Navigation Links
Anti-aging hormone Klotho inhibits renal fibrosis, cancer growth
Date:4/13/2011

DALLAS April 14, 2011 A natural hormone known to inhibit aging can also protect kidneys against renal fibrosis, UT Southwestern Medical Center researchers have demonstrated.

Scientists led by Dr. Makoto Kuro-o, associate professor of pathology, showed in mice that the anti-aging hormone Klotho suppressed both renal fibrosis a common complication of chronic kidney disease and the spread of cancer. The findings are available online in the Journal of Biological Chemistry.

More than 26 million people in the U.S. are affected by chronic kidney disease. Researchers say Klotho also helps patients with acute injury of the kidney that obstructs urine outflow or causes a drop in blood flow to the kidney. Nearly half of the patients in hospital intensive care units have some form of kidney injury due to drugs, surgery, bleeding or dehydration, said Dr. Kuro-o, the study's senior author who discovered Klotho more than a decade ago.

"Within a few days after injury, renal function can be completely gone," he said. "We show that Klotho injection in a drip infusion could be effective not only as an initial treatment for acute kidney injury, but also to prevent its progression into chronic kidney disease. This offers real hope for patients with renal disease."

The UT Southwestern researchers focused on mesenchymal cells: multipotent cells that can differentiate into a variety of cell types. These are essential for development and growth, but when the cells are out of balance, they can morph into a pathological form that causes fibrosis (toughening of the tissue layers) and metastasis in cancer cells, said Dr. Kuro-o.

Scientists involved in this study also found that Klotho prevents cancer migration and metastasis. In the study, they blocked a ureter to cause renal fibrosis or introduced human cancer cells in laboratory mice. Secreted Klotho was effective in blocking three signaling pathways TGF-1, Wnt and IGF-1
'/>"/>

Contact: Robin Russell
robin.russell@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Anti-aging gene linked to high blood pressure
2. Birth control has long-term effect on hormone exposure
3. Apelin hormone injections powerfully lower blood sugar
4. Children distressed by family fighting have higher stress hormones
5. Food can affect a cell in the same way hormones do
6. Hormone therapy associated with reduced colorectal cancer risk
7. Protein that regulates hormones critical to womens health found in pituitary
8. Pregnancy hormone predicts postpartum depression
9. Hormone-mimics in plastic water bottles -- just the tip of the iceberg?
10. Fatty foods -- not empty stomach -- fire up hunger hormone
11. Lack of happiness hormone serotonin in the brain causes impaired maternal behavior in mice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/27/2014)... strike that wiped them out if it had taken ... , A fresh study using up-to-date fossil records and ... new narrative of the prehistoric creatures, demise, some 66 ... few million years before a 10km-wide asteroid struck what ... included extensive volcanic activity, changing sea levels and varying ...
(Date:7/27/2014)... have discovered a new species of mayfly in the southern ... India. In fact, this is the first time that any ... collected in peninsular India. , The new species, called ... Soldan for his substantial contribution to the understanding of the ... of a study that describes the new mayfly in the ...
(Date:7/27/2014)... have shown the potential for global climate change to ... most part, ignored the interactions between increasing temperature and ... to damage crops. , A new study involving researchers ... significant, suggesting that policymakers need to take both warming ... , The study looked in detail at global production ...
Breaking Biology News(10 mins):Dinosaurs fell victim to perfect storm of events, study shows 2Study: Climate change and air pollution will combine to curb food supplies 2Study: Climate change and air pollution will combine to curb food supplies 3
... ORLEANSAlzheimer,s disease (AD) is a tragic disease that robs an individual ... the age of 65 now suffer from the disease and one ... to popular belief, Alzheimer,s does not only affect the elderly. Familial ... young as 30. The Study , Alzheimer,s ...
... for adults, teens, and youngsters. It is less clear ... growth during gestation. Now that scientists have determined that, ... a fetus, studies are underway to examine the mother/fetus/exercise/health ... Entitled The Effects of Maternal Exercise on Fetal Breathing ...
... of people around the world, causing numerous problems ranging ... issues. Initial drug use can be motivated by curiosity ... rats, it can also be the result of a ... new study examines the impact of social isolation on ...
Cached Biology News:Computational model examines the pathways of Alzheimer's that strikes at the young 2Effects of maternal exercise on fetal breathing movements 2Early isolation linked to enhanced response to cocaine 2
(Date:7/28/2014)... , July 28, 2014  InterMune, Inc. (NASDAQ: ... its second quarter 2014 financial results at the close ... live conference call and webcast will be hosted by ... Interested investors and others may participate in ... 212-231-2900 (international), conference ID#21728775. A replay of the webcast and ...
(Date:7/28/2014)... Muncie, IN (PRWEB) July 28, 2014 ... Aeromodeling Center, in Muncie IN, is pleased to announce ... by the National Museum of the United States Air ... than a year-long process that concluded this spring with ... for the Dayton, OH museum. , The National ...
(Date:7/25/2014)... Calif. , July 25, 2014 Amgen ... of Directors today declared a $0.61 per share dividend ... be paid on Sept. 5, 2014, to all stockholders ... Aug. 14, 2014.  About Amgen Amgen ... patients suffering from serious illnesses by discovering, developing, manufacturing ...
(Date:7/25/2014)... 2014 Research and Markets  has ... Market 2014-2018" report to their offering. ... Metabolomics or Metabonomics is the scientific study of ... new experimental technique that is being widely used ... are small molecules that are present in blood, ...
Breaking Biology Technology:InterMune to Release Second Quarter Financial Results on August 6 2AMA’s National Model Aviation Museum Granted Full Civilian Museum Certification by the National Museum of the United States Air Force 2Amgen Announces 2014 Third Quarter Dividend 2Amgen Announces 2014 Third Quarter Dividend 3Global Metabolomics Market 2014-2018: Key Vendors are Agilent, Bio-Rad, Bruker, Human Metabolome and Metabolon 2
... College (CVTC) will receive a $500,000 grant from ... nanotechnology incubator on their Gateway Manufacturing Technology Center in ... systems at the scale of the atom. , ,"Through ... nanotechnology industry can grow, expand, and reach its full ...
... Wis. Small Tree Communications , a ... announced its 10Gb Ethernet solution for Apples Xserve G5. ... Mac OS X Server 10.4 Tiger, the company claims ... ,In addition to proprietary networking drivers, Small Trees solution ...
... Medical imaging software developer Cedara Software and ... for Kodak to offer Cedara B-CAD to its customers ... CARESTREAM Mammography Workstation. , ,Cedara B-CAD is a Computer ... of breast lesions using ultrasound images, providing tools for ...
Cached Biology Technology:
Human BMP 2 Construction Kit provides antigen affinity purified polyclonal capture and tracer antibodies, and antigen standard for development of approximately ten microplate assays....
...
... pAcGHLT-A,B,C Baculovirus ... Set,pAcGHLT-XylE Baculovirus ... Powder,Thrombin Dilution ... Cocktail,Insect Cell ...
...
Biology Products: