Navigation Links
Another step toward resisting breast cancer
Date:9/21/2011

Medical researchers at the University of Leeds have come a step closer to understanding how to stop breast cancers from coming back.

Their findings, published in the International Journal of Cancer, suggest that some novel drugs that are being developed to tackle other cancers should be considered as a future treatment for breast cancer too.

Hormone therapies, such as tamoxifen, that target a protein responsible for tumour growth, have dramatically improved the treatment of breast cancer. Survival rates have improved considerably for patients whose breast cancer is spotted at an early stage and many patients with advanced disease can now have a much better quality of life.

But hormone therapies do not work in all patients and the tumours continue to grow and spread. In other patients, the hormone therapies work well at first but then their cancer often develops resistance and the tumour starts to grow again.

Leeds researchers have now pointed the finger at a key protein that they believe helps breast cancer to become resistant to hormone treatments. Laboratory studies on breast cancer tissue revealed that resistant tumours contained excessive levels of a protein known as FGFR3. Levels of this protein were much, much lower in tumours that had responded to hormone treatment. This suggests an important link between FGFR3 and resistance to hormone treatment.

"The options available for treating breast cancers that return are relatively limited at the moment. It is therefore of utmost importance to identify the factors that cause this resistance to help promote the development of novel drugs that can be used to target recurrent breast cancers," said Dr Darren Tomlinson, lead author of the research.

"Drugs are currently being made to target this protein FGFR3 - in other types of cancers. Our work suggests that these drugs could potentially be made available to treat some breast cancers too and help tackle this problem of resistance.

"Similar work has already been done on different proteins that belong to the same family. We've added to this research by identifying a further family member. If drugs could be developed to target these different family members, then in the future, patients could be given a personalised treatment programme, depending on how their particular cancer was trying to evade the hormone therapy," he said.

The work is very encouraging. We know that resistance to breast cancer is complex, so identifying the proteins involved brings us closer to understanding how to prevent breast cancer from coming back," said Dr Valerie Speirs, the study's principal investigator.


'/>"/>

Contact: Paula Gould
p.a.gould@leeds.ac.uk
44-113-343-8059
University of Leeds
Source:Eurekalert

Related biology news :

1. Not just another brick in the (plant cell) wall
2. Cells do talk to one another, but the question remains how
3. A nanoscale rope, and another step toward complex nanomaterials that assemble themselves
4. German-Russian Otto Schmidt Laboratory in St. Petersburg funded for another 3 years
5. Researchers find that one type of stem cell creates a niche for another type in bone marrow
6. In the neck of time: Scientists unravel another key evolutionary trait
7. Genome BC, Chile and Norway take another step closer to fully sequencing the salmon genome
8. Congress takes another stride toward public access to research
9. Chemicals that eased one environmental problem may worsen another
10. Babies and sleep: Another reason to love naps
11. Safeway gives another $317,000 for TGen breast cancer research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/24/2016)... Calif. , Nov. 23, 2016 Cercacor ... endurance athletes and their trainers non-invasively measure ... Index, Pulse Rate, and Respiration Rate in approximately 30 ... enables users easy and immediate access to key data ... part of a training regimen. Hemoglobin ...
(Date:11/22/2016)... Minn. , Nov. 22, 2016   MedNet ... supports the entire spectrum of clinical research, is pleased ... Medical LiveWire Healthcare and Life Sciences Awards ... award caps off an unprecedented year of recognition and ... trials for over 15 years. iMedNet ...
(Date:11/19/2016)... 18, 2016 Securus Technologies, a leading provider ... safety, investigation, corrections and monitoring, announced today that it ... to have an independent technology judge determine who has ... high tech/sophisticated telephone calling platform, and the best customer ... do most of what we do – which clearly ...
Breaking Biology News(10 mins):
(Date:12/6/2016)... Mount Laurel, NJ (PRWEB) , ... December 06, ... ... a white paper on December 1, 2016 asking the Federal Drug Administration (FDA) ... to the study of OA, OARSI is concerned about the growing population of ...
(Date:12/6/2016)... (PRWEB) , ... December 06, ... ... a Great Point Partners ("GPP") portfolio company, today announced it has acquired ... previously a subsidiary of Chiltern International and focuses on clinical trial drug ...
(Date:12/6/2016)... 2016  SRI International has been awarded a ... National Institutes of Health,s National Institute of Allergy ... (NIAID-DAIDS) to support the manufacturing and characterization of ... Under the seven-year contract, SRI will provide a ... candidate HIV-prevention products that emerge from investigator-initiated studies ...
(Date:12/5/2016)... , Dec. 5, 2016 Axovant Sciences Ltd. ... company focused on the treatment of dementia, today announced ... the treatment of Alzheimer,s disease will be presented at ... on Friday, December 9, 2016 in San ... results of both simple and complex measures of activities ...
Breaking Biology Technology: