Navigation Links
Antibacterial peptide could aid in treating soldiers' burn wound infections
Date:8/31/2010

An antibacterial peptide developed by Laszlo Otvos, a research professor of biology in Temple's College of Science and Technology, looks to be a highly-effective therapy against infections in burn or blast wounds suffered by soldiers.

Otvos and his collaborators found that when given intramuscularly the peptide A3-APO was more effective than current antimicrobial chemotherapy measures in treating multidrug-resistant Acinetobacter baumannii, the most common systemic infection found in soldiers who suffer burn or blast wounds. The peptide is also highly efficacious in models of multi-drug resistant systemic Escherichia coli infections.

Their findings are being published in the Journal of Antimicrobial Chemotherapy.

Otvos said that 40 percent of gowns and gloves in military hospitals are infected with Acinetobacter baumannii, and half of the soldiers returning from Iraq and Afghanistan with burn wounds will become infected.

Currently, these infections are treated with an antibiotic, either imipenem or colistin. However, both of these rapidly lose efficacy due to high rates of antimicrobial resistance. In addition, colistin is a strongly toxic drug and worldwide research is focusing on its replacement options.

For their study, the researchers used a strain of Acinetobacter baumannii isolated from an injured Canadian soldier returning from Afghanistan for testing in the lab. They found that A3-APO, when given intramuscularly, was less toxic and more effective in reducing bacterial counts in the blood and the injury site than imipenem or colistin. The peptide also protected open wounds from environmental bacterial infection.

"This is the first peptide ever that is more efficacious in an animal model than anything else that is available," said Otvos, who hopes the peptide can be tested in clinical trials in the near future.


'/>"/>

Contact: Preston M. Moretz
pmoretz@temple.edu
215-204-4380
Temple University
Source:Eurekalert

Page: 1

Related biology news :

1. Antibacterial silver nanoparticles are a blast
2. Mineral studies advance antibacterial alternatives
3. Insulin peptide may point to a solution for type 1 diabetes
4. Stress peptide and receptor may have role in diabetes
5. Scientists watch as peptides control crystal growth with switches, throttles and brakes
6. Peptides-on-demand: McGill researchers radical new green chemistry makes the impossible possible
7. Co-conspirator cells could hold key to melanoma prediction, prevention
8. Deep plumes of oil could cause dead zones in the Gulf
9. Stem cell versatility could help tissue regeneration
10. Research could change course of treatment for cancer that spreads to bones
11. Implantable silk metamaterials could advance biomedicine, biosensing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2017)... , May 16, 2017  Veratad Technologies, LLC ... of online age and identity verification solutions, announced today ... Identity Conference 2017, May 15 thru May 17, 2017, ... Building and International Trade Center. Identity ... globe and in today,s quickly evolving digital world, defining ...
(Date:4/18/2017)... 2017  Socionext Inc., a global expert in SoC-based imaging and ... the M820, which features the company,s hybrid codec technology. A demonstration ... Probe, Inc., will be showcased during the upcoming Medtec Japan at ... the Las Vegas Convention Center April 24-27. ... Click here for an ...
(Date:4/11/2017)... Apr. 11, 2017 Research and Markets has ... report to their offering. ... The global eye tracking market to grow at a CAGR of ... Eye Tracking Market 2017-2021, has been prepared based on an in-depth ... market landscape and its growth prospects over the coming years. The ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... BALTIMORE, Md. (PRWEB) , ... October 11, 2017 ... ... for digital pathology, announced today it will be hosting a Webinar titled, “Pathology ... of  Advanced Pathology Associates , on digital pathology adoption best practices and how ...
(Date:10/11/2017)... ... 11, 2017 , ... Singh Biotechnology today announced that the ... its novel anti-STAT3 (Signal Transducer and Activator of Transcription 3) B VHH13 single ... the cell membrane and bind intracellular STAT3 and inhibit its function. Dysregulation of ...
(Date:10/10/2017)... 2017 International research firm Parks Associates announced today ... the TMA 2017 Annual Meeting , October 11 in ... home security market and how smart safety and security products impact the ... Parks Associates: Smart Home Devices: ... "The residential security market has experienced ...
(Date:10/9/2017)... ... ... The award-winning American Farmer television series will feature 3 Bar Biologics in ... 8:30aET on RFD-TV. , With global population estimates nearing ten billion people by ... feed a growing nation. At the same time, many of our valuable resources are ...
Breaking Biology Technology: