Navigation Links
Anti-angina drug shows protective effects from carbon monoxide
Date:8/6/2012

An international research team, led from the University of Leeds, has found that a common anti-angina drug could help protect the heart against carbon monoxide poisoning.

Animal studies have shown that the anti-angina drug ranolazine can significantly reduce the number of deaths from arrhythmias irregular or abnormally paced heartbeats that have been triggered by carbon monoxide.

The findings could have important implications for the development of a protective treatment for adults and children who have been exposed to toxic levels of the gas.

"When patients are admitted to hospital with carbon monoxide poisoning, the main problem doctors face is preventing damage to the body whilst the body slowly removes the chemical," said University of Leeds' Professor Chris Peers, who led the research. "We've shown that ranolazine can rapidly protect the heart and prevent the kind of cardiac events which threaten patients long after their exposure to the gas."

Carbon monoxide poisoning causes 1.6 million deaths worldwide every year. Many people who have been exposed to the gas develop cardiac arrhythmias, which if left untreated can lead to a fatal cardiac arrest.

Until now, however, the underlying biochemical mechanisms causing damage to the heart have not been fully understood, preventing the development of effective treatments.

Ranolazine, which is sold under the trade name Ranexa, was approved in 2006 in the US for the treatment of angina. The drug works by targeting a sodium channel in the heart - the same channel that can also induce irregular heartbeats.

Researchers at the University of Leeds examined the effect of ranolazine in single cardiac cells, to learn why carbon monoxide can trigger arrhythmias. They found that exposure to the gas caused a key membrane channel carrying sodium ions through the heart to stay open for longer. This in turn caused calcium to build up within cells, with the combined effect altering the heart's regular cycle.

Colleagues at the Universit Montpellier 1 and Universit de Avignon in France then trialled ranozaline on rats exposed to carbon monoxide, to test its protective effects. They found that the drug markedly reduced the chance of arrhythmia in the animals.

"Whilst the link between arrhythmias and carbon monoxide has been known for over 50 years, this is the first piece of research to explain the underlying process," said University of Leeds' Professor Derek Steele, who co-authored the research. "At the molecular level, we have shown that the mechanism underlying this adverse effect of carbon monoxide is a rise in the level of nitric oxide within cells, which in turn alters the function of the sodium channel."

The findings may also help those living in built-up areas or whose work involves daily exposure to lower levels of carbon monoxide, such as firefighters, the researchers believe. A recent and extensive epidemiological study of nine million people in the US1 showed a clear link between environmental carbon monoxide exposure and hospitalisation due to cardiovascular complaints. As ranolazine is a daily medication for angina, the researchers suggest it may be suitable to protect patients from the harmful effects of chronic exposure, though human clinical trials will be required to confirm this.

"The next step will be to replicate these findings in human trials. As the drug has been clinically approved, roll out of this treatment could begin soon after we have these results," said Professor Peers.

Dr Hlne Wilson, Research Advisor at the British Heart Foundation (BHF), which co-funded the study, said:

"This study is a good example of research being used to better understand the underlying causes of an abnormal heart rhythm and in this case it has uncovered the ability of an old drug to perform a new trick. Carbon monoxide poisoning is tragically common but hopefully these promising results can be replicated in people so that it saves lives in the future."


'/>"/>

Contact: Richard Mellor
r.d.mellor@leeds.ac.uk
44-011-334-34031
University of Leeds
Source:Eurekalert

Related biology news :

1. New drug shows promise for kidney disease
2. Study shows how elephants produce their deep voices
3. Cut emissions further or face risks of high air pollution, study shows
4. To know a tiger is at least to start tolerating them, study shows
5. Alpine Fault study shows new evidence for regular magnitude 8 earthquakes
6. UC Berkeley survey shows college campuses can make good bird havens
7. Study shows economic feasibility for capturing carbon dioxide directly from the air
8. TREW Marketing Webcast Shows B2B Companies How to Reach Technical Audiences
9. Deadly liver cancer may be triggered by cells changing identity, UCSF study shows
10. Cancer Cell article shows first evidence for targeting of Pol I as new approach to cancer therapy
11. Seabirds study shows plastic pollution reaching surprising levels off coast of Pacific Northwest
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/13/2017)... 2017 Sandata Technologies, LLC, a leading ... industry, including Electronic Visit Verification™ (EVV™), announced today ... as Senior Vice President of Product Management. ... homecare experience to Sandata, where he will be ... align Sandata,s suite of solutions with the needs ...
(Date:1/12/2017)... , Jan. 12, 2017  Trovagene, Inc. (NASDAQ: ... DNA (ctDNA) technologies, today announced that it has signed ... and the Middle East ...  This milestone marks the first wave of international distribution ... urine and blood samples. The initial partners ...
(Date:1/12/2017)... YORK , Jan. 12, 2017  New research undertaken ... the office of the future.  1,000 participants were simply asked ... three months which we may consider standard issue.  Insights on ... of 2017 were also gathered from futurists and industry leaders ... Dr. James Canton .  Some of ...
Breaking Biology News(10 mins):
(Date:1/16/2017)... ... January 16, 2017 , ... Attagene , a Research ... U.S. Small Business Administration. The Tibbetts Award honors the Small Business Innovation ... and are considered the best of the best from the thousands of firms ...
(Date:1/13/2017)... Research and Markets has announced the addition ... Forecast to 2021" report to their offering. ... The biosimilars market is expected ... in 2016, at a CAGR of 26.3%. The ... type, and application. Factors such as rising incidence of various diseases, ...
(Date:1/13/2017)... ... January 13, 2017 , ... FireflySci, in response to ... three new solutions for measurements where traditional cuvette applications are not convenient. For ... an oddly-shaped sample that would not fit into a typical cuvette inside a ...
(Date:1/12/2017)... NE (PRWEB) , ... January 12, 2017 , ... ... hiring of Stephen Beck, who will work in the company’s Lincoln office as a ... chemical processes to design control systems for customers in the life science manufacturing and ...
Breaking Biology Technology: