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Another mechanism discovered by which sulforaphane prevents cancer
Date:2/28/2012

CORVALLIS, Ore. Researchers in the Linus Pauling Institute at Oregon State University have discovered yet another reason why the "sulforaphane" compound in broccoli and other cruciferous vegetables is so good for you it provides not just one, but two ways to prevent cancer through the complex mechanism of epigenetics.

Epigenetics, an increasing focus of research around the world, refers not just to our genetic code, but also to the way that diet, toxins and other forces can change which genes get activated, or "expressed." This can play a powerful role in everything from cancer to heart disease and other health issues.

Sulforaphane was identified years ago as one of the most critical compounds that provide much of the health benefits in cruciferous vegetables, and scientists also knew that a mechanism involved was histone deacetylases, or HDACs. This family of enzymes can interfere with the normal function of genes that suppress tumors.

HDAC inhibitors, such as sulforaphane, can help restore proper balance and prevent the development of cancer. This is one of the most promising areas of much cancer research. But the new OSU studies have found a second epigenetic mechanism, DNA methylation, which plays a similar role.

"It appears that DNA methylation and HDAC inhibition, both of which can be influenced by sulforaphane, work in concert with each other to maintain proper cell function," said Emily Ho, an associate professor in the Linus Pauling Institute and the OSU College of Public Health and Human Sciences. "They sort of work as partners and talk to each other."

This one-two punch, Ho said, is important to cell function and the control of cell division which, when disrupted, is a hallmark of cancer.

"Cancer is very complex and it's usually not just one thing that has gone wrong," Ho said. "It's increasingly clear that sulforaphane is a real multi-tasker. The more we find out about it, the more benefits it
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Contact: Emily Ho
Emily.ho@oregonstate.edu
541-737-9559
Oregon State University
Source:Eurekalert

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