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Annals of Internal Medicine tip sheet for Jan. 19, 2010, issue
Date:1/18/2010

owever, most obese people who produce leptin normally are resistant to the weight-loss effects of the hormone. Leptin deficiency is a clinical syndrome associated with distinct conditions such as recent weight loss, diet- or exercise-induced hypothalamic amenorrhea, and lipoatrophy. Recombinant human leptin is an emerging potential therapy for these leptin-deficient conditions because in replacement doses, it normalizes energy homeostasis, neuroendocrine function, and metabolism. Replacement of leptin in physiologic doses may help people who have recently lost weight because relative leptin deficiency may drive them to eat more, expend less energy, and regain weight. Leptin also restores ovulatory menstruation in women with hypothalalmic amenorrhea and improves metabolic dysfunction in patients with lipoatrophy, including lipoatrophy associated with HIV or highly active antiretroviral therapy.


3. Atrial Fibrillation Risk Lower with Some Classes of Antihypertensives

Atrial fibrillation, or irregular heartbeat, is a major risk factor for thromboembolic events, particularly stroke. This risk is especially high in patients with high blood pressure. Antihypertensive drugs are known to reduce the risk for atrial fibrillation by lowering blood pressure. However, some classes of antihypertensives may have greater risk reduction through other mechanisms. Researchers studied 4,661 patients with atrial fibrillation against 18,642 matched control patients from a population of 682,993 patients treated for hypertension in the United Kingdom. They compared the risk for atrial fibrillation among hypertensive patients taking angiotensin-converting-enzyme (ACE) inhibitors, angiotensin II-receptor blockers (ARBs), or beta-blockers to the reference group taking calcium channel blockers. The researchers found that patients on long-term ACE-inhibitor, ARB, or beta blocker therapy had a reduced risk for atrial fibrillation compared to patients on calciu
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Contact: Angela Collom
acollom@acponline.org
215-351-2653
American College of Physicians
Source:Eurekalert

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