Navigation Links
Another step toward resisting breast cancer
Date:9/21/2011

Medical researchers at the University of Leeds have come a step closer to understanding how to stop breast cancers from coming back.

Their findings, published in the International Journal of Cancer, suggest that some novel drugs that are being developed to tackle other cancers should be considered as a future treatment for breast cancer too.

Hormone therapies, such as tamoxifen, that target a protein responsible for tumour growth, have dramatically improved the treatment of breast cancer. Survival rates have improved considerably for patients whose breast cancer is spotted at an early stage and many patients with advanced disease can now have a much better quality of life.

But hormone therapies do not work in all patients and the tumours continue to grow and spread. In other patients, the hormone therapies work well at first but then their cancer often develops resistance and the tumour starts to grow again.

Leeds researchers have now pointed the finger at a key protein that they believe helps breast cancer to become resistant to hormone treatments. Laboratory studies on breast cancer tissue revealed that resistant tumours contained excessive levels of a protein known as FGFR3. Levels of this protein were much, much lower in tumours that had responded to hormone treatment. This suggests an important link between FGFR3 and resistance to hormone treatment.

"The options available for treating breast cancers that return are relatively limited at the moment. It is therefore of utmost importance to identify the factors that cause this resistance to help promote the development of novel drugs that can be used to target recurrent breast cancers," said Dr Darren Tomlinson, lead author of the research.

"Drugs are currently being made to target this protein FGFR3 - in other types of cancers. Our work suggests that these drugs could potentially be made available to treat some breast cancers too and help tackle this problem of resistance.

"Similar work has already been done on different proteins that belong to the same family. We've added to this research by identifying a further family member. If drugs could be developed to target these different family members, then in the future, patients could be given a personalised treatment programme, depending on how their particular cancer was trying to evade the hormone therapy," he said.

The work is very encouraging. We know that resistance to breast cancer is complex, so identifying the proteins involved brings us closer to understanding how to prevent breast cancer from coming back," said Dr Valerie Speirs, the study's principal investigator.


'/>"/>

Contact: Paula Gould
p.a.gould@leeds.ac.uk
44-113-343-8059
University of Leeds
Source:Eurekalert

Related biology news :

1. Not just another brick in the (plant cell) wall
2. Cells do talk to one another, but the question remains how
3. A nanoscale rope, and another step toward complex nanomaterials that assemble themselves
4. German-Russian Otto Schmidt Laboratory in St. Petersburg funded for another 3 years
5. Researchers find that one type of stem cell creates a niche for another type in bone marrow
6. In the neck of time: Scientists unravel another key evolutionary trait
7. Genome BC, Chile and Norway take another step closer to fully sequencing the salmon genome
8. Congress takes another stride toward public access to research
9. Chemicals that eased one environmental problem may worsen another
10. Babies and sleep: Another reason to love naps
11. Safeway gives another $317,000 for TGen breast cancer research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... -- The report "Video Surveillance Market by ... Devices), Software (Video Analytics, VMS), and Service (VSaaS, Installation ... 2022", published by MarketsandMarkets, the market was valued at ... reach USD 75.64 Billion by 2022, at a CAGR ... considered for the study is 2016 and the forecast ...
(Date:3/23/2017)... Research and Markets has announced the addition of the "Global ... 2025" report to their offering. ... The Global Vehicle Anti-Theft System Market is ... next decade to reach approximately $14.21 billion by 2025. ... all the given segments on global as well as regional levels ...
(Date:3/20/2017)... 20, 2017 PMD Healthcare announces the release ... Wellness Management System (WMS), a remote, real-time lung health ... PMD Healthcare is a Medical Device, Digital Health, and ... to creating innovative solutions that empower people to improve ... focus, PMD developed the first ever personal spirometer, Spiro ...
Breaking Biology News(10 mins):
(Date:4/26/2017)... ... April 26, 2017 , ... WonderWorks, Myrtle ... to showcase the future of deep space exploration and inspire space enthusiasts. The ... spacecraft and includes a guest appearance by former Shuttle Astronaut Don Thomas. , ...
(Date:4/26/2017)... Hong Kong (PRWEB) , ... April 26, 2017 ... ... be hosted in EMEA and North America this May ... from May 16-18 , Donald H. Taylor, Chairman of the Learning and Performance ...
(Date:4/25/2017)... ... 2017 , ... Franz Inc ., an early innovator ... market leader for Semantic Graph Database technology, today announced Allegro ... effective system for developing and deploying applications to solve the challenges developers face ...
(Date:4/25/2017)... ... April 25, 2017 , ... ... Metrology Partners.     , Covalent’s Analytical Services unit provides high-quality data to ... measured within 24 hours of receipt. There are no price premiums, and customers ...
Breaking Biology Technology: