Navigation Links
Anthrax cellular entry point uncovered
Date:1/25/2008

BIRMINGHAM, Ala. The long-sought-after biological gateway that anthrax uses to enter healthy cells has been uncovered by microbiologists at the University of Alabama at Birmingham (UAB).

Anthrax spores enter the cell through something called Mac-1, a receptor that sits on the surface of certain cells.

This is the first study to uncover exactly how the bacteria get inside cells to begin with, the UAB researchers said. Previous studies have shown what happens after anthrax spores enter the body and wreak havoc.

Unraveling the anthrax-Mac-1 gateway is a milestone in the ongoing efforts to protect humans from bioterrorism and biological warfare, the UAB microbiologists said. Such a discovery will speed the development of new drugs and vaccines to fight or prevent anthrax infection, and advance the understanding of bacterial infection.

The findings are published in the online version of the journal Proceedings of the National Academy of Sciences and will soon appear in a print edition.

We know anthrax infection can occur in wild and domestic animals, but in humans this disease is extremely rare and very dangerous. It is a bioweapon, said John Kearney, Ph.D., a professor in the UAB Department of Microbiology and co-author on the study. This study reveals the biological paradigm that makes the anthrax spore clever enough to target the Mac-1 receptor, and use this entry point to boost its lethality.

Bacillus anthracis infection occurs in three forms: cutaneous (skin), inhalation and through swallowing spores. The skin infection is the most common type and can be treated with antibiotics if diagnosed rapidly.

The more serious form is inhalation anthrax, which was diagnosed in a few adults during the anthrax scare after the Sept. 11, 2001, terror attacks against the United States.

In the UAB study, researchers worked under strict bio-safe conditions to infect cultures of cells and la
'/>"/>

Contact: Troy Goodman
tdgoodman@uab.edu
205-934-8938
University of Alabama at Birmingham
Source:Eurekalert

Page: 1 2

Related biology news :

1. Using carbon nanotubes to seek and destroy anthrax toxin and other harmful proteins
2. Team IDs weakness in anthrax bacteria
3. Bioengineers at University of Pennsylvania devise nanoscale system to measure cellular forces
4. Boston College profs study oxidative stress subcellular to discover its role in diseases
5. Studying component parts of living cells with carbon nanotube cellular probes
6. Story ideas from Molecular & Cellular Proteomics
7. e-Science points to pollution solutions
8. Salmon garnish points the way to green electronics
9. NIH awards UC $9 million grant to improve patient point-of-care technologies
10. Research points towards early cancer detection
11. New thoracic imaging approach can pinpoint underlying venous problems
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/8/2015)... Florida , July 8, 2015 ... evolving as this summer,s must have products such as wearables, ... demand as popularity for biometrics based devices continues to rapidly ... NXT-ID, Inc. (NASDAQ: NXTD ), Google Inc. (NASDAQ: ... (NYSE: FIT ), GoPro, Inc. (NASDAQ: GPRO ) ...
(Date:7/7/2015)... , July 7, 2015  Based on ... Frost & Sullivan recognizes Credence ID, LLC with ... Entrepreneurial Company of the Year Award. Credence ID ... aid in its mission of offering enrollment and ... globally. As Credence ID was formed by experts ...
(Date:7/2/2015)... DUBLIN , June 25, 2015 ... has announced the addition of the "Natural ... Hybrid), Technologies (Recognition, IVR, OCR, Pattern & Image ... to their offering. The key vendors ... Google, HP, IBM Corporation, Microsoft Corporation, NetBase Solutions, ...
Breaking Biology News(10 mins):Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 2Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 3Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 4Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 5Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 6Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 2Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 3Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 4Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 5Natural Language Processing Market by Type (Rule-Based, Statistical, and Hybrid), Technologies (Recognition, IVR, OCR, Pattern & Image Recognition) - Worldwide Forecast to 2020 2
... round for the winter holidays, some faces may be ... that the amount of social interaction between extended family ... mother or father. Thomas Pollet and colleagues at ... how far maternal grandparents and paternal grandparents will go ...
... used to treat certain cancers and rheumatoid arthritis appears ... School of Medicine researchers report in the Journal of ... the antibody continue to be observed long after the ... The antibody, rituximab (anti-CD20), depletes B cells. Experimental ...
... For the first time in 40 years of space ... European launch site in Kourou. Jules Vernes, the first ... being prepared for launch. The 48 m3 pressurised ... developed in Europe has been inspected and closed, fulfilling ...
Cached Biology News:Family ties that bind: Maternal grandparents are more involved in the lives of their grandchildren 2Cancer and arthritis therapy may be promising treatment for diabetes 2Final preparations for first human-rated spacecraft to be lauched from Europe's Spaceport 2Final preparations for first human-rated spacecraft to be lauched from Europe's Spaceport 3
(Date:7/30/2015)... , July 30, 2015  Discovery Laboratories, ... it has received the second $1.0M tranche under ... Research (SBIR) grant valued at up to $3.0 ... aerosolized KL4 surfactant as a potential medical countermeasure ...  Discovery Labs was awarded an initial $1.0 million ...
(Date:7/29/2015)... July 30, 2015 According to a ... Growth, Trends & Forecasts (2015-2020), , published by Mordor Intelligence, ... billion by the end of 2020, with North ... more than 40% of the global market size. The Global ... CAGR of 13.7% during the period of (2015-2020). ...
(Date:7/29/2015)... 29, 2015  AsureQuality and Ubiquitome have agreed ... applications in food and primary production sectors. The ... PCR device, the Freedom4. AsureQuality provides ... the supermarket shelf for producers, processors and Competent ... animal disease control and pest management and surveillance ...
(Date:7/29/2015)... YORK , July 29, 2015  Therapath ... testing, announces increased partnerships with VA and Military ... Epidermal Nerve Fiber Density (ENFD) and Sweat Gland ... small fiber neuropathy ( https://therapath.com/skin ). ... Nerve Fiber Density (ENFD) on punch skin biopsy ...
Breaking Biology Technology:Discovery Labs Receives $1.0 million under an SBIR Grant in Continuing Support of the Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 2Discovery Labs Receives $1.0 million under an SBIR Grant in Continuing Support of the Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 3Asia Pacific to Dominate the Global Stem Cell Market - Vericel Corporation, Ocata Therpeutics, Athersys Inc., Cryo-Cell International, Geron Corporation, StemCells, Inc. Among the Major Players 2Asia Pacific to Dominate the Global Stem Cell Market - Vericel Corporation, Ocata Therpeutics, Athersys Inc., Cryo-Cell International, Geron Corporation, StemCells, Inc. Among the Major Players 3AsureQuality and Ubiquitome Partner on Applications for Mobile Molecular Food Safety Testing 2Neuropathology services for VA and Military health systems 2
... of African American Celebs Join Obama in Knowing their Roots in ... of African descent spawn trend in African Americans to trace roots ... ... DC (PRWEB) November 27, 2008 -- One thing President-Elect Barack Obama ...
... sailing a spacecraft by the optical force of the sun,s light. ... the oversized sails that have been tried. Now a team led ... Science has shown that the force of light indeed can ... to nano-proportions. , Their work opens the door to a ...
... must-have gift , ... New York, NY(PRWEB) November 26, 2008 --DNA 11, ... launch DNA Mini Portraits™, a more affordable line of DNA Art that ... most personal and unique gifting solution for this holiday season that are ...
Cached Biology Technology:Growing Interest in DNA-Based Genetic Testing Among African American with Historic Election of President Elect Barack Obama 2Growing Interest in DNA-Based Genetic Testing Among African American with Historic Election of President Elect Barack Obama 3'The photon force is with us': Harnessing light to drive nanomachines 2DNA 11, Creators of DNA Art, Introduces a More Affordable Line of Custom Portraits for this Year's Gift Giving Season 2