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Antibacterial protein's molecular workings revealed
Date:2/21/2013

anganese and then targeting those microbial processes in new therapeutic strategies, Chazin and Skaar noted.

"We do not know all of the processes within Staph that require manganese; we just know if they don't have it, they die," Skaar said. "If we can discover the proteins in Staph that require manganese the things that are required for growth then we can target those proteins."

The team recently was awarded a five-year, $2 million grant from the National Institute of Allergy and Infectious Diseases (AI101171) to advance their studies of calprotectin and how it works to limit bacterial infections and in other inflammatory conditions.

"Nature stumbled onto an interesting antimicrobial strategy," Chazin said. "Our goal is to really tease apart the importance of metal binding to all of calprotectin's different roles and to take advantage of our findings to design new antibacterial agents."


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Contact: Leigh MacMillan
leigh.macmillan@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
Source:Eurekalert

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