Navigation Links
Animal study suggests that newborn period may be crucial time to prevent later diabetes
Date:11/2/2011

Pediatric researchers who tested newborn animals with an existing human drug used in adults with diabetes report that this drug, when given very early in life, prevents diabetes from developing in adult animals. If this finding can be repeated in humans, it may become a way to prevent at-risk infants from developing type 2 diabetes.

"We uncovered a novel mechanism to prevent the later development of diabetes in this animal study," said senior author Rebecca A. Simmons, M.D., a neonatologist at The Children's Hospital of Philadelphia. "This may indicate that there is an important developmental window, a period of time in which we can intervene to permanently protect the body's insulin-producing cells."

Simmons and lead author Sara E. Pinney, M.D., a pediatric endocrinologist at Children's Hospital, published the study in the October issue of Diabetologia.

The research may be relevant to children with intrauterine growth retardation (IUGR), a common complication during the mother's pregnancy. Simmons' previous research showed that IUGR, which is associated with decreased availability of nutrients and hormones to the developing fetus, permanently alters gene expression and impairs the function of insulin-producing cells in the pancreas. These defects have been shown to cause type 2 diabetes to develop in adulthood.

The study team used exendin-4 (Ex-4), a drug recently approved for use in adults with type 2 diabetesa condition in which a patient produces insufficient insulin, or is unable to process insulin normally. Although the drug's mechanism is not known, it has a hormone-like effect, raising insulin secretion in adults.

In their study, Simmons and Pinney used rats with an induced form of IUGR. They found that after being given to newborn rats, Ex-4 had epigenetic effectsmodifying gene function without changing the underlying DNA sequences. Ex-4 increased the expression of a gene called Pdx1 that is necessary for beta cells to function properly. Beta cells produce insulin in the pancreas of mammals, including humans.

"In our study, giving exendin-4 during the newborn period had permanent beneficial effects on beta cells," said Pinney. "This could be important for people, in whom abnormal changes in infancy may irreversibly alter beta cells and lead to adult-onset diabetes. If we can establish that treating at-risk human babies with exendin-4 or a similar compound has corresponding effects, we may have a new preventive approach for type 2 diabetes."

Simmons and Pinney cautioned that much follow-up research remains to be done, such as investigating more of the basic biology and evaluating the genome-wide effects of exendin-4, before their research findings could translate into clinical use in children.


'/>"/>

Contact: John Ascenzi
Ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
Source:Eurekalert

Related biology news :

1. Long-term study shows effect of climate change on animal diversity
2. Researchers find animal with ability to survive climate change
3. Researchers note differences between people and animals on calorie restriction
4. Earliest animal footprints ever found -- discovered in Nevada
5. Details of evolutionary transition from fish to land animals revealed
6. Drug-embedded microparticles bolster heart function in animal studies
7. Swamping bad cells with good in ALS animal models helps sustain breathing
8. Moderate use averts failure of type 2 diabetes drugs in animal model
9. Grapes may aid a bunch of heart risk factors, animal study finds
10. Animal and biological science highlights: San Antonio Fluid Dynamics Conference, Nov. 23-25
11. Discovery of giant roaming deep sea protist provides new perspective on animal evolution
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2016)... 31, 2016   ... the "Company") LegacyXChange is excited to release ... soon to be launched online site for trading 100% ... ) will also provide potential shareholders a sense of ... to an industry that is notorious for fraud. The ...
(Date:3/22/2016)... 22, 2016 According ... Market for Consumer Industry by Type (Image, Motion, ... (Communication & IT, Entertainment, Home Appliances, & ... to 2022", published by MarketsandMarkets, the market ... reach USD 26.76 Billion by 2022, at ...
(Date:3/17/2016)... 17, 2016 ABI Research, the leader ... global biometrics market will reach more than $30 ... from 2015. Consumer electronics, particularly smartphones, continue to ... anticipated to reach two billion shipments by 2021 ... Pavlakis , Research Analyst at ABI Research. "Surveillance ...
Breaking Biology News(10 mins):
(Date:4/29/2016)... 29, 2016 According to ... Research "Separation Systems for Commercial Biotechnology Market - ... Forecast 2015 - 2023", the separation systems for ... Mn in 2014 and is projected to expand ... 2023 to reach US$ 19,227.8 Mn in 2023. ...
(Date:4/29/2016)... ... April 29, 2016 , ... Intelligent Implant Systems announced today that ... 510(k) for sale in the United States. These components expand the capabilities of ... With one-level sales beginning in October of 2015, the company has seen significant sales ...
(Date:4/28/2016)... , April 28, 2016 ... company reports the Company,s CEO  was featured in ... Accelerators Enter When VCs Fear To Tread: ... Leader magazine is an essential business ... everything from emerging biotechs to Big Pharmas. Their ...
(Date:4/28/2016)... York, NY (PRWEB) , ... April 28, 2016 ... ... QuickSTAT has made significant investments in recruiting top industry experts, and expanding its ... Platform, which provides industry-leading tools for clients to manage their clinical trial projects. ...
Breaking Biology Technology: