Navigation Links
Animal welfare scientists reveal infrequent and inconsistent acceptance of existing data by EPA to satisfy endocrine disruptor testing requirements
Date:11/1/2013

would consider OSRI submitted by test order recipients and third parties and determine whether it satisfied data requirements of the EDSP. OSRI is existing data that is either functionally equivalent to information obtained from the Tier 1 assays (i.e., data from assays that perform the same function as EDSP Tier 1 assays) or provides evidence of a potential effect on the endocrine system.

Most of the 52 chemicals in the first round of Tier 1 testing under the EDSP were pesticides for which there is a wealth of existing toxicity data. This data includes results of guideline animal tests conducted under 40 CFR Part 158 data requirements to support pesticide registration as well as research studies published in the peer-reviewed literature. Guideline studies generally include two-generation reproduction toxicity studies in rodents; 28-day, 90-day, and 1-year chronic exposure studies in rodents and dogs; and reproduction and life-cycle studies in fish and birds. With so many of these chemicals already being extensively tested, acceptance of OSRI is a primary means for avoiding duplicative data collection and minimizing further animal use.

The authors found that, due to a lack of clear guidance from the EPA, OSRI submissions by test order recipients were quite variable in their length and content. Some respondents requested waivers based on OSRI for all Tier 1 tests while others did not seek any waivers at all. Of the 412 waivers sought, the EPA granted only 93an overall OSRI acceptance rate of 23 percent. The 49 waivers for in vivo tests and 20 waivers for in vitro assays that use tissues collected from animals spared 3325 animals. However, at least 27,731 animals were estimated to have been used to perform the Tier 1 tests eventually required by the EPA after rejecting OSRI, with additional animals being used by laboratories in preparation for conducting the Tier 1 tests.

Despite language in the laws creating the EDSP that provides for the u
'/>"/>

Contact: Tasgola Bruner
TasgolaB@peta.org
770-518-1675
People for the Ethical Treatment of Animals
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Tagging aquatic animals can disrupt natural behavior
2. Aboriginal hunting practice increases animal populations
3. Why plants usually live longer then animals
4. Clean living is a luxury wild animals cant afford, study suggests
5. Coastal animals have their own tidal timer -- separate from the 24-hour body clock
6. Personality interactions between animals may dictate outcomes in the wild
7. Funding for animal testing alternative
8. Relating animals to humans could help conservation projects
9. LLNL scientists make new discoveries in the transmission of viruses between animals and humans
10. Cancer research implies future for personalized medicine, reduction in animal testing
11. Rubber slat mats could improve animal well-being
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/11/2014)... DUBLIN , Dec. 09, 2014 Research ... http://photos.prnewswire.com/prnh/20130307/600769 ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) ... Market in India 2015-2019" report to their ... in this market is the adoption of multimodal ... one characteristic of an individual for verification and ...
(Date:12/10/2014)... You,ve been here before: you desperately need to ... password, site key or the answer to your secret question. ... Today, Hoyos Labs , a digital ... finally put an end to the frustration that comes with ... 1U leverages a user,s smartphone to acquire his or her ...
(Date:12/10/2014)... 2014 CIE San Diego has launched an ... connective tissue that enhances care coordination among social service ... client-level information; earned a second $1 million grant from ... seniors aging in community and; will be recognized as ... th 4-6p. CIE San Diego today ...
Breaking Biology News(10 mins):Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 4
... bacterium or virus starts rummaging through the contents of a ... host,s DNA strands, it can alter the host,s biological course. ... particular sequences of DNA, to bend, kink and twist the ... any part of a DNA strand, but these seemingly random ...
... , HOUSTON -- (Aug. 30, 2012) -- The threads of ... biology are beginning to unravel, thanks to a new investigation ... Texas MD Anderson Cancer Center. In new research published ... Oleg Igoshin and MD Anderson,s Christian Ray offer a possible ...
... Bacteria in hyenas, scent glands may be the ... the current issue of Scientific Reports , show ... and the distinct microbial communities that reside in their ... and Michigan State University postdoctoral researcher. "A critical ...
Cached Biology News:Biophysicists unravel secrets of genetic switch 2Biophysicists unravel secrets of genetic switch 3Rice, MD Anderson scientists probe mystery of operon evolution 2Rice, MD Anderson scientists probe mystery of operon evolution 3Rice, MD Anderson scientists probe mystery of operon evolution 4Microbes help hyenas communicate via scent 2
(Date:12/22/2014)... , Dec. 22, 2014   Synthetic ... developer of pathogen-specific therapies for serious infections ... the microbiome, today announced positive topline safety ... clinical trial of SYN-004, the Company,s investigational ... Clostridium difficile (C. difficile) infection, ...
(Date:12/22/2014)... 22, 2014  Alternative Energy & Environmental Solutions, ... signed a letter of intent to acquire BioTechPharma ... patented a nanotechnology-based development platform used to create ... rapid on-site collection and testing to identify infectious ... in an immediate, non-invasive and cost-effective manner. ...
(Date:12/22/2014)... , Dec. 22, 2014  ( www.competitivehealth.com ) ... an online medical bill review and advocacy service, has ... the FREE WellCard Savings discount health services marketplace. ... that was more than they expected to pay. As ... health care costs, WellCard Savings is pleased to offer ...
(Date:12/22/2014)... 22, 2014 ITRA Global, one of ... of commercial real estate, has further expanded its global ... Perth and Brisbane, Western Australia, reports Mylinda Vick, CCIM, ... ITRA Global / ACORPP (Australian Corporate Property and ... company providing property services to a wide range of ...
Breaking Biology Technology:Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 2Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 3Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 4Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 5ALNE Announces Intention To Acquire BioTechPharma 2WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2ITRA Global Continues International Expansion in Perth and Brisbane, Australia 2
... Peripheral Neuropathic Pain in Non-Diabetic AdultsConference Call Scheduled ... MATEO, Calif., March 19 NeurogesX, Inc. (Nasdaq: ... on developing and commercializing novel pain management therapies, ... Committee for Medicinal Products for Human Use (CHMP) ...
... extensive experience in enterprise technology to rapidly expanding Chicago-based clinical ... as well as manage the company,s financial department. ... ... 2009 -- ClearTrial ( www.cleartrial.com ), a leading provider of ...
... to protect cotton plantationsINDIANAPOLIS and SAO PAULO, March ... subsidiary of The Dow Chemical Company (NYSE: ... received regulatory approval from the Brazilian National Technical ... Insect Protection technology in cotton in Brazil. ...
Cached Biology Technology:NeurogesX' Qutenza(TM) (NGX-4010) Receives Positive Committee Recommendation in European Union 2NeurogesX' Qutenza(TM) (NGX-4010) Receives Positive Committee Recommendation in European Union 3NeurogesX' Qutenza(TM) (NGX-4010) Receives Positive Committee Recommendation in European Union 4NeurogesX' Qutenza(TM) (NGX-4010) Receives Positive Committee Recommendation in European Union 5NeurogesX' Qutenza(TM) (NGX-4010) Receives Positive Committee Recommendation in European Union 6ClearTrial Names Software Industry Veteran Michael Bruns as Chief Operating Officer 2ClearTrial Names Software Industry Veteran Michael Bruns as Chief Operating Officer 3Dow AgroSciences Receives Approval for New Technology to Control Cotton Pests in Brazil 2
IKKbeta/IKK-2 Polyclonal Antibody 100 ug affinity purified rabbit polyclonal antibody. Reacts with human. Tested in Western blotting....
...
Request Info...
... The S.c. EasyComp Transformation Kit ... transformation-competent Saccharomyces cerevisiae cells. Advantages over ... spheroplast formation or LiCl methods include:- Cells ... than 30 minutes - Competent cell preparation ...
Biology Products: