Navigation Links
Anti-inflammatory drugs (coxibs) interfere with aspirin's clotting ability -- Ben-Gurion U.
Date:12/23/2009

BEER-SHEVA, ISRAEL -- December 23, 2009 -- A new study conducted at Ben-Gurion University of the Negev (BGU) reveals that Celebrex and other anti-inflammatory coxib medications may counter the positive effects of aspirin in preventing blood clots.

The research, published in the Proceedings of the National Academy of Sciences (PNAS), indicates that people who are taking aspirin and coxibs together are in fact inhibiting the aspirin's effectiveness in preventing heart attacks and strokes.

"This finding strongly suggests that humans who are consuming coxibs and a low dose of aspirin simultaneously are exposed to a greater risk of cardiovascular events," said Professor Gilad Rimon, Department of Clinical Pharmacology, Ben-Gurion University of the Negev in Israel.

In the past decade, a new group of anti-inflammatory drugs, coxibs, which include Celebrex and Arcoxia was developed to treat arthritis as well as other pain. Arthritis patients who take Celebrex are instructed to take low-dose aspirin to counteract Celebrex's own potential clot-promoting effect.

Aspirin is the oldest and one of the most effective non steroidal anti-inflammatory drugs. It is also well known for its ability to prevent the blood clots that can potentially lead to heart attack and stroke. Therefore, doctors often advise patients who are more prone to heart-related illnesses to take a daily tablet of low dose aspirin (81 mg). Approximately, 50 million Americans take aspirin every day to reduce their risk of cardiovascular diseases.

Now, the BGU research suggests that in the presence of coxibs, asprin's protective role in preventing new blood clots is blunted.

This finding mirrors a cooperative study conducted at the University of Michigan, Ann Arbor that showed for the first time that Celebrex and other coxibs directly interfere with the protective qualities of aspirin.


'/>"/>

Contact: andrew lavin
andrewlavin@alavin.com
516-944-4486
American Associates, Ben-Gurion University of the Negev
Source:Eurekalert

Page: 1

Related biology news :

1. Anti-inflammatory drug blocks brain plaques
2. The quest for specific anti-inflammatory treatment
3. Funxional successfully completes initial clinical trial of FX125L, an anti-inflammatory drug with a novel mechanism of action
4. Carnegie Mellon scientists develop nanogels that enable controlled delivery of carbohydrate drugs
5. Socioeconomic position associated with effectiveness of HIV drugs
6. Using green chemistry to deliver cutting-edge drugs
7. MIT model could improve some drugs effectiveness
8. Plants can be used to study how and why people respond differently to drugs
9. Insulins brain impact links drugs and diabetes
10. Scientists unveil structure of molecular target of many drugs
11. Market testing of dietary supplements and drugs underscores value of USPs public health programs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/15/2014)... experts who study the deadliest infectious diseases recognized the ... professors at the University of Texas Medical Branch, with ... Symposium on Filoviruses. The filoviruses include Ebola and Marburg ... of people infected. The current outbreak of Ebola virus ... deaths so far. , "This award represents the ...
(Date:4/15/2014)... loveliest in the world, but they also contain a ... become enriched in cadmium. Grasses take up this toxic ... and sheep that graze them. The problem is not ... , The concern is that if cadmium concentrations rise ... health and New Zealand,s agricultural economy could be jeopardized. ...
(Date:4/15/2014)... Netherlands Academy of Arts and Sciences (KNAW) has announced ... been awarded prestigious Heineken Prizes (one million US dollars ... Prizes for their great merits to science. , This ... Prize, awarded to the Austrian-American chemist Erwin Chargaff in ... Heineken Prizes to the following laureates: , ...
Breaking Biology News(10 mins):International research group recognizes UTMB experts 2International research group recognizes UTMB experts 3Five scientists awarded prestigious Heineken Prizes 2
... Most of what we have come to think of as ... ancestors. Over hundreds and thousands of years, humans have ... traits such as bigger, juicier, and easier-to-harvest fruits, stems, tubers, ... relatively easy to envision how such human-induced selection rapidly led ...
... Bureau of Reclamation has awarded a $3 million five-year ... integrated transponders (PIT) and related equipment to conduct on-going ... numerous river habitat restoration and endangered fish recovery programs. ... real-time, scientific knowledge about fish behavior that we rely ...
... Department of Energy (DOE),s Joint BioEnergy Institute (JBEI) have identified ... fuel for diesel engines but would be clean, green, renewable ... synthetic biology, a JBEI research team engineered strains of two ... to bisabolane, a member of the terpene class of chemical ...
Cached Biology News:Do long-lived crops differ from annual crops in their genetic response to human domestication? 2Do long-lived crops differ from annual crops in their genetic response to human domestication? 3Contract awarded for equipment to support on-going fish studies in the West 2JBEI identify new advanced biofuel as an alternative to diesel fuel 2JBEI identify new advanced biofuel as an alternative to diesel fuel 3JBEI identify new advanced biofuel as an alternative to diesel fuel 4
(Date:1/15/2014)... January 15, 2014 This webinar ... on nonclinical and clinical safety assessment in biosimilars. ... guide a path for biosimilar drug development, however ... of biosimilarity with regards to quality, safety and ... of biosimilar drug development and registration, development strategies ...
(Date:1/15/2014)... NC (PRWEB) January 15, 2014 ... an enhancement to its Online Web Portal for Life ... now have the ability to specify the subject matter ... nearly 50 life science sub-domains. This will help reduce ... and scientific fields, and decrease the likelihood of error. ...
(Date:1/14/2014)... Doylestown, PA (PRWEB) January 14, 2014 ... – 11 p.m. , Location: Warrington Country Club, 1360 ... Hepatitis B Foundation, the only national nonprofit organization solely ... improving the quality of life for those affected worldwide, ... 11 at Warrington Country Club in Warrington, Pa. ...
(Date:1/14/2014)... York, NY (PRWEB) January 14, 2014 ... initiated coverage of Alliqua, Inc. (OTCQB: ALQA). Alliqua ... and marketing proprietary products to serve the wound ... , In late 2012, Alliqua was restructured ... launched the company’s new strategy to become a ...
Breaking Biology Technology:Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2DTS Improves Efficiency for Life Science Document Translations 2Hepatitis B Foundation to Host Annual Crystal Ball Gala 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3
... Bulletin Board: DSCI), a provider of advanced wound care ... six months ended,June 30, 2008. Sales were up by ... the Company,s new First Aid Division as,well as the ... second quarter in 2008, the company reported sales of ...
... -- Michael Philen, assistant professor of aerospace and ocean ... Associated Universities (ORAU) Ralph E. Powe Junior Faculty Award. ... flexible matrix composites, which are new material and structural ... on demand. , "I believe these innovative materials ...
... At the upcoming Medical,Grade Polymers Conference, Dr. Remi ... Elastomer Gels: New Soft Adhesives for Wound,Care." The ... According to Dr. Thiria, silicones offer a ... features for wound care,scar management and transdermal drug ...
Cached Biology Technology:Derma Sciences Reports Second Quarter 2008 Results 2Derma Sciences Reports Second Quarter 2008 Results 3Derma Sciences Reports Second Quarter 2008 Results 4Derma Sciences Reports Second Quarter 2008 Results 5Bluestar Silicones Presents Adhesive Gels for Wound Care at Medical Grade Polymers Conference 2