Navigation Links
Anti-aging hormone Klotho inhibits renal fibrosis, cancer growth
Date:4/13/2011

that can cause tissue fibrosis or cancer metastasis.

The researchers reported for the first time that Klotho binds to the cells' transforming growth factor receptor and inhibits signaling required for epithelial-to-mesenchymal transition (EMT), a "master switch" that causes cells to morph into a more pliable form. EMT cancer cells can squeeze into surrounding tissue and eventually into the bloodstream, leading to metastatic spreading of cancer.

"This is further evidence that Klotho is an understudied tumor-suppressor and really quite important because it's secreted and flows through the body," said Dr. David Boothman, professor of radiation oncology and pharmacology, associate director for translational research and an author of the study. "It could be a major surveillance mechanism for blocking tumor formation and progression."


'/>"/>

Contact: Robin Russell
robin.russell@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Anti-aging gene linked to high blood pressure
2. Birth control has long-term effect on hormone exposure
3. Apelin hormone injections powerfully lower blood sugar
4. Children distressed by family fighting have higher stress hormones
5. Food can affect a cell in the same way hormones do
6. Hormone therapy associated with reduced colorectal cancer risk
7. Protein that regulates hormones critical to womens health found in pituitary
8. Pregnancy hormone predicts postpartum depression
9. Hormone-mimics in plastic water bottles -- just the tip of the iceberg?
10. Fatty foods -- not empty stomach -- fire up hunger hormone
11. Lack of happiness hormone serotonin in the brain causes impaired maternal behavior in mice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/5/2014)... PROVO, Utah , Dec. 4, 2014  Tute ... has raised $2.3 million in Series A1 funding led ... angel investors also participated in the investment round. ... as the healthcare community adopts next-generation sequencing and seeks ... disease," said Reid Robison , MD MBA, and ...
(Date:12/3/2014)...   Marvin Test Solutions , a trusted ... military, aerospace, and manufacturing organizations, today announced the ... TS-900 PXI semiconductor test platform . The TS-960 ... to customers at a fraction of the footprint ... "Our semiconductor customers asked for ...
(Date:11/21/2014)... According to a new market research report ... Control, Intrusion Detection, Parking Management, Under Vehicle Inspection), End ... - Global Forecasts to 2020", published by MarketsandMarkets, The ... $25 Billion in 2014 and is expected to reach ... 8.69%. Browse 116 market data Tables and ...
Breaking Biology News(10 mins):Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 3Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 2Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 3Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3
... from the AP-HP (Henri Mondor Hospital and Avicenne Hospital) ... evaluation of chronic illnesses" and CIC 202, at Tours) ... in the fight against lice. Faced with the emergence ... this new medication represents a real therapeutic alternative which ...
... school and college students who understand the geological age of ... understand and accept human evolution, according to a University of ... Evolution . The finding could give educators a ... typically covered in physical rather than biological science classes. ...
... increases and climate change could swiftly exacerbate drought in ... could lead to mass displacements of people, water and ... impacts. To compare drought impact and mitigation at ... hosting a three-day meeting this month that will bring ...
Cached Biology News:An end to lice: The effectiveness of a new oral treatment has been demonstrated 2Students' perceptions of Earth's age influence acceptance of human evolution, says U of Minn. study 2UC Riverside to host 3-day international meeting on drought 2
(Date:12/24/2014)... AUSTIN, Texas , Dec. 24, 2014 /PRNewswire/ ... company focused on gynecologic disease, announced today that ... with investors including Oracle Investment Management, Jack ... Vermillion directors. Total proceeds were $10.5 million, before ... working capital and general corporate purposes. ...
(Date:12/24/2014)... 23, 2014 SoundConnect’s ... designed to introduce cutting edge communication technology, ... partners of platform upgrades. This webinar series ... users in their quest to leverage web ... According to SoundConnect’s Marketing Manager, Seanna Baumgartner, ...
(Date:12/24/2014)... The report expects global cell isolation ... It also provides a carefully analyzed data about the ... the market. , Full Copy of Report @ ... market for cell expansion will keep witnessing growth at ... growth to be driven by rapid technological advancements, government ...
(Date:12/24/2014)... Dec. 23, 2014 Sigma-Aldrich Corporation (NASDAQ: ... waiting period under the Hart-Scott-Rodino Antitrust Improvements Act ... on December 22, 2014, thereby completing the U.S. ... the acquisition of the Company by Merck KGaA, ... satisfies another condition to closing the transaction, which ...
Breaking Biology Technology:Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 2The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 3Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 2Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 3
... Part of Genetic Testing Process Says ... American College of Medical Genetics, BETHESDA, ... before, ranging from home DNA test kits, tests that can,help ... tests. Along with greater availability of genetic tests and,increased Direct-to-Consumer ...
... Yves Lionel Assant is,the new Chairman of Gerresheimer,s ... was already a member of the Supervisory Board. ... position for personal reasons. He,remains a member of ... & life science supply and services,company with market ...
... international team including scientists from the London Centre for ... of the National Academy of Sciences (PNAS) demonstrating the ... The importance of the work lies in establishing how ... produced at particle accelerators and nuclear reactors can ...
Cached Biology Technology:Statement on Direct-To-Consumer Genetic Testing 2Statement on Direct-To-Consumer Genetic Testing 3Imaging quantum entanglement 2