deaths with preventive antibiotic use
7. Blue light destroys antibiotic-resistant staph infection
8. Research could lead to new non-antibiotic drugs to counter hospital infections
9. Genetic switch potential key to new class of antibiotics
10. Newly discovered reactions from an old drug may lead to new antibiotics
11. Antibiotics take toll on beneficial microbes in gut
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Antibiotic appears safe for stroke patients and good companion for tPA
(Date:2/3/2016)... --> --> Fourth quarter 2015:   ... fourth quarter of 2014. Gross margin was 46% (32). ... Earnings per share increased to SEK 6.39 (loss: 0.49). Cash ... --> --> January to December ... 1,142% compared with 2014. Gross margin was 43% (31). ...
(Date:2/3/2016)... http://www.researchandmarkets.com/research/d8zjcd/emotion_detection ) ... "Emotion Detection and Recognition Market by Technology ... Tools (Facial Expression, Voice Recognition and Others), ... Global forecast to 2020" report to ... ) has announced the addition of the ...
(Date:2/2/2016)... 2, 2016 Checkpoint Inhibitors for Cancer ... Are you interested in the future of ... checkpoint inhibitors. Visiongain,s report gives those predictions to ... national level. Avoid falling behind in data ... and revenues those emerging cancer therapies can achieve. ...
Breaking Biology News(10 mins):
(Date:2/9/2016)... February 9, 2016 Three-Year Initiative Supports ... to Take Part in Life-Changing Camp ... designed to positively affect the lives of children born with rare ... --> SHPG ) is announcing a new initiative designed to ... well as the future of rare disease care. --> ...
(Date:2/8/2016)... Feb. 8, 2016 Should antibiotic bone cement ... products to prevent infection after standard total hip or ... at ECRI Institute have been fielding a lot lately. ... Your Bottom Line?" --> "Antibiotic ... --> While there isn,t a ...
(Date:2/8/2016)... ... 08, 2016 , ... Thomas J. Todorow has joined the ... for Corporate Services and the Chief Financial Officer at The Children’s Hospital of ... Managed Care Contracting, Supply Chain, and Investments. , Prior to joining CHOP and ...
(Date:2/8/2016)... ... February 08, 2016 , ... Franz Inc. , an ... technology, today announced the availability of AllegroGraph 6, the leading Semantic Graph Database ... Certified Technology Program (CCPT). AllegroGraph is the first Semantic Graph Database to ...
Breaking Biology Technology: