Navigation Links
Anti-cancer drug prevents, reverses cardiovascular damage in mouse model of premature aging disorder
Date:10/6/2008

An experimental anti-cancer drug can prevent -- and even reverse -- potentially fatal cardiovascular damage in a mouse model of progeria, a rare genetic disorder that causes the most dramatic form of human premature aging, National Institutes of Health (NIH) researchers reported today.

In a study published in the Oct. 6 early online edition of the Proceedings of the National Academy of Sciences, a team led by Francis S. Collins, M.D., Ph.D., of the National Human Genome Research Institute (NHGRI), and Elizabeth G. Nabel, M.D., director of the National Heart, Lung and Blood Institute (NHLBI), describes its effort to use transgenic mice to identify and test potential therapies for children with Hutchinson-Gilford progeria syndrome.

There currently are no treatments for progeria, which is estimated to affect about one child in 4 million. At birth, children with progeria appear normal. But soon growth slows, and the children begin to show signs of accelerated aging, such as hair loss, wrinkled skin and loss of body fat. The most lethal damage, however, occurs within the children's major blood vessels. The children develop premature cardiovascular disease, which typically leads to death from heart attack or stroke at about the age of 13.

Building upon its past experiments in cells and mice, the NIH-led team examined the effects of an experimental cancer drug, tipifarnib, in a strain of mice genetically engineered to develop cardiovascular damage similar to that seen in progeria patients. Tipifarnib belongs to a class of drugs known as farnesyltransferase inhibitors (FTIs), which are being tested in people with myeloid leukemia, neurofibromatosis and other conditions. The team had previously found that FTI drugs could reverse structural abnormalities in skin cells taken from progeria patients and grown in the laboratory.

"This approach worked much better than we thought it would. Not only did this drug prevent these mi
'/>"/>

Contact: Geoff Spencer
spencerg@mail.nih.gov
301-402-0911
NIH/National Human Genome Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Vitamin C supplements may reduce benefit from wide range of anti-cancer drugs
2. Novel anti-cancer mechanism found in long-lived rodents
3. Gene therapy anti-cancer research featured in Scientific American
4. Drug reverses mental retardation caused by genetic disorder
5. Blood vessel protein reverses macular degeneration, diabetic retinopathy in mice
6. New discoveries from Harvard and Baylor get to the heart of cardiovascular disease
7. Gladstone and Izumi Bio in partnership in regenerative medicine and cardiovascular disease
8. New research shows no link between aromatase inhibitors and cardiovascular problems
9. Genetic variants of USF1 are associated with the increased risk for cardiovascular disease
10. Cell Therapy for Cardiovascular Diseases
11. Medical breakthrough for organ transplants and cardiovascular diseases by Flemish researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... are too stressed they are often grouchy, grumpy, nasty, ... (BMI) at EPFL have just highlighted a fundamental synaptic ... the loss of social skills and cognitive impairment. When ... molecule in the brain. This was revealed by a ... Carmen Sandi,s team went to look for answers in ...
(Date:9/18/2014)... the protective tentacles of host anemones, but new research ... kilometres across the open ocean. Although the process of ... is the first time that the high level exchange ... Dr Steve Simpson, Senior Lecturer in Marine Biology and ... from the Australian Research Council Centre of Excellence for ...
(Date:9/17/2014)... doctoral student have designed a device based on a ... and dew., The device could provide water in drought-stricken ... Cheng Luo, professor in the Mechanical & Aerospace Engineering ... College of Engineering department, published "Bioinspired Plate-Based Fog Collectors" ... Society) Applied Materials & Interfaces ...
Breaking Biology News(10 mins):How stress tears us apart 2Expedition finds Nemo can travel great distances to connect populations 2Expedition finds Nemo can travel great distances to connect populations 3Shorebird's beak inspires UT Arlington research on water collection 2
... MIAMI March 10, 2011 -- Scientists from the University ... were part of a national research team to find two ... Horizon oil spill. In a study published in this week,s ... offers new insight into the mechanism by which the crude ...
... of California, San Francisco (UCSF) has developed a new ... but untreatable and incurable neurodegenerative disease. The disease, frontotemporal ... dementia before age 65, after Alzheimer,s disease. Based ... work explains in part why the brain deteriorates in ...
... New Orleans, LA LSU oncologist Vince D. ... article reporting two chemotherapy drugs now indicated for second ... cancer are remarkably effective in treating a certain subset ... of Medicine at LSU Health Sciences Center New Orleans ...
Cached Biology News:New study reveals aerosol plumes downwind of the Deepwater Horizon oil spill 2UCSF report describes new model for neurodegeneration 2UCSF report describes new model for neurodegeneration 3Study shows new treatment strategy effective for certain lung cancers 2
(Date:9/18/2014)... Research and Markets has ... Industry Report 2014" report to their offering. ... 2014 is a professional and in-depth study on ... The report provides a basic overview ... industry chain structure. The N-acetylcysteine market analysis is ...
(Date:9/18/2014)... , Sept. 18, 2014  U.S. biotech company ... signing an exclusive license for technology developed by the ... gene expression in plants, including for applications in production ... The technology was developed under the direction ... at Kultevat and former president of the Danforth Plant ...
(Date:9/18/2014)... , Pennsylvanie, 18 septembre 2014 /PRNewswire/ ... en 1974, a été depuis ... compléter les évaluations cliniques traditionnelles par des ... Outcomes) et sur les impacts économiques des ... A cours d,une ...
(Date:9/18/2014)... rare diseases that afflict skeletal growth through abnormalities ... the fetal stage and is caused by genetic ... growth factor receptor 3 (FGFR3) has been associated ... (TD), a skeletal dysplasia that cause serious respiratory ... achondroplasia (ACH), which causes stunted growth and other ...
Breaking Biology Technology:Global N-acetylcysteine Industry Report 2014 2Kultevat obtains license of gene switch technology 21974 - 2014 - Mapi fĂȘte ses 40 ans 2Researchers use iPS cells to show statin effects on diseased bone 2Researchers use iPS cells to show statin effects on diseased bone 3
... Directors,of Eli Lilly and Company (NYSE: LLY ) ... December 1, 2008. Oberhelman, 55, currently serves as,a group ... Caterpillar,s,executive office. As a member of Lilly,s board, Oberhelman ... committee. He will stand for,election by Lilly shareholders at ...
... KANNAPOLIS, N.C., Oct. 20 Academia, science, industry,and ... at 10,AM at the Dedication and Open House ... the UNC Nutrition Research Building and the NC,State ... Nutrition,Research Building is home to NC A&T University, ...
... Recruitment, and Employment Branding joins Pierpoint International as Global VP of ... ... (PRWEB) October 20, 2008 -- Pierpoint International is pleased to announce ... and Diversity. Mr. Cantu, most recently served as AVP of Staffing ...
Cached Biology Technology:Douglas Oberhelman Elected to Lilly Board of Directors 2Douglas Oberhelman Elected to Lilly Board of Directors 3Campus Celebrates Historic Milestone 2Campus Celebrates Historic Milestone 3Campus Celebrates Historic Milestone 4Campus Celebrates Historic Milestone 5Robert Cantu Appointed Vice President of Pierpoint International 2
Peptide-affinity Purified Polyclonal Antibody to Olfactory Receptor, Family 2, Subfamily H, Member 3...
... collects data from balances and scales with RS232 ... other program. If you can type the weight ... collection process Simple to use parser extracts ... , Add user information , Collect data at ...
... collection and automation that is controlled from within ... , Pre-configured library of interfaces for balances, ... be added and configured by the user ... one spreadsheet , Allows for multi-tasking ...
...
Biology Products: