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Anti-aging hormone Klotho inhibits renal fibrosis, cancer growth
Date:4/13/2011

that can cause tissue fibrosis or cancer metastasis.

The researchers reported for the first time that Klotho binds to the cells' transforming growth factor receptor and inhibits signaling required for epithelial-to-mesenchymal transition (EMT), a "master switch" that causes cells to morph into a more pliable form. EMT cancer cells can squeeze into surrounding tissue and eventually into the bloodstream, leading to metastatic spreading of cancer.

"This is further evidence that Klotho is an understudied tumor-suppressor and really quite important because it's secreted and flows through the body," said Dr. David Boothman, professor of radiation oncology and pharmacology, associate director for translational research and an author of the study. "It could be a major surveillance mechanism for blocking tumor formation and progression."


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Contact: Robin Russell
robin.russell@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Page: 1 2

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