Navigation Links
Another mechanism discovered by which sulforaphane prevents cancer
Date:2/28/2012

CORVALLIS, Ore. Researchers in the Linus Pauling Institute at Oregon State University have discovered yet another reason why the "sulforaphane" compound in broccoli and other cruciferous vegetables is so good for you it provides not just one, but two ways to prevent cancer through the complex mechanism of epigenetics.

Epigenetics, an increasing focus of research around the world, refers not just to our genetic code, but also to the way that diet, toxins and other forces can change which genes get activated, or "expressed." This can play a powerful role in everything from cancer to heart disease and other health issues.

Sulforaphane was identified years ago as one of the most critical compounds that provide much of the health benefits in cruciferous vegetables, and scientists also knew that a mechanism involved was histone deacetylases, or HDACs. This family of enzymes can interfere with the normal function of genes that suppress tumors.

HDAC inhibitors, such as sulforaphane, can help restore proper balance and prevent the development of cancer. This is one of the most promising areas of much cancer research. But the new OSU studies have found a second epigenetic mechanism, DNA methylation, which plays a similar role.

"It appears that DNA methylation and HDAC inhibition, both of which can be influenced by sulforaphane, work in concert with each other to maintain proper cell function," said Emily Ho, an associate professor in the Linus Pauling Institute and the OSU College of Public Health and Human Sciences. "They sort of work as partners and talk to each other."

This one-two punch, Ho said, is important to cell function and the control of cell division which, when disrupted, is a hallmark of cancer.

"Cancer is very complex and it's usually not just one thing that has gone wrong," Ho said. "It's increasingly clear that sulforaphane is a real multi-tasker. The more we find out about it, the more benefits it appears to have."

DNA methylation, Ho said, is a normal process of turning off genes, and it helps control what DNA material gets read as part of genetic communication within cells. In cancer that process gets mixed up. And of considerable interest to researchers is that these same disrupted processes appear to play a role in other neurodegenerative diseases, including cardiovascular disease, immune function, neurodegenerative disease and even aging.

The influence of sulforaphane on DNA methylation was explored by examining methylation of the gene cyclinD2.

This research, which was published in the journal Clinical Epigenetics, primarily studied the effect on prostate cancer cells. But the same processes are probably relevant to many other cancers as well, researchers said, including colon and breast cancer.

"With these processes, the key is balance," Ho said. "DNA methylation is a natural process, and when properly controlled is helpful. But when the balance gets mixed up it can cause havoc, and that's where some of these critical nutrients are involved. They help restore the balance."

Sulforaphane is particularly abundant in broccoli, but also found in other cruciferous vegetables such as cauliflower and kale. Both laboratory and clinical studies have shown that higher intake of cruciferous vegetables can aid in cancer prevention.


'/>"/>

Contact: Emily Ho
Emily.ho@oregonstate.edu
541-737-9559
Oregon State University
Source:Eurekalert

Related biology news :

1. Just another pretty face: Dartmouth professor investigates neural basis of prosopagnosia
2. New smart nanotherapeutics can deliver drugs directly to the pancreas
3. Another outbreak of coral disease hits the reefs of Kaneohe Bay, Oahu
4. Caterpillars mimic one another for survival
5. Another step toward resisting breast cancer
6. Not just another brick in the (plant cell) wall
7. Cells do talk to one another, but the question remains how
8. A nanoscale rope, and another step toward complex nanomaterials that assemble themselves
9. German-Russian Otto Schmidt Laboratory in St. Petersburg funded for another 3 years
10. Researchers find that one type of stem cell creates a niche for another type in bone marrow
11. In the neck of time: Scientists unravel another key evolutionary trait
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2017)... , May 5, 2017 RAM ... announced a new breakthrough in biometric authentication based ... quantum mechanical properties to perform biometric authentication. These new ... semiconductor material created by Ram Group and its ... entertainment, transportation, supply chains and security. Ram Group ...
(Date:4/17/2017)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... its 2016 Annual Report on Form 10-K on Thursday April 13, ... ... the Investor Relations section of the Company,s website at http://www.nxt-id.com ... http://www.sec.gov . 2016 Year Highlights: ...
(Date:4/11/2017)... Research and Markets has announced the addition of the ... ... grow at a CAGR of 30.37% during the period 2017-2021. ... prepared based on an in-depth market analysis with inputs from industry ... over the coming years. The report also includes a discussion of ...
Breaking Biology News(10 mins):
(Date:5/24/2017)... TX May 24, 2017 (PRWEB) , ... May ... ... Constant Connectivity , Medical systems are increasingly being developed with Wi-Fi connectivity to ... be easily moved from room to room. In addition, compact mobile devices including ...
(Date:5/23/2017)... Linda, Ca (PRWEB) , ... ... ... cells (PSCs) offer an unlimited source of human cardiovascular cells for research ... cardiac-directed differentiation methods makes it possible to generate large numbers of cardiomyocytes ...
(Date:5/23/2017)... ... 2017 , ... Vortex Biosciences , provider of circulating tumor cell (CTC) ... cells using Vortex microfluidic technology ” in Nature Precision Oncology on May 8th. ... Carlo and Dr. Matthew Rettig at the University of California, Los Angeles. The publication ...
(Date:5/23/2017)... ... ... Cambridge Semantics , the leading provider of Big Data management and analytics ... in Boston May 23-25 with a featured speaker and solution demos of its ... also a finalist for the Best of Show award. , James LaPointe, Managing Director ...
Breaking Biology Technology: