Navigation Links
Anti-aging gene linked to high blood pressure
Date:8/19/2009

OKLAHOMA CITY Researchers at the University of Oklahoma Health Sciences Center have shown the first link between a newly discovered anti-aging gene and high blood pressure. The results, which appear this month in the journal Hypertension, offer new clues on how we age and how we might live longer.

Persistent hypertension, or high blood pressure, is a risk factor for stroke, heart attack, heart failure, arterial aneurysm and is the leading cause of chronic kidney failure. Even a modest elevation of arterial blood pressure leads to shortened life expectancy.

Researchers, led by principal investigator Zhongjie Sun, tested the effect of an anti-aging gene called klotho on reducing hypertension. They found that by increasing the expression of the gene in laboratory models, they not only stopped blood pressure from continuing to rise, but succeeded in lowering it. Perhaps most impressive was the complete reversal of kidney damage, which is associated with prolonged high blood pressure and often leads to kidney failure.

"One single injection of the klotho gene can reduce hypertension for at least 12 weeks and possibly longer. Klotho is also available as a protein and, conceivably, we could ingest it as a powder much like we do with protein drinks," said Sun, M.D., Ph.D., a cardiovascular expert at the OU College of Medicine.

Scientists have been working with the klotho gene and its link to aging since 1997 when it was discovered by Japanese scientists. This is the first study showing that a decline in klotho protein level may be involved in the progression of hypertension and kidney damage, Sun said. With age, the klotho level decreases while the prevalence of hypertension increases.

Researchers used one injection of the klotho gene in hypertensive research models and were able to markedly reduce blood pressure by the second week. It continued to decline steadily for the length of the project 12 weeks.
'/>"/>

Contact: Diane Clay
diane-clay@ouhsc.edu
405-271-2323
University of Oklahoma
Source:Eurekalert  

Page: 1 2

Related biology news :

1. A new idea for how anti-aging products delay ripening of fruit and wilting of flowers
2. Rodent size linked to human population and climate change
3. LSUHSC shows for first time infant inhalation of ultrafine air pollution linked to adult lung disease
4. Genetic marker linked to problem behaviors in adults with developmental disabilities
5. Early-life experience linked to chronic diseases later in life: UBC research
6. Further gene mutations linked to autism risk
7. Protein linked to change in tissue that surround and support breast tumors
8. Dioxins in food chain linked to breastfeeding ills
9. Scientists uncover mode of action of enzyme linked with several types of cancer
10. Protein linked to mental retardation controls synapse maturation, plasticity, CSHL team finds
11. UCSF discovers new glucose-regulating protein linked with diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Anti-aging gene linked to high blood pressure
(Date:9/18/2014)... A team of researchers from McGill University and ... form of polyethylene ,microbeads, Canadian Journal of ... likely originate from cosmetics, household cleansers, or industrial ... abrasives. Owing to their small size and buoyancy, ... Microplastics are a global contaminant in the ...
(Date:9/18/2014)... Americans to undertake jaunts into the countryside each year could ... a century, according to new research. , Climate change could ... States as summer temperatures linger later into the year, Princeton ... Biogeography . For instance, the paper birch a popular ... could change color one to three weeks later by ...
(Date:9/18/2014)... and their colleagues have built the first smartphone ... performance and behavioral trends. In other words, your ... if you don,t -- and how that affects ... happiness, stress, depression and loneliness to their academic ... population for example, to monitor mental health, ...
Breaking Biology News(10 mins):Microplastic pollution discovered in St. Lawrence River sediments 2Fall foliage season may be later, but longer on warmer Earth 2Fall foliage season may be later, but longer on warmer Earth 3Fall foliage season may be later, but longer on warmer Earth 4New Dartmouth smartphone app reveals users' mental health, performance, behavior 2New Dartmouth smartphone app reveals users' mental health, performance, behavior 3New Dartmouth smartphone app reveals users' mental health, performance, behavior 4
... Chapel Hill, NC In its early stages, ... and maintenance of male sex characteristics) for growth, and ... to slow cancer,s development and spread. ... androgen-blocking therapies are ineffective. Scientists aren,t sure how ...
... of local water increases the resistance of coral reefs to ... in Marine Ecology Progress Series . Florida Institute of ... Dan Wagner led the study, which provides concrete evidence for ... in a rapidly changing world. Van Woesik and ...
... tunable fluorescent nanoparticles known as quantum dots make ideal ... tissue biopsies, Emory and Georgia Tech scientists have demonstrated. ... of the July 15 issue of Analytical Chemistry ... can distinguish the Reed-Sternberg cells that are characteristic of ...
Cached Biology News:UNC team finds new target for treatment of advanced prostate cancer 2Multicolor quantum dots aid in cancer biopsy diagnosis 2
(Date:9/18/2014)... September 18, 2014 Leatherwood Plastics ... listed material, to stay competitive in the semiconductor, ... high-performance materials ultimately impact product quality and productivity, ... owner. , Established in 1980 in Lewisville, TX, ... many fabricators have left the business. Much of ...
(Date:9/18/2014)... 2014  MEI Pharma, Inc. (Nasdaq: MEIP ), ... therapies for cancer, announced today that Daniel P. Gold ... BioCentury,s NewsMakers in the Biotech Industry conference on ... the Millennium Broadway Hotel & Conference Center in ... can be accessed at www.meipharma.com . A replay will ...
(Date:9/18/2014)... , Sept. 18, 2014 /PRNewswire/ - Oncothyreon Inc. ... of previously announced concurrent but separate underwritten offerings of ... to the public of $2.00 per share, for expected ... its Series A Convertible Preferred Stock at a price ... gross proceeds of $20 million. Each share of Series ...
(Date:9/18/2014)... ST. LOUIS , Sept. 18, 2014 /PRNewswire/ ... ) announced today it has entered into a ... Michigan (U-M) Medical School,s Vector Core. Under the ... Sigma CRISPR technology, experimental design consultation, and dedicated ... poised to accelerate gene editing-based research at the ...
Breaking Biology Technology:Leatherwood Plastics Selects Vycom’s Flametec PVC-C Material to Stay Competitive in Semiconductor and Lab Equipment Industries 2MEI Pharma To Present At BioCentury's NewsMakers Conference 2MEI Pharma To Present At BioCentury's NewsMakers Conference 3Oncothyreon Prices $40 Million Concurrent Public Offerings of Common Stock and Preferred Stock 2Oncothyreon Prices $40 Million Concurrent Public Offerings of Common Stock and Preferred Stock 3Sigma-Aldrich, University of Michigan Medical School Establish CRISPR Core Lab Partnership 2Sigma-Aldrich, University of Michigan Medical School Establish CRISPR Core Lab Partnership 3Sigma-Aldrich, University of Michigan Medical School Establish CRISPR Core Lab Partnership 4
... SAN DIEGO and EDISON, N.J., Nov. 4, 2010 ... Corporation (Nasdaq: THOR ), announced today the ... LLC, the global private equity firm, in an all ... a recognized worldwide leader in hemostasis management and Point-of-Care ...
... relatively advanced tools after their brains evolved a greater capacity ... why it took early humans almost two million years to ... Researchers used computer modelling and tiny sensors embedded in gloves ... in order to make two types of tools during the ...
... Corporation (Nasdaq: MATK ) announced today that ... / Mid Cap Conference being held on November 16-17, ... Officer is scheduled to present on Tuesday, November 16 ...  A live audio webcast of the presentation can be ...
Cached Biology Technology:International Technidyne Corporation Acquired by Warburg Pincus 2International Technidyne Corporation Acquired by Warburg Pincus 3Stone Age humans needed more brain power to make big leap in tool design 2Martek to Present at Upcoming Citi Small / Mid Cap Conference 2
Goat polyclonal to Nebraska Calf Diarrhea Virus (FITC) ( Abpromise for all tested applications). Antigen: Bovine (Nebraska Calf Diarrhea Virus)....
DNA fragmentation factor & Inhibitor of CAD...
Rabbit polyclonal to Methionine Aminopeptidase 2 ( Abpromise for all tested applications). entrezGeneID: 10988 SwissProtID: P50579...
Phospho-FKHR (Thr24)/FKHRL1 (Thr32) Antibody...
Biology Products: