Navigation Links
Ant guts could pave the way for better drugs
Date:3/25/2008

Scientists have discovered two key proteins that guide one of the two groups of pathogenic bacteria to make their hardy outer shells -- their defense against the world.

The work, they said, could allow researchers to create new antibiotics against gram-negative bacteria, like E. coli and salmonella, that would destroy these bacteria by disabling the mechanism that produces their protective coating.

"A long-term goal is to find inhibitors of these proteins we have discovered," said Natividad Ruiz, a research molecular biologist at Princeton University and the lead author on the paper describing the work. "Small molecule inhibitors could become antibiotics that subvert the outer membrane."

The research, conducted by Ruiz, Thomas Silhavy, Princeton's Warner-Lambert Parke-Davis Professor of Molecular Biology, and others from Harvard University, is described in the online edition of the April 8 Proceedings of the National Academy of Sciences.

The team discovered the proteins through an extended process of elimination. The scientists looked at microbes in the guts of carpenter ants. The bacteria, which have lived there for millions of years -- passed on over many generations -- have lost many of the traits necessary for survival in the outer world. As a result, their collection of genes, known as a genome, is far smaller and simpler than the genome of E. coli.

Scientists sequenced the genome of the model bacterium E. coli 11 years ago, yet they still do not understand the functions of about 40 percent of the thousands of proteins produced by those genes, according to Ruiz. Proteins are the workhorses of cells, directing and producing the creation of many key cell structures and functions.

In contrast, the genome of the bacteria found in the ant gut, Blochmannia floridanus, contains the instructions for only 583 proteins. Since the bacteria are closely related, nearly all of Blochmannia's genes -- 564 -- are foun
'/>"/>

Contact: Kitta MacPherson
kittamac@princeton.edu
609-258-5729
Princeton University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Newly created cancer stem cells could aid breast cancer research
2. Obesity and lack of exercise could enhance the risk of pancreatic cancer
3. Finding that 1-in-a-billion that could lead to disease
4. 60 second test could help early diagnosis of common brain diseases
5. Auto immune response creates barrier to fertility; could be a step in speciation
6. Paracetamol, one of most used analgesics, could slow down bone growth
7. Drug could improve pregnancy outcomes in wider range of women with insulin resistance
8. Thousands of starving children could be restored to health with peanut butter program
9. Nanotech could make solar energy as easy and cheap as growing grass
10. CO2 emissions could violate EPA ocean-quality standards within decades
11. MIT model could improve some drugs effectiveness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2015)... 2015 NXT-ID, Inc. (NASDAQ: NXTD ) ... on the growing mobile commerce market, announces that its ... New York Design Awards under the category  ,Product Design ... Design Awards are part of a global multi-disciplinary awards ... from the marketplace, industry and judging panel. Winners will ...
(Date:4/8/2015)... 2015  Infinisource, a leading provider of SaaS-based Human ... a leading supplier of biometric identification and security ... most advanced biometrically-enabled time clock, the companies announced ... is setting a bold, new standard for the ... small and mid-size employer. When connected to the ...
(Date:4/2/2015)... , April 2, 2015 Fingerprint ... fingerprint sensor FPC1025 from the distributor World Peace Industrial ... during Q2 2015 although the major part of the ... will be used by smartphone manufacturers in ... is included in the communicated revenue guidance of + ...
Breaking Biology News(10 mins):NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 110 Million 2
... Stents that keep weakened and flabby arteries from collapsing ... stents are no longer needed -- once the arteries ... choice but to leave them in place. Prof. ... Engineering has developed a new patent-pending fiber platform that ...
... fish food is a matter of debate. A high-profile study ... percent of their carbon from trees and leaves, evidence for ... But new research from the University of Washington shows ... much richer diet for fish and other aquatic life, according ...
... Applied mathematicians dissected the morphology of the plantain ... with a saddle-like arc midsection and closely packed ripples ... fan-like shapeelastic relaxation resulting from bending during differential growthwas ... ribbons. Haiyi Liang, a postdoctoral student at Harvard,s ...
Cached Biology News:A coating for life 2Fish food fight: Fish don't eat trees after all, says new study 2Fish food fight: Fish don't eat trees after all, says new study 3The cause behind the characteristic shape of a long leaf revealed 2
(Date:5/4/2015)... Achieved primarily through a proprietary paraffin and ... to 100x better detail than the industry standard. ... light microscopy methods, it needed another medium to measure ... frame of reference because it represents the highest standard ... the earliest discovery days of Ultralight Histology was to ...
(Date:5/4/2015)... --  Tocagen Inc. , a clinical-stage immuno-oncology company, ... investigational studies were presented at the 11 th ... Neurological Surgeons (AANS)/Congress of Neurological Surgeons (CNS) Section ... Washington, D.C. In addition, Tocagen ... and continues to advance towards initiation of a ...
(Date:5/1/2015)... BETHESDA, Md. , May 1, 2015  Northwest ... biotechnology company developing DCVax® personalized immune therapies for solid ... on the $28.5 million second tranche of a $40 ... ("Woodford"). Woodford first invested $25 million in ... 2015, Woodford entered into an agreement with the Company ...
(Date:5/1/2015)... - Softchoice, a leading North American IT solutions and managed services ... two Cisco® Partner Summit Country awards. Cisco ... Partner of the Year for Canada ... Montreal . "We are ... at this year,s conference," said David MacDonald , Softchoice,s ...
Breaking Biology Technology:Tocagen Presents Updated Interim Survival Data from Ongoing Clinical Studies at American Association of Neurological Surgeons (AANS)/Congress of Neurological Surgeons (CNS) Section on Tumors 2Tocagen Presents Updated Interim Survival Data from Ongoing Clinical Studies at American Association of Neurological Surgeons (AANS)/Congress of Neurological Surgeons (CNS) Section on Tumors 3Tocagen Presents Updated Interim Survival Data from Ongoing Clinical Studies at American Association of Neurological Surgeons (AANS)/Congress of Neurological Surgeons (CNS) Section on Tumors 4Tocagen Presents Updated Interim Survival Data from Ongoing Clinical Studies at American Association of Neurological Surgeons (AANS)/Congress of Neurological Surgeons (CNS) Section on Tumors 5NW Bio Closes On $28.5 Million Second Tranche Of Woodford $40 Million Financing 2NW Bio Closes On $28.5 Million Second Tranche Of Woodford $40 Million Financing 3Softchoice recognized with two Country Awards at Cisco Partner Summit 2015 2
... CLEVELAND, Ohio and LOD, Israel, November 26 ... simulation to advance,clinical performance, announces the world-wide release ... procedure. , ... over traditional open surgery, surgeons have been slow ...
... England, November 26 Sosei,Group Corporation ("Sosei"; TSE Mothers ... out-licensed its IP and Know How,relating to the RS(+) ... based pharma company, for the treatment and prophylaxis of,malaria. ... a highly efficacious anti-malarial drug that is approved in,its ...
... Calif., Nov. 25 Beckman Coulter, Inc. (NYSE: ... that simplify, automate, and innovate complex biomedical testing, announced today ... Business Development, will present at the following conferences: , ... , , , ...
Cached Biology Technology:New Colorectal Module From Simbionix Advances Laparoscopic Cancer Treatment 2Sosei Announces the Out-licensing of RS(+) Mefloquine to Treague Ltd for the Treatment and Prophylaxis of Malaria 2Beckman Coulter to Present at Upcoming Healthcare Conferences 2
sPLA2-XII Human, Rabbit Polyconal Antibody Anti-Human sPLA2-XII Antibody was raised in rabbits against Human sPLA2-XII His-Tagged Fusion Protein Antigen: The recombinant human protein sPLA-XII...
... computing power of your ValveBank system! Program ... PC computer running Windows 98, 2000, XP using ... to disk, print out program listings, then download ... simple step., EasyCode is used for programming before ...
Porcine Aortic Smooth Muscle Cells (PAOSMC) (>500,000 cells)...
Bovine Renal Artery Smooth Muscle Cells (BRASMC) (>500,000 cells)...
Biology Products: